Cytomegalovirus and Burkholderia cepacia complex prostatitis: Hickam's dictum in a post-renal transplant patient

Mendos, Angelina; Sundar, Shyam; Pai, Sanjay A

doi:10.1016/j.pathol.2016.08.013

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…CMV prostatitis has also been reported rarely in immunocompromised hosts, particularly among HIV‐positive patients, solid organ transplant recipients, and a patient with multiple myeloma receiving chemotherapy . Among transplant recipients, CMV prostatitis has been reported in 3 kidney, 1 liver, and 1 heart transplant recipient (Table ) . Most presented with mild obstructive symptoms and elevated prostate‐specific antigen several years after transplantation while undergoing concurrent treatment for allograft rejection.…”

Section: Discussionmentioning

confidence: 99%

Native kidney cytomegalovirus nephritis and cytomegalovirus prostatitis in a kidney transplant recipient

Cheng

Kao

Weber

et al. 2018

Transplant Infectious Dis

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We present a case of cytomegalovirus (CMV) native kidney nephritis and prostatitis in a CMV D+/R- kidney transplant recipient who had completed six months of CMV prophylaxis four weeks prior to the diagnosis of genitourinary CMV disease. The patient had a history of benign prostatic hypertrophy and urinary retention that required self-catheterization to relieve high post-voiding residual volumes. At 7 months post-transplant, he was found to have a urinary tract infection, moderate hydronephrosis of the transplanted kidney, and severe hydroureteronephrosis of the native left kidney and ureter, and underwent native left nephrectomy and transurethral resection of the prostate. Histopathologic examination of kidney and prostate tissue revealed CMV inclusions consistent with invasive CMV disease. This case highlights that CMV may extend beyond the kidney allograft to involve other parts of the genitourinary tract, including the native kidneys and prostate. Furthermore, we highlight the tissue-specific risk factors that preceded CMV tissue invasion. In addition to concurrent diagnoses, health care providers should have a low threshold for considering late-onset CMV disease in high-risk solid organ transplant recipients presenting with signs and symptoms of genitourinary tract pathology.

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Section: Discussionmentioning

confidence: 99%

Native kidney cytomegalovirus nephritis and cytomegalovirus prostatitis in a kidney transplant recipient

Cheng

Kao

Weber

et al. 2018

Transplant Infectious Dis

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“…38 In relation to all human rights abuses and impacts, people may face unique barriers to seeking remedy based on their real or perceived SOGIESC. 39…”

Section: Business Human Rights and Sogiescmentioning

confidence: 99%

Reclaiming the Human Rights Foundations of the UN Standards of Conduct for Business on Tackling Discrimination against LGBTI People

Lyons

Christiancy

2022

Bus. and hum. rights j.

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The business and human rights field and the international LGBTI human rights agenda have evolved almost entirely separately. The United Nations ‘Standards of Conduct for Business on Tackling Discrimination against LGBTI People’ (2017) is the primary effort to bridge this gap. Although drafted in a way that strongly aligns with the second pillar of the United Nations Guiding Principles on Business and Human Rights on corporate responsibility, the dissemination of the Standards has mainly been untethered from the human rights framework and system. This article identifies the need to reassert the human rights foundations of the Standards and leverage their existing momentum to set out a more robust research and policy agenda for meaningfully accounting for sexual orientation, gender identity and expression, and sex characteristics in business and human rights frameworks. To that end, the article sets out priority areas for greater attention from researchers, decision-makers and advocates.

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“…Anterior ( A and C ) and left lateral ( B and D ) MIP 18 F-FDG PET images, fused 18 F-FDG PET/CT axial ( E – J ) images, and baseline ( A and B , E – G ) showed metabolically active lesions noted in the right renal bed at the level of L1 vertebra (2 foci; SUV max , 8.2; white bold thick arrow), posterior aspect of the right abdominal wall muscles (SUV max , 4.5; white thin arrow, also soft tissue thickening on CT), multifocal uptake predominantly in the superior half and inferior pole (SUV max , 11.9; white dotted arrow) of the transplant kidney in the right iliac fossa, subcentimeter precaval node (SUV max , 6.2), soft tissue lesion in the bulky right prostate (SUV max , 10.10; black thin arrow), and lesion abutting the lesser curvature of the stomach (SUV max , 13.14); follow-up 18 F-FDG PET/CT performed at seventh week, which revealed no new infective site, showed residual focus in the transplant kidney (smaller areas in the superior half and a small focus in the inferior pole; SUV max , 4.6, white dotted arrow). The rest of the lesions showed complete metabolic resolution 1–5 …”

mentioning

confidence: 97%

Multifocal Burkholderia cepacia Infection in Postrenal Transplantation Fever

Sonavane,

Jamale,

Bose

et al. 2024

Clin Nucl Med

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Nosocomial Burkholderia cepacia infection in the clinical setting of postrenal transplantation pyrexia of unknown origin and the role of 18F-FDG PET/CT in treatment optimization in such situation is presented in this report. The consequence of fastidious infection by nosocomial colonizing organisms like B. cepacia can be catastrophic in immunocompromised postrenal transplant individuals causing severe urinary tract infection. In the presented case, following 2 weeks of IV antibiotics, the patient didn’t show clinical response, and FDG PET scan recognized multifocal infective sites early, likely representing immune reconstitution inflammatory syndrome and timely appropriate and optimal treatment salvaged the renal graft.

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Cytomegalovirus and Burkholderia cepacia complex prostatitis: Hickam's dictum in a post-renal transplant patient

Cited by 4 publications

References 10 publications

Native kidney cytomegalovirus nephritis and cytomegalovirus prostatitis in a kidney transplant recipient

Native kidney cytomegalovirus nephritis and cytomegalovirus prostatitis in a kidney transplant recipient

Reclaiming the Human Rights Foundations of the UN Standards of Conduct for Business on Tackling Discrimination against LGBTI People

Multifocal Burkholderia cepacia Infection in Postrenal Transplantation Fever

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