Cytomegalovirus and Herpes Simplex Infections in Mothers and Newborns in a Havana Maternity Hospital

Abstract

INTRODUCTION Cytomegalovirus and herpes simplex virus are associated with congenital or perinatal infection, causing potential damage to the newborn.OBJECTIVES Determine the prevalence of active or latent infection by cytomegalovirus and herpes simplex virus in a population of mothers, congenital infection by these agents in their infants, and association between prevalence of virus infection in mothers and in their newborns.METHODS A cross-sectional study was conducted from June to September 2012 in a population of 95 pregnant women admitted to the Dr Ramón González Coro University Maternity Hospital during the third trimester of pregnancy, and their infants (98). Patients were tested for antibodies specifi c to these viruses; vaginal swabs and urine from the women and serum and urine from the newborns were tested for viral genome. The Fisher exact test with 95% confi dence interval was used for comparisons. RESULTSOf the women studied, 89.5% tested positive for cytomegalovirus and 83.2% for herpes simplex. Active infection from cytomegalovirus was detected in 16.7%, and from herpes simplex in 3.2%. Congenital cytomegalovirus infection was detected in 4.1% of newborns; no herpes simplex virus infection was found in this group. Two newborns of women with active cytomegalovirus infection were congenitally infected.CONCLUSIONS Serology demonstrated that most of the women were immune to both viruses. Active cytomegalovirus infections are common in this population, and newborns of women with active cytomegalovirus infection during pregnancy are at increased risk of congenital infection.

Seroepidemiology study of Cytomegalovirus and Rubella in pregnant women in Luanda, Angola: geospatial distribution and its association with socio-demographic and clinical-obstetric determinants

“…Concerning CMV seroprevalence in pregnant´s women, studies in the African continent showed high rates in East Africa (72–89%) and even higher North, Southern and West (100%) [ 11 ]. The seroprevalence of CMV among our patients is similar to that reported from other developing countries, both African [ 12 – 20 ] and non-African [ 19 – 24 ] but higher than the prevalence in developed countries [ 25 – 32 ]. The lower levels of education and socioeconomic status as well as the higher prevalence of poor hygienic conditions in developing countries could be factors associated with the higher prevalence of CMV in these countries [ 33 – 35 ].…”

Study Physiology and Immunology Emergency Clinic Diseases in Patients Experiencing Clinical Consideration and Contamination.

“…In view of broad investigations in the USA and Europe, apparently the power of disease with HCAI disorder ran from 13.0 to 20.3 scenes per thousand days of patients [3]. Contaminations that are acquired by means of the placenta because of certain maladies, for example, rubella, toxoplasmosis, cytomegalovirus or syphilis, and seem 48 hours after birth [6]. Medical clinic obtained diseases showed up before the foundation of emergency clinics and turned into a medical issue during the marvel of anti-microbials.…”