Cytomegalovirus Antibodies in Donors of Fresh Blood to Patients Submitted to Open-Heart Surgery

Klemola, E; R, von Essen; Paloheimo, J.; Furuhjelm, U.

doi:10.3109/inf.1969.1.issue-3.01

Cited by 26 publications

(4 citation statements)

References 13 publications

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“…In Cambridge we found 84 %/O, in Boston there were 86 % (Craighead, 1969), in Washington 81 % (Rowe et al 1956) and in Bristol there were 86 % (Caul et al 1971). When younger patients are included in the groups the total is again similar -Cambridge 66 %, Boston 65 %, Bristol 64 %, in blood donors in Rumania 64 % (Diosi, Moldovan & Tomescu, 1969) and in Finland 66 % (Klemola, von Essen, Paloheimo & Furuhjelm, 1969).…”

Section: Discussionmentioning

confidence: 51%

“…Kanich & Craighead (1966) did not find evidence of CMV infection in those renal transplant patients not given immunosuppressives. However, immunosuppressed patients are rendered susceptible to fresh infection as is only too well known and their environment contains infective CMV (Craighead, 1969) as well as do many of the kidneys transplanted and at least 5 % of units of fresh blood they may be given (Diosi et al 1969;Henle et al 1970;Klemola et al 1969). The situation is more complex than post-perfusion for openheart surgery where primary infections have been described (Henle et al 1970;Lang & Hanshaw, 1969;Paloheimo et al 1968) yet even here reactivation is thought to be a factor by some (Klemola et al 1969;Caul et al 1971) whilst others maintain reactivation is the main factor (Purcell et al 1971).…”

Section: Discussionmentioning

confidence: 99%

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Cytomegalovirus antibody production in renal transplant patients

Nagington

1971

Epidemiol. Infect.

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SUMMARYSera were examined from 50 patients on the renal transplant unit, Cambridge, for antibody against cytomegalovirus by complement fixation and by immunofluorescence for IgG and IgM antibodies.The incidence of antibody on admission was 84 % with a possible further 8 % so that nearly all had been infected at some time by CMV. 43 (86 %) patients showed evidence of active infection after admission, 39 by serology and four only from the examination of post-mortem material.Twenty-one patients produced IgM antibody and production was prolonged for years in patients that survived. Antibody production was related both to transplantation and admission to hospital.The evidence indicated that primary CMV infections were rare, that IgM antibody production was the result of active infection and that this could be attributed to reactivation without the need to invoke re-infection as the source although this type of patient is both susceptible and exposed to re-infection.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus antibody production in renal transplant patients

Nagington

1971

Epidemiol. Infect.

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“…It is known that CMV-mononucleosis can develop after transfusion of fresh blood from a carrier (Klemola et al, 1969;Prince et al, 1971), so there was a strong possibility of this transmission route in our case.…”

mentioning

confidence: 64%

Cytomegalovirus-mononucleosis in a newborn infant.

Umetsu¹,

Chiba²,

Horino³

et al. 1975

Archives of Disease in Childhood

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“…In the late 1960s the linkage of CMV infection with the postperfusion syndrome in transfused cardiac surgery patients emphasized the similarity of this disease entity with classical infectious mononucleosis and resulted in numerous studies to assess the incidence of CMV infections and associated morbidity following transfusion. At least 18 prospective studies have been published in the past 20 years [l, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Cardiac surgery patients have comprised the majority of the study subjects.…”

Section: Transmission By Blood Transfusion To Immunocompetent Recmentioning

confidence: 99%

Transfusion‐Transmitted Cytomegalovirus Infections: Significance and Control

Tegtmeier¹

1986

Vox Sanguinis

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Cytomegalovirus (CMV) is a herpes virus which can give rise to primary infections, reactivated infections, or reinfections in humans. Seroepidemiologic studies have shown CMV infection to be worldwide with the highest antibody prevalences detected in Third World countries; however, significant regional variations can be seen within a given country. Antibody prevalence varies directly with age and inversely according to socioeconomic status. Numerous prospective studies of blood transfusion recipients carried out since 1966 have shown marked differences in infection rates but relatively little associated disease. Infection rates were highest in seronegative recipients given large amounts of fresh blood. Recently published reports have shown substantially lower infection rates than earlier studies, a change likely to be due to the current practice of transfusing fewer units of older blood. CMV has not been found to play a significant role in the etiology of posttransfusion hepatitis. CMV infections have been found to be an important source of morbidity and mortality in immunocompromised patients. Several studies of transfused, premature infants have shown significant differences in infection rates and disease expression. Seronegative low-birth-weight infants receiving blood from seropositive donors are at greatest risk. Blood from CMV-seronegative donors substantially lowers the risk of infection. Receiving a kidney or heart from a CMV-seropositive donor appears to be a more salient risk factor than blood transfusion in renal and cardiac transplant patients who are also more likely to have symptomatic CMV infections. Leukocyte transfusions have been found to be a significant source of CMV infection and disease in bone marrow transplant patients.(ABSTRACT TRUNCATED AT 250 WORDS)

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Cytomegalovirus Antibodies in Donors of Fresh Blood to Patients Submitted to Open-Heart Surgery

Cited by 26 publications

References 13 publications

Cytomegalovirus antibody production in renal transplant patients

Cytomegalovirus antibody production in renal transplant patients

Cytomegalovirus-mononucleosis in a newborn infant.

Transfusion‐Transmitted Cytomegalovirus Infections: Significance and Control

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