Cytomegalovirus-Associated Glomerulonephritis in a Kidney Transplant Recipient

Moysés-Neto, Miguel; Costa, R. S.; Frezza, Gustavo; Garcia, Tânia Marisa Pisi; Nardin, Maria Estela Papini; Romão, Elen Almeida

doi:10.1177/1526924818800034

Cited by 1 publication

(1 citation statement)

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“…Interestingly, lymphocytic interstitial inflammation and necrosis, to some degree, were also reported by several authors [30,35,37,38,41,44,50]. In kidney transplant recipients, CMV mainly causes tubulointerstitial nephritis, with cytopathic changes in tubular epithelial and endothelial cells; inflammation-free cytopathic changes in glomerular endothelial cells and podocytes have been reported in 30% of patients [66] but very rarely do they cause clinically significant glomerulopathy [9,67]. Disseminated infections are common in severe cCMV infections, and inflammation and necrosis have been demonstrated as well in different tissues [30].…”

Section: Discussionmentioning

confidence: 68%

Renal Involvement in Congenital Cytomegalovirus Infection: A Systematic Review

Ríos-Barnés¹,

Fortuny

Alarcón

et al. 2021

Microorganisms

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Background: Congenital cytomegalovirus (cCMV) infection is the most frequent mother-to-child transmitted infection worldwide and a prevalent cause of neonatal disease and long-term morbidity. The kidney is a target organ for CMV, which replicates in renal tubules and is excreted in large quantities in urine for years in children with cCMV infection. Nonetheless, kidney disease has rarely been reported in cCMV-infected patients. Objective: We aimed to describe the available data on renal involvement in patients with cCMV infection at the pathologic, functional, anatomical, and/or clinical levels. Methods: A systematic search was performed in the MEDLINE/PubMed, SCOPUS, and Cochrane databases. Studies describing any renal involvement in fetuses or neonates aged ≤3 weeks at diagnosis of microbiologically confirmed cCMV infection were eligible. Results: Twenty-four articles were included, with a very low level of evidence. Pathologic findings in autopsy studies universally described CMV typical inclusion bodies in tubular cells. No functional studies were identified. cCMV infection was not associated with an increased risk of kidney malformations. Congenital nephrotic syndrome was the most common clinical condition associated with cCMV, but a causal relationship cannot be established. Conclusions: Typical pathological features of cCMV infection are very common in renal tissue, but they do not seem to entail significant consequences at the anatomical or clinical levels.

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