Cytomegalovirus (CMV) Infection and Latency

O’Connor, Christine M.

doi:10.3390/pathogens10030342

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…After the resolution of the primary infection, CMV establishes latency in various organs and tissues throughout the human body [77]. The latent CMV genome, residing in various organs, serves as the molecular foundation for CMV reactivation across multiple organ systems [78,79]. These sites of latency are where the virus remains dormant, without causing active infection or manifest symptoms.…”

Section: Sites Of CMV Latencymentioning

confidence: 99%

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Müller,

Di Benedetto

2024

IJMS

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Aging induces numerous physiological alterations, with immunosenescence emerging as a pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting profound questions about its implications for health and disease. Among the contributing factors, one intriguing actor in this complex interplay is human cytomegalovirus (CMV), a member of the herpesvirus family. Latent CMV infection exerts a profound influence on the aging immune system, potentially contributing to age-related diseases. This review delves into the intricate relationship between immunosenescence and CMV, revealing how chronic viral infection impacts the aging immune landscape. We explore the mechanisms through which CMV can impact both the composition and functionality of immune cell populations and induce shifts in inflammatory profiles with aging. Moreover, we examine the potential role of CMV in pathologies such as cardiovascular diseases, cancer, neurodegenerative disorders, COVID-19, and Long COVID. This review underlines the importance of understanding the complex interplay between immunosenescence and CMV. It offers insights into the pathophysiology of aging and age-associated diseases, as well as COVID-19 outcomes among the elderly. By unraveling the connections between immunosenescence and CMV, we gain a deeper understanding of aging’s remarkable journey and the profound role that viral infections play in transforming the human immune system.

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Section: Sites Of CMV Latencymentioning

confidence: 99%

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Müller,

Di Benedetto

2024

IJMS

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“…After resolution of primary infection CMV establishes latency in various organs and tissues throughout the human body [75]. The latent CMV genome residing in various organs serves as the molecular foundation for CMV reactivation across multiple organ systems [76,77]. These sites of latency are where the virus remains dormant, without causing active infection or manifest symptoms.…”

Section: Sites Of CMV Latencymentioning

confidence: 99%

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Müller,

Di Benedetto

2023

Preprint

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Aging induces numerous physiological alterations, with immunosenescence emerging as a pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting pro-found questions about its implications for health and disease. Among the contributing factors, one intriguing actor in this complex interplay is human cytomegalovirus (CMV), a member of the herpesvirus family. Latent CMV infection exerts a profound influence on the aging immune system, potentially contributing to age-related diseases. This review delves into the intricate relationship between immunosenescence and CMV, revealing how chronic viral infection im-pacts the aging immune landscape. We explore the mechanisms through which CMV can im-pact both the composition and functionality of immune cell populations and induce shifts in in-flammatory profiles with aging. Moreover, we examine potential role of CMV in such pathol-ogies as cardiovascular diseases, cancer, neurodegenerative disorders, COVID-19, and Long COVID. This review underlines the importance of understanding the complex interplay be-tween immunosenescence and CMV. It offers insights into the pathophysiology of aging and age-associated diseases, as well as COVID-19 outcomes among the elderly. By unraveling the connections between immunosenescence and CMV, we gain a deeper understanding of aging's remarkable journey and the profound role that viral infections play in transforming the human immune system.

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“…HCMV, the most studied human beta-herpesvirus, is a ubiquitous virus that causes lifelong infection in humans. It replicates in leukocytes and vascular endothelial cells and persists latently in bone marrow progenitor cells and myeloid cells [ 105 , 106 ]. HCMV is the most important etiological agent of congenital anomalies of the CNS induced by an intrauterine infection in humans [ 107 ].…”

Section: Flavonoids Target Human Herpesviruses Of the Nervous Systemmentioning

confidence: 99%

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

Šudomová¹,

Berchová‐Bímová

Mazuráková

et al. 2022

Viruses

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Human herpesviruses (HHVs) are large DNA viruses with highly infectious characteristics. HHVs can induce lytic and latent infections in their host, and most of these viruses are neurotropic, with the capacity to generate severe and chronic neurological diseases of the peripheral nervous system (PNS) and central nervous system (CNS). Treatment of HHV infections based on strategies that include natural products-derived drugs is one of the most rapidly developing fields of modern medicine. Therefore, in this paper, we lend insights into the recent advances that have been achieved during the past five years in utilizing flavonoids as promising natural drugs for the treatment of HHVs infections of the nervous system such as alpha-herpesviruses (herpes simplex virus type 1, type 2, and varicella-zoster virus), beta-herpesviruses (human cytomegalovirus), and gamma-herpesviruses (Epstein–Barr virus and Kaposi sarcoma-associated herpesvirus). The neurological complications associated with infections induced by the reviewed herpesviruses are emphasized. Additionally, this work covers all possible mechanisms and pathways by which flavonoids induce promising therapeutic actions against the above-mentioned herpesviruses.

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Cytomegalovirus (CMV) Infection and Latency

Abstract: Cytomegalovirus (CMV) is a herpesvirus that infects a majority of the human population worldwide. [...]

Cited by 5 publications

References 7 publications

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

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