Cytomegalovirus DNA identified in skin biopsy specimens of patients with vitiligo

Grimes, Pearl E.; Sevall, J. Sanders; Vojdani, Aristo

doi:10.1016/s0190-9622(96)90490-9

Cited by 81 publications

(70 citation statements)

References 35 publications

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“…[13][14][15][16][17][18][19][20] Experimental data support the role of T-cells within active inflammatory lesions of vitiligo in initiating apoptosis of melanocytes. [13][14][15] Abnormal interactions between melanocytes and surrounding keratinocytes resulting from a decrease in the melanogenic cytokines produced by the keratinocytes, or from downregulation of specific receptors on the surface of melanocytes have been considered as possible pathways in pathogenesis of hypopigmentation in vitiligo.…”

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confidence: 79%

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

et al. 2006

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Hypopigmented mycosis fungoides is an uncommon clinical variant of cutaneous T-cell lymphoma. We hypothesized that hypomelanosis in hypopigmented mycosis fungoides may have a similar mechanism as in vitiligo, a condition in which it is believed that alterations in expression of CD117 (stem cell factor receptor/KIT protein) on epidermal melanocytes and abnormal interactions between melanocytes and surrounding keratinocytes may play a pathogenic role. To test the hypothesis that similar mechanisms might also explain hypopigmentation in hypopigmented mycosis fungoides, skin specimens from five cases each of hypopigmented mycosis fungoides and vitiligo were studied immunohistochemically for immunophenotype of the infiltrating cells, CD117 (expressed by epidermal melanocytes), and pan melanoma cocktail of antigens (gp100, tyrosinase, and MART-1) expression; cases of conventional mycosis fungoides and normal skin were studied in parallel as controls. Our findings confirm a predominance of CD8 þ neoplastic T cells in hypopigmented mycosis fungoides. Similarly, the epidermal lymphocytic infiltrate in vitiligo was also composed of CD8 þ cytotoxic T cells, in contrast to an epidermal infiltrate composed of CD4 þ T cells in conventional mycosis fungoides. The average number of epidermal CD117 expressing cells followed the same pattern of decreased expression in hypopigmented mycosis fungoides as in vitiligo, whereas the levels in conventional mycosis fungoides were higher, and similar to that observed in normal skin. Furthermore, a decreased number of melanocytes per high-power field of the length of the biopsy was present in hypopigmented mycosis fungoides and vitiligo, as compared with either conventional mycosis fungoides or normal skin, suggesting a correlation between decreased expression of CD117 and decreased number of melanocytes. We propose that decreased expression of CD117 and its downstream events in melanocytes may be initiated by cytotoxic effects of melanosomal-antigen-specific CD8 þ neoplastic T lymphocytes, resulting in destabilization of CD117 and leading to dysfunction and/or loss of melanocytes in the epidermis of hypopigmented mycosis fungoides.

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confidence: 79%

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

et al. 2006

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“…Dentre nove pacientes com sorologia positiva para o HTLV-1, identificados em um grupo de 1229 pacientes atendidos em clínica dermatológica, Nobre encontrou dois casos de vitiligo (dados não publicados). Entretanto, Grimes e colaboradores 32 encontraram apenas o citomegalovírus (38% dos casos), ao pesquisarem diversos agentes virais, pela técnica de PCR, na pele de 29 pacientes com vitiligo. A pesquisa do HTLV-1 revelouse negativa, na pele, em todos os casos.…”

Section: Vitiligounclassified

Lesões dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)

Nobre

Guedes

Proietti

et al. 2005

Rev. Soc. Bras. Med. Trop.

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RESUMO O vírus linfotrópico humano de células T do tipo 1 (HTLV-1) é o primeiro retrovírus isolado do ser humano. Descreveuse, em pouco tempo, o seu papel etiológico em algumas doenças, com destaque para a leucemia/linfoma de células T do adulto (ATLL), a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a uveíte associada ao HTLV-1 (HAU). Na década de 90, o HTLV-1 foi associado a eczema grave da infância, conhecido como dermatite infecciosa (DI). Desde então, diversos outros tipos de lesões cutâneas têm sido observados em pacientes infectados pelo HTLV-1, em especial, nos doentes de HAM/TSP ou de ATLL. Porém, mesmo portadores assintomáticos do vírus apresentam doenças dermatológicas. Excetuando-se a dermatite infecciosa, não há lesão da pele específica da infecção pelo HTLV-1. Aqui, os autores apresentam as principais lesões dermatológicas descritas em pacientes infectados pelo HTLV-1, destacando o valor epidemiológico e clínico desses achados. Palavras-chaves: HTLV-1. Retrovírus. ATLL. HAM/TSP. Lesões dermatológicas. Pele. ABSTRACT Human T-cell Lymphotropic vírus type I (HTLV-1) was the first human retrovírus described. Some time after its discovery a group of diseases were related to this vírus, such as, adult T-cell leukemia lymphoma (ATLL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 associated uveitis (HAU). In the nineties, HTLV-1 was associated to a severe eczema of children, called infective dermatitis (ID

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“…It has been demonstrated that epidermal melanocytes are important targets of viral infection (Harson and Grose, 1995). In fact, several studies have linked the pathogenesis of vitiligo to the infection of a variety of viruses, such as cytomegalovirus, hepatitis virus, and HIV (Duvic et al, 1987;Grimes et al, 1996;Tsuboi et al, 2006). However, the exact mechanism of viral infection leading to vitiligo has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Differential Responses of Normal Human Melanocytes to Intra- and Extracellular dsRNA

Wang

Liu

Jin

et al. 2015

DNA and Cell Biology

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Cytomegalovirus DNA identified in skin biopsy specimens of patients with vitiligo

Cited by 81 publications

References 35 publications

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

Lesões dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)

Differential Responses of Normal Human Melanocytes to Intra- and Extracellular dsRNA

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