Cytomegalovirus encephalitis associated with thymoma and immunoglobulin deficiency

Kauffman, Carol A.; Linnemann, Calvin C.; Alvira, Mariano M.

doi:10.1016/0002-9343(79)90274-2

Cited by 31 publications

(9 citation statements)

References 19 publications

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“…20 Only 1 patient had been reported previously with CMV encephalitis. 7 This patient had progressive neurologic decline over 8 months, and diagnosis was made by brain biopsy on the basis of the presence of cytomegalic astrocytes with intracytoplasmic and intranuclear inclusion bodies. However, neither immunostaining nor culture was performed on the biopsy specimen.…”

Section: Discussionmentioning

confidence: 99%

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Fatal Subacute Cytomegalovirus Encephalitis Associated With Hypogammaglobulinemia and Thymoma

Cucchiara

Forman

McGarvey

et al. 2003

Mayo Clinic Proceedings

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Parathymic syndromes are systemic disorders that occur in association with thymoma. One such parathymic syndrome, hypogammaglobulinemia, was initially identified by Good in 1954 and has been referred to as Good syndrome. Patients with this syndrome develop a variety of recurrent infections due to the associated immunodeficiency. We describe a patient with cytomegalovirus encephalitis associated with Good syndrome and discuss the pathologic findings present on autopsy. The possibility of a cytomegalovirus infection should be considered early in the evaluation of patients with Good syndrome if appropriate clinical symptoms are present.

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Section: Discussionmentioning

confidence: 99%

“…6 Previous case reports have described patients with Good syndrome and cytomegalovirus (CMV) infection, including a single previous report of probable CMV encephalitis. 7 We describe a patient with CMV encephalitis associated with Good syndrome, which to our knowledge is the first reported case with autopsy correlation.…”

mentioning

confidence: 83%

Fatal Subacute Cytomegalovirus Encephalitis Associated With Hypogammaglobulinemia and Thymoma

Cucchiara

Forman

McGarvey

et al. 2003

Mayo Clinic Proceedings

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“…6 35 In addition, one case report of a patient with CMV encephalitis showed that the patient had a reduction in specific T cell proliferative responses to CMV in the presence of a normal T cell proliferation to PHA. 36 The immunological findings in Good's syndrome have several limitations. Data on immune function are derived from case reports or small series.…”

Section: Immunologymentioning

confidence: 99%

What is Good's syndrome? Immunological abnormalities in patients with thymoma

Kelleher

Misbah²

2003

Journal of Clinical Pathology

248

254

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“…It may be associated with hemorrhagic and necrotizing foci. This pathological type has been described in AIDS (Morgello et al, 1987;Haw1ey et al, 1983) ad other immune deficiency states (Kauffman et al, 1979).…”

Section: Neurological Diseasementioning

confidence: 71%

Cytomegalovirus

1991

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All rights reserved 90-14345 CIP No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Preface to the First EditionAlthough there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (197la). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the Iiterature and provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries.This book is not an exhaustive review of all the literature. This is probably no Ionger possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.I visualize this work as being useful for physicians, scientists, and students interested in the biology of and infection by human cytomegalovirus. I feel that to understand these, the basic virology of this virus and related herpesviruses must be included. Topics that have not advanced a great deal and that are adequately described in available works, such as the anatomic pathology, have not been reviewed in detail. The emphasis has been placed on newer insights in the virology, immunology, serology, epidemiology, and especially clinical aspects of human cytomegalovirus. I wish tobring out the interactions of knowledge in these areas. Part II is a much shorter treatment of the nonhuman cytomegaloviruses, reviewed primarily from the point of view of their contribution to the understanding of the human virus. V vi Preface to the First Edition Finally, I wish to thank Drs. Charles R. Rinaldo, Jr., John A. Armstrong, and Donald N. Medearis for their critical review of the manuscript. Their suggestions were invaluable. Dr. John N. Dowling's thorough review of CMV infection in patients with malignancies was the basis of Section 13.4. I also acknowledge the indispensable and patient secretarial assistance of Ms.The remarkable medical events and advances in knowle...

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Cytomegalovirus encephalitis associated with thymoma and immunoglobulin deficiency

Cited by 31 publications

References 19 publications

Fatal Subacute Cytomegalovirus Encephalitis Associated With Hypogammaglobulinemia and Thymoma

Fatal Subacute Cytomegalovirus Encephalitis Associated With Hypogammaglobulinemia and Thymoma

What is Good's syndrome? Immunological abnormalities in patients with thymoma

Cytomegalovirus

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