Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix

Ng, Siew C.; Noursadeghi, Mahdad; Herbay, A. von; Vaizey, C. J.; Pitcher, Maxton; Flanagan, Katie L.

doi:10.1016/j.jinf.2006.09.010

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Similarly, Krajicek et al described a patient with perforated CMV gastritis who was diagnosed with diffuse large B-cell lymphoma [ 47 ]. Ng et al reported a case of CMV ileitis and a coexisting metastatic goblet cell carcinoid tumor [ 117 ], while Murakami et al depicted a patient with CMV esophagitis and early esophageal cancer [ 118 ]. In three case series of CMV GI disease, a total of 12 patients were described as having successive (four as “recent”, without anti-tumor therapy) diagnoses of malignancies months after the CMV disease, involving the lung, biliary tract, pancreas, kidney, etc.…”

Section: Resultsmentioning

confidence: 99%

Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review

Yeh,

Wu,

Chen

et al. 2024

Viruses

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Cytomegalovirus (CMV) is a potential pathogen that causes gastrointestinal (GI) tract diseases regardless of host immunity. In contrast to immunocompromised individuals, immunocompetent patients lack a comprehensive overview of the gastrointestinal manifestations. This study aims to provide a comprehensive summary of the current evidence regarding presentations, diagnostics, management, risk assessment, and outcomes in immunocompetent patients with CMV GI disease. A thorough literature search of English publications up to April 2022 was conducted across electronic databases to identify relevant articles, with eligible case series selected for detailed analysis. The majority of immunocompetent patients affected by CMV GI disease are typically elderly, critically ill, or burdened with comorbidities that compromise immunity. Clinical presentations range from subtle symptoms to severe surgical conditions, including instances of mortality. Specific clinical presentations, blood test results, or endoscopic features are lacking, necessitating reliance on histopathological tests such as immunohistochemistry staining for diagnosis. While antiviral therapy may offer benefits in improving outcomes, careful individual assessment is warranted due to diverse comorbidities and potential side effects. Mortality rates vary considerably based on underlying medical conditions and therapeutic approaches. It is imperative for clinicians to maintain vigilance for CMV GI disease among high-risk groups, despite their baseline immunocompetence, in order to enhance clinical outcomes.

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Section: Resultsmentioning

confidence: 99%

Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review

Yeh,

Wu,

Chen

et al. 2024

Viruses

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“…Of the small number of appendiceal carcinoids, only 6% are goblet cell tumors. 7 When evaluating bowel abnormalities, sonography has yet to approach the usefulness of computed tomography (CT). For evaluating the vermiform appendix, CT is considered the gold standard for clinicians.…”

Section: Discussionmentioning

confidence: 99%

Goblet Cell Carcinoid of the Appendix

Magner

Owens²

2007

Journal of Diagnostic Medical Sonography

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A woman in her early 40s presented with a twoday history of nonspecific pelvic pain. Laboratory analysis reported negative BhCG and a white blood count of 16.2, which was elevated. A sonogram of the pelvis was completed. It demonstrated a fibroid uterus and normal ovaries. In the right adnexa, there was a noncompressible tubular structure in the right lower quadrant that extended into the right adnexal region from the cecum adjacent to the right ovary but separate from the right ovary. There was no flow within this structure. The mass was fluid filled with a small amount of debris within. It measured 1.16 cm in transverse diameter and was at least 4 cm in length. This was consistent with appendicitis.The patient was evaluated by a surgeon. She was admitted and had an appendectomy. Pathologic evaluation of the appendix revealed goblet cell carcinoid (GCC) of the appendix with appendicitis.Goblet cell carcinoid (GCC) of the appendix is a rare neoplasm that shares histological features of both adenocarcinoma and carcinoid tumor. In this case, a sonogram of a patient was performed to evaluate adnexal pain, which resulted in the finding of an abnormal appendix. The patient had surgical intervention for appendicitis, which was pathologically confirmed with the addition of GCC. Evaluation of the appendix is warranted if the source of the adnexal pain is not discovered and is indicated clinically.

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Cytomegalovirus duodenitis in immunocompetent patients: what else should we look for?

Costa¹,

Fernandes

Furtado

et al. 2017

BMJ Case Reports

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Cytomegalovirus (CMV) infection is a well-recognised complication of immunodeficiency, although the burden of CMV disease in immunocompetent adults is still unknown. We present the case of a 54-year-old male patient admitted due to severe diarrhoea, epigastric pain and fever. Initial diagnostic workup revealed pericardial and pleural effusion, enlarged abdominal lymph nodes and mild elevation of liver enzymes. CMV serology was IgM positive, and upper endoscopy revealed proximal enteritis. Histology and immunohistochemistry of duodenal samples confirmed CMV disease. An extensive investigation of possible immunodeficiency was conducted with positron emission tomography (PET) scan revealing an abnormal hypermetabolic pulmonary nodule. The patient underwent a right superior lobectomy which, on analysis, confirmed an atypical bronchopulmonary carcinoid tumour. We report this case to reinforce the importance of considering CMV infection as a differential diagnosis in apparent immunocompetent patients and to emphasise the importance of looking for any condition that may cause any degree of immune dysfunction.

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Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix

Cited by 6 publications

References 14 publications

Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review

Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review

Goblet Cell Carcinoid of the Appendix

Cytomegalovirus duodenitis in immunocompetent patients: what else should we look for?

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