Cytomegalovirus Immunoglobulin G Avidity Index among Blood Donors in Alexandria, Egypt

Gawad, Aleya Abdel; Hashish, Mona H.; Abaza, A; El-Kayal, Aisha

doi:10.21101/cejph.a4157

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…In this study, high rates of CMV infections were reported in children receiving a blood transfusion, and the infection was positively correlated with increasing age and the duration of the thalassemia [55]. These high rates of CMV infections are attributed to the high CMV seroprevalence among blood donors in Egypt, as reported by Gawad et al In their study, 96.6% of blood donors (out of 88 tested blood samples) were CMV seropositive [56].…”

Section: In Blood Transfusion Recipients In the Mena Regionsupporting

confidence: 61%

The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA Region: A Systematic Review

et al. 2019

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Human cytomegalovirus (CMV) is a highly prevalent herpesvirus worldwide. According to the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), CMV infects people of all ages, and by the age of five, approximately one-third of children in the United States are infected. Although the infection is generally asymptomatic, it can cause severe disease in immunocompromised patients, transplant and transfusion recipients, as well as newborn neonates. The objective of this study is to systematically review published literature on CMV in the MENA region to estimate its incidence in the region and describe its epidemiological and clinical significance. The literature was searched through four scientific databases: PubMed, Scopus, Science Direct, and Web of Science. A total of 72 studies from 11 countries satisfied the inclusion criteria, covering a period from 1988–2019. The CMV IgG seroprevalence ranged from 8.7%–99.2% (SD = 38.95%). CMV incidence in these countries ranged between 1.22% and 77% in transplant and transfusion recipients, with an increase in incidence with advanced age. However, the incidence rate was unclear for congenital CMV due to the variability of the reporting. This review highlights the need for more robust and well-designed studies to better estimate CMV incidence in the MENA region, standardize diagnostic criteria, and consider prophylactic and pre-emptive treatments to limit the morbidity and mortality of the disease.

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Section: In Blood Transfusion Recipients In the Mena Regionsupporting

confidence: 61%

The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA Region: A Systematic Review

et al. 2019

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“…2020 [ 121 ] Egypt, Alexandria Voluntary blood donors 88 (96.6%) 0.94 0.93 N/A Gawad et al . 2016 [ 122 ] Egypt, Cairo AML & ALL 28 (39%, active CMV) 0.94 0.93 BMT Zekri et al . 2004 [ 123 ] Egypt, Cairo B-ALL (40) T-ALL (10) (children & adolesc.)…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

Janković

Knežević

Todorović

et al. 2022

Virol J

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Background Although cytomegalovirus (CMV) is not considered tumorigenic, there is evidence for its oncomodulatory effects and association with hematological neoplasms. Conversely, a number of experimental and clinical studies suggest its putative anti-tumour effect. We investigated the potential connection between chronic CMV infection in patients with B-lymphocyte (B-cell) malignancies in a retrospective single-center study and extracted relevant data on CMV prevalences and the incidences of B-cell cancers the world over. Methods In the clinical single-center study, prevalence of chronic CMV infection was compared between patients with B-cell leukemia/lymphoma and the healthy controls. Also, global data on CMV seroprevalences and the corresponding country-specific incidences of B- lineage neoplasms worldwide were investigated for potential correlations. Results Significantly higher CMV seropositivity was observed in control subjects than in patients with B-cell malignancies (p = 0.035). Moreover, an unexpected seroepidemiological evidence of highly significant inverse relationship between country-specific CMV prevalence and the annual incidence of B-cell neoplasms was noted across the populations worldwide (ρ = −0.625, p < 0.001). Conclusions We try to draw attention to an unreported interplay between CMV infection and B-cell lymphomagenesis in adults. A large-scale survey across > 70 countries disclosed a link between CMV and B-cell neoplasms. Our evidence hints at an antagonistic effect of chronic CMV infection against B-lymphoproliferation.

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“…91 Moreover, 96.6 % of the subjects tested positive for HCMV-IgG in a study of voluntary blood donors from the Alexandria Regional Blood Transfusion Centre. 92 In addition, in a study of 130 patients that had breast swelling and either malignant or benign surgical excision, Surendran & Chisthi reported that HCMV-IgG antibodies were detected in all investigated patients. Therefore, they inferred that there was no correlation between HCMV-IgG seropositivity and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of Human Cytomegalovirus in Cancer Patients Undergoing Chemotherapeutic Treatment in Egypt and an Emergent Prevalence of Glycoprotein B-5

Shamsia¹,

Abozahra²,

Baraka³

et al. 2022

J. Pure Appl. Microbiol.

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The human cytomegalovirus (HCMV) is a global opportunistic β-herpes virus causing severe diseases in immune-compromised patients, such as malignant tumor patients, especially those undergoing chemotherapeutic treatment. This study aimed to determine the prevalence of HCMV-DNA in chemotherapeutic treatment naive cancer patients, and after chemotherapy, to compare between conventional nested PCR and ELISA techniques for the detection of HCMV, and to detect glycoprotein B genotypes. Plasma and serum samples before and after three chemotherapy cycles were collected from 49 chemotherapy-naive cancer patients. DNA was extracted from plasma samples using QIAamp® DNA Mini kit. HCMV-DNA was detected using a nested PCR technique. Multiplex nested PCR was used for HCMV-glycoprotein B (gB) genotyping. HCMV-IgG and -IgM were detected using ELISA technique. Thirty one (63.3 %) of the 49 plasma samples of the chemotherapy-naïve cancer patients were positive for HCMV-DNA; 21 of which remained positive after chemotherapy. However, 18 samples were negative of which 16 became positive after chemotherapy. gB-5 was the most common glycoprotein genotype detected (80.6 %), followed by gB-1, gB-3, gB-4, and gB-2. HCMV IgG was detected in the 49 serum samples of chemotherapy-naïve patients, and after exposure to chemotherapy. HCMV-DNA is commonly identified in cancer patients. Its detection after chemotherapy exposure may suggest HCMV reactivation. The most common genotype detected in cancer patients in Egypt is gB-5 in contrast to earlier research. IgG was detected in all patients. This indicates that HCMV is endemic in Egypt, necessitating the development of public awareness campaigns about HCMV infection and preventive strategies.

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Cytomegalovirus Immunoglobulin G Avidity Index among Blood Donors in Alexandria, Egypt

Cited by 5 publications

References 41 publications

The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA Region: A Systematic Review

The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA Region: A Systematic Review

Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

Prognosis of Human Cytomegalovirus in Cancer Patients Undergoing Chemotherapeutic Treatment in Egypt and an Emergent Prevalence of Glycoprotein B-5

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