Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-α, and IL-6 signal dysregulation and neoplasia

Melnick, Michael; Deluca, Krysta A.; Sedghizadeh, Parish P.; Jaskoll, Tina

doi:10.1016/j.yexmp.2013.01.005

Cited by 9 publications

(3 citation statements)

References 54 publications

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“…Of potential relevance to cancer, the HCMV genome and gene expression have been detected in many types of tumors including colorectal carcinoma [Harkins et al, ], prostate cancer [Samanta et al, ], skin cancer [Zafiropoulos et al, ], rhabdomyosarcomas [Price et al, ], breast cancer [El‐Shinawi et al, ], mucoepidermoid carcinoma of salivary glands [Melnick et al, ], neuroblastoma [Wolmer‐Solberg et al, ] and glioblastoma multiforme [reviewed in Dziurzynski et al, ]. Several HCMV genes encode products that have the potential to facilitate tumor growth.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of HCMV and viral load in tumor tissues and peripheral blood of glioblastoma multiforme patients

Santos

Stangherlin

Figueiredo

et al. 2013

Journal of Medical Virology

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Glioblastoma multiforme is the most prevalent and malignant tumor of the central nervous system. In the last few years, accumulating evidence has suggested an association between human cytomegalovirus (HCMV) infection and glioblastoma multiforme. In this study, tumor tissues and peripheral blood of patients with glioblastoma multiforme were examined for the presence of HCMV DNA. Twenty-two fresh surgical brain specimens and 20 peripheral blood samples were analyzed by real-time PCR (qPCR) and hemi-nested PCR (nPCR) for the presence of pp65 and (glycoprotein B) gB viral genomic regions, respectively. HCMV DNA was detected in the majority of the tumor samples analyzed (95% by qPCR and 91% by nPCR). About half of the patients with tumors positive for HCMV also had detectable viral DNA in their peripheral blood (47% by qPCR and 61% by nPCR). Genome copy numbers were determined and in the majority of the tumor samples cellular DNA outnumbers viral DNA (average of 1 infected cell in 33 cells). The gB genotypes were determined in HCMV-positive samples and gB2 was the most prevalent genotype in the tumor and blood samples. The results show a high prevalence of HCMV in glioblastoma multiforme samples reinforcing a possible association between HCMV infection and tumor development.

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Section: Introductionmentioning

confidence: 99%

High prevalence of HCMV and viral load in tumor tissues and peripheral blood of glioblastoma multiforme patients

Santos

Stangherlin

Figueiredo

et al. 2013

Journal of Medical Virology

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“…For qRT‐PCR, four to five E15 + 6 and E15 + 9 control and mCMV‐infected cochleas were pooled, snap frozen, and stored at −80°C. For immmunolocalization analyses, cochleas were fixed for 4 hr in Carnoy's fixative or overnight in 4% paraformaldehyde at 4°C, embedded in paraffin, serially sectioned and stained as previously described (Melnick et al, , , ,).…”

Section: Methodsmentioning

confidence: 99%

CMV‐induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition

Melnick

Jaskoll

2015

Birth Defects Research

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Congenital CMV infection is the major non-genetic cause of sensorineural hearing loss at birth and beyond. Among other pathologies, there is a striking dysplasia/hyperplasia of organ of Corti hair and supporting cells (HC/SC). Using an in vitro embryonic mouse model of CMV-induced cochlear teratogenesis that mimics the known human pathology, and functional signaling network modeling, we tested the hypothesis that CMV disrupts the highly ordered HC/SC pattern by dysregulating Notch and Fgfr3, their cognate ligands and downstream effectors. Several novel emergent properties of the critical lateral inhibition subnetwork became apparent. The subnetwork has classic small-world properties such as short paths between most gene pairs, few long-distance links, and considerable clustering. Concomitantly, the calculated probability that our specific gene expression dataset is from dysplastic organs of Corti is highly significant (p < 1 × 10−12). Further, we determined that the subnetwork has a highly heterogeneous scale-free topology in which the highly linked genes (hubs), Notch and Fgfr3, play a central role in mediating interactions among the less linked genes. This phenomenon has important biologic and therapeutic implications.

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“…Melnick and co-workers discuss the association of CMV and a variety of malignancies and conclude that CMV is an important component of tumorigenesis (8). In primary infection, EBV infects B cells and can cause mucocutaneous manifestations in infectious mononucleosis or acute EBV-associated syndromes such as Gianotti-Crosti syndrome and hemophagocytic syndrome (3,9,10).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Epstein–Barr virus and cytomegalovirus in Bulgarian dental patients

Krasteva¹,

Kisselova²,

Ivanova³

2016

MedInform

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Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-α, and IL-6 signal dysregulation and neoplasia

Cited by 9 publications

References 54 publications

High prevalence of HCMV and viral load in tumor tissues and peripheral blood of glioblastoma multiforme patients

High prevalence of HCMV and viral load in tumor tissues and peripheral blood of glioblastoma multiforme patients

CMV‐induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition

Prevalence of Epstein–Barr virus and cytomegalovirus in Bulgarian dental patients

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