Cytomegalovirus Infection After Renal Transplantation Pulmonary Dysfunction Measured by Decreased Diffusing Capacity for Carbon Monoxide in Patients With Symptomatic and Asymptomatic Infection

Son, Won-gyun; Peset, R; Duipmans, José C.; Mark, T W van der; The, T. H.; Tegzess, A. M.

doi:10.1097/00007890-198707000-00029

Cited by 15 publications

(4 citation statements)

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“…In addition to overt pneumonia with pulmonary infiltrates, CMV may also cause more subtle pulmonary dysfunction. In kidney transplant recipients, van Son et al (5) demonstrated pulmonary dysfunction measured as a decreased diffusion capacity for carbon monoxide (KCOc) in symptomatic as well as asymptomatic kidney transplant recipients with CMV infection. Concomitant activation of complement during CMV infection could be demonstrated (6) and it was speculated that the activation of complement could play a role.…”

Section: Pneumonia In Different Patient Groupsmentioning

confidence: 99%

“…In this respect, CMV could play a distinct role in the development of chronic transplant dysfunction and atherosclerosis (1–4). Furthermore, even in asymptomatic patients, involvement of the lungs and gastrointestinal tract could be demonstrated during CMV viremia (5–7). Symptomatic patients usually have a self‐limiting CMV syndrome consisting of fever, malaise, arthralgia, leukocytopenia, thrombocytopenia, and elevated transaminases.…”

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confidence: 99%

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Pulmonary involvement during cytomegalovirus infection in immunosuppressed patients

Maar

Verschuuren

Harmsen

et al. 2003

Transplant Infectious Dis

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Although cytomegalovirus (CMV) pulmonary involvement after solid organ transplantation is infrequently seen nowadays, CMV pneumonitis is still a potential lethal complication. Introduction of the pp65 antigenemia assay enabled early and rapid diagnosis of CMV viremia in transplant patients prior to symptoms. Also, in asymptomatic patients with CMV viremia, a decreased pulmonary diffusion capacity could be demonstrated. In this review, we discuss clinical and subclinical pulmonary involvement of CMV infection in the immunocompromised host with an emphasis on transplant recipients. The clinical course, diagnosis, therapy, prophylaxis, and pathophysiology of CMV pneumonitis are discussed.

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Section: Pneumonia In Different Patient Groupsmentioning

confidence: 99%

mentioning

confidence: 99%

Pulmonary involvement during cytomegalovirus infection in immunosuppressed patients

Maar

Verschuuren

Harmsen

et al. 2003

Transplant Infectious Dis

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“…Cytomegalovirus is often found in conjunction with other pathogens, and in this patient it is not certain whether the treatment of cytomegalovirus had any impact on clinical outcome. There is evidence to suggest that many asymptomatic patients shedding cytomegalovirus may have subclinical pulmonary involvement (8). Culture of cytomegalovirus may be too sensitive a technique for the diagnosis of clinically significant cytomegalovirus pneumonitis (9).…”

Section: Discussionmentioning

confidence: 99%

Successful Management of Sequential Pulmonary Infections in a Cardiac Transplant Recipient

Galbraith

Preiksaitis

Czekanski

et al. 1990

Canadian Journal of Infectious Diseases and Medical Microbiolog

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A case of a cardiac allograft recipient who had an initial combined pulmonary infection with cytomegalovirus, Aspergillus fumigatus and Nocardia asteroides, successfully treated with liposomal amphotericin B and sulfisoxazole and followed by an episode of respiratory syncytial virus pneumonitis, is presented. This case illustrates the role of computed tomographic imaging in the recognition, diagnosis and monitoring of complex opportunistic pulmonary infections and the benefits of liposomal amphotericin B in the treatment of aspergillosis.

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“…Patients with active CMV infection may show subtle disturbances in organ function, even without clinically manifest CMV disease symptoms. An indicator of subtle disturbances in the lungs is a decrease in pulmonary diffusion for CO (31). Effects of CMV infection on the intestines were shown by an increased intestinal permeability to lactulose (3).…”

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confidence: 99%

A Sensitive Method for Quantifying Cytomegalic Endothelial Cells in Peripheral Blood from Cytomegalovirus-Infected Patients

Kas-Deelen¹,

Harmsen²,

Maar³

et al. 1998

Clin Diagn Lab Immunol

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A sensitive method has been developed for the quantification of cytomegalic endothelial cells (CEC) in peripheral blood (PB) of patients with active cytomegalovirus (CMV) infections. The three subsequent key steps of this method are density centrifugation to enrich endothelial cells (EC) in the mononuclear cell (MNC) fraction, EC-specific staining, and fluorescence-activated cell sorting (FACS) of EC onto adhesion slides. The FACS method was compared with the conventional method of cytocentrifugation of the MNC fraction onto slides, followed by EC-specific staining. The main advantage of the additional steps for the isolation and quantification of CEC in PB by FACS is a 10-times-greater sensitivity than by cytocentrifugation of the MNC fraction alone. The recovery percentages of EC from whole blood were comparable for both methods. Recoveries of EC obtained after FACS were 53% ± 16.5%, (mean ± standard deviation), and recoveries of EC obtained after cytocentrifugation of the MNC fraction were 43% ± 4.3%. In patients with active CMV infection, 5 to 72 CEC were detected by FACS, equivalent to 0.8 to 9.0 CEC/ml of blood. With this method for isolation and quantification, the characterization of CEC in PB of patients with CMV-associated clinical symptoms, as well as the quantification of EC in PB of patients with pathophysiological manifestations involving endothelial damage that are different from those caused by CMV infections, can be performed.

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Cytomegalovirus Infection After Renal Transplantation Pulmonary Dysfunction Measured by Decreased Diffusing Capacity for Carbon Monoxide in Patients With Symptomatic and Asymptomatic Infection

Cited by 15 publications

References 0 publications

Pulmonary involvement during cytomegalovirus infection in immunosuppressed patients

Pulmonary involvement during cytomegalovirus infection in immunosuppressed patients

Successful Management of Sequential Pulmonary Infections in a Cardiac Transplant Recipient

A Sensitive Method for Quantifying Cytomegalic Endothelial Cells in Peripheral Blood from Cytomegalovirus-Infected Patients

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