Cytomegalovirus infection and haemophagocytosis in a patient with congenital nephrotic syndrome

Poyrazoğlu, Hakan; Dursun, İsmail; Baştuğ, Funda; Gündüz, Zübeyde; Akyıldız, Başak Nur; Tülpar, Sebahat

doi:10.1007/s00467-009-1243-5

Cited by 7 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study there were non-statistically signi icant differences between CMV IgM positive-patients vs CMV IgM-negative patients (P>0.05) as regarding all blood laboratory investigations (wbcs, platlete, crp, Serum create, Serum albumin, AST, Alt, serum Na, serum K, serum Ca, serum P). However, there were statistically signi icant decreases in HB (P=0.024) and serum urea nitrogen (P=0.04) in IgM positive-patients compared to IgM-negative patients, This also come in agreement with Poyrazoglu et al [13], who studied Cytomegalovirus infection and haemophagocytosis in a patient with congenital nephrotic syndrome in a 3-month-old girl. We concluded that serofrequency of cytomegalovirus infection in pediatric nephrology unit, Zagazig university hospitals during follow-up was 12% for cmv IgM and 100% for cmv IgG at ns children patients.…”

Section: Discussionsupporting

confidence: 87%

Frequency of cytomegalovirus infection in children with Nephrotic Syndrome

Youssef¹,

Mohammed²,

EL-Behaidy³

et al. 2019

Int J Clin Virol

View full text Add to dashboard Cite

Introduction and aim: Idiopathic nephrotic syndrome (INS) is the most common type of this disease during childhood. Minimal change nephrotic syndrome (MCNS) is the most common histopathological lesion (80-90%) of INS in children and about 90% of patients are steroid responsive, while congenital nephrotic syndrome is disorder that may be caused by several diseases. Intrauterine infections, especially CMV infection, have frequently been incriminated as etiological factors of secondary CNS. The aim of this research was to evaluate the frequency of CMV infection children with active nephrotic syndrome in our pediatric nephrology unit Patients and methods: This descriptive (cross sectional) study was conducted in pediatric nephrology unit, Zagazig University Hospitals and included 60 patients WITH NS in activity; Participants were subjected to, Full history taking, Clinical examination; general & local, Routine laboratory investigations and Serum samples were tested for HCMV specifi c immunoglobulin G (IgG) and immunoglobulin M (IgM) using ELISA Kit. Results: We found 100% of cases were IgG positive and 7/60 cases were IgM positive, There were no statistically signifi cant differences between IgM positive-patients vs IgM-negative patients according to age, sex and fi rst attack or relapsed NS, There were statistically signifi cant differences between IgM positive-patients vs IgM-negative patients in blood laboratory data in decreases in HB (P=0.024) and serum urea nitrogen (P=0.04) Conclusion: We concluded that serofrequency of cytomegalovirus infection in pediatric nephrology unit, Zagazig university hospitals during follow-up was 12% for cmv IgM and 100% for cmv IgG at ns children patients.

show abstract

Section: Discussionsupporting

confidence: 87%

Frequency of cytomegalovirus infection in children with Nephrotic Syndrome

Youssef¹,

Mohammed²,

EL-Behaidy³

et al. 2019

Int J Clin Virol

View full text Add to dashboard Cite

show abstract

“…Until 2018, 7 cases of CMV-associated CNS were reported in other countries, and CMV infection was the only secondary finding. In the 7 patients, 5 patients underwent renal biopsy (9–13), and renal tubular cytomegalovirus inclusion bodies were found in 2 patients (9, 10). Of the 7 patients, 5 were administered with antivirus therapy, and proteinuria in 4 patients disappeared, and their clinical conditions improved after ganciclovir treatment (10, 12, 14).…”

Section: Discussionmentioning

confidence: 99%

“…Of the 7 patients, 5 were administered with antivirus therapy, and proteinuria in 4 patients disappeared, and their clinical conditions improved after ganciclovir treatment (10, 12, 14). However, 1 patient died (13). The remaining 2 patients was not administered antivirus therapy; 1 patient improved after symptom-relieving and supportive treatment (10), and the other showed no response to cyclosporin and corticosteroid therapy (11).…”

Section: Discussionmentioning

confidence: 99%

Analysis of 14 Patients With Congenital Nephrotic Syndrome

et al. 2019

View full text Add to dashboard Cite

From January 1995 to June 2018, 14 patients with congenital nephrotic syndrome (CNS) were diagnosed in the Department of Pediatrics, Peking University First Hospital. The clinical data were retrospectively studied. Eight patients underwent genetic testing; 7 of them had NPHS1 mutations (primary CNS), and 1 did not have a mutation. Of the 7 patients with NPHS1 mutations, 6 died, and 1 had proteinuria. Of the 14 patients, 8 had cytomegalovirus (CMV) infection, and anti-CMV therapy was administered to 7 of them. The other patient was hospitalized in critically ill condition and died before anti-CMV therapy administration. Of the 7 patients who were administered anti-CMV therapy, proteinuria disappeared in 2 patients; 2 patients died; 2 patients were lost to follow up; and 1 patient still had 3+ proteinuria. Three patients had both NPHS1 mutations and CMV infection. After anti-CMV therapy, proteinuria was resolved in 1 patient but relapsed to 3+ proteinuria due to a new infection. The other 2 patients died. Of 14 patients, only 1 patient underwent renal biopsy, with results showing mesangial proliferative glomerulonephritis pathology, negative CMV inclusion body, and CMV-DNA. In this study, genetic defect could play a primary role in CNS, and CMV could play a secondary role. Primary CNS with NPHS1 mutations has a poor prognosis. Primary CNS might be accompanied by CMV infection that responds poorly to antiviral treatment. Secondary CNS caused by CMV infection may be cured with antiviral therapy. However, genetic analysis is necessary to exclude genetic defects.

show abstract

“…Chronic or prolonged infections by several agents, in particular hepatitis B and C, syphilis, toxoplasmosis, AIDS, and cytomegalovirus are some of the causes of secondary nephrotic syndrome 3 , 4 , 5 , 10 , 16 , 20 , 23 , 27 , 28 . On the other hand, frequent use of immunosuppressants in children with kidney disease or kidney transplant recipients make these individuals susceptible to opportunistic infections by intracellular parasites such as cytomegalovirus (CMV) and herpes simplex virus (HSV) 1 or 2 6 , 14 , 21 , 22 .…”

Section: Introductionmentioning

confidence: 99%

Serological Markers of Viral, Syphilitic and Toxoplasmic Infection in Children and Teenagers With Nephrotic Syndrome: Case Series From Mato Grosso State, Brazil

Soares

Donatti

Souto

2014

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

Some infections can be the cause of secondary nephrotic syndrome. The aim of this study was to describe the experience of a Renal Disease Reference Clinic from Central Brazil, in which serological markers of some infectious agents are systematically screened in children with nephrotic syndrome. Data were obtained from the assessment of medical files of all children under fifteen years of age, who matched nephrotic syndrome criteria. Subjects were tested for IgG and IgM antibodies against T. gondii and cytomegalovirus; antibodies against Herpes simplex, hepatitis C virus and HIV; and surface antigen (HBsAg) of hepatitis B virus. The VDRL test was also performed. 169 cases were studied. The median age on the first visit was 44 months and 103 (60.9%) patients were male. Anti-CMV IgG and IgM were found in 70.4% and 4.1%, respectively. IgG and IgM against Toxoplasma gondii were present in 32.5% and 5.3%, respectively. Two patients were positive for HBsAg, but none showed markers for HIV, hepatitis C, or Treponema pallidum. IgG and IgM against herpes simplex virus were performed on 54 patients, of which 48.1% and 22.2% were positive. IgM antibodies in some children with clinical signs of recent infection suggest that these diseases may play a role in the genesis of nephrotic syndrome.

show abstract

Cytomegalovirus infection and haemophagocytosis in a patient with congenital nephrotic syndrome

Cited by 7 publications

References 10 publications

Frequency of cytomegalovirus infection in children with Nephrotic Syndrome

Frequency of cytomegalovirus infection in children with Nephrotic Syndrome

Analysis of 14 Patients With Congenital Nephrotic Syndrome

Serological Markers of Viral, Syphilitic and Toxoplasmic Infection in Children and Teenagers With Nephrotic Syndrome: Case Series From Mato Grosso State, Brazil

Contact Info

Product

Resources

About