Cytomegalovirus infection and postoperative complications in patients with ulcerative colitis undergoing colectomy

Olaisen, Maya; Rydning, Astrid; Martinsen, Tom Christian; Nordrum, Ivar Skjåk; Mjønes, Patricia; Fossmark, Reidar

doi:10.3109/00365521.2014.929172

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…None of the colonic explants had evidence of CMV (0%). This incidence was significantly (Fisher's exact 2-tailed P = 0.0106) lower than in a similar study on adult colectomy specimens (8).…”

Section: Resultscontrasting

confidence: 65%

“…In our analysis of colonic explants, we found no evidence of CMV in pediatric IBD patients requiring colectomy. While CMV colitis is associated with increased rates of colectomy and mortality in adults with UC (8,11), pediatric IBD studies have not shown a significantly increased risk of colectomy at 12 months from this diagnosis (10,24). Our results are consistent with this prior literature.…”

Section: Discussionmentioning

confidence: 99%

“…Like organ transplant recipients, patients with IBD have a higher risk of CMV colitis than the general population (7). Indeed, 11.7% of colectomy specimens from adult ulcerative colitis (UC) patients were retrospectively found to be CMV positive by routine histology and immunohistochemistry (IHC), the incidence of which correlated with age at the surgery (8). All these patients were positive for characteristic viral inclusions of CMV by traditional hematoxylin & eosin (H&E) staining as well.…”

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confidence: 99%

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Routine Histology-Based Diagnosis of CMV Colitis Was Rare in Pediatric Patients

Buck

Cho

Walsh

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Cytomegalovirus (CMV) induced or complicated colitis is important to identify, yet its incidence is unknown among pediatric patients. We aimed to establish the incidence of routine histology-confirmed CMV colitis among pediatric patients with colitis. Pathology reports at Texas Children's Hospital (TCH) between January 1, 2011 and November 6, 2019 were reviewed. Of 1801 cases of histologic colitis, 11 patients had CMV found by histology (mean age 15.4, 72.7% female), with an incidence of 0.6%. Nine out of these 11 (81.8%) patients were immunocompromised and 4 (36.4%) had inflammatory bowel disease (IBD) as an underlying diagnosis of whom 2 had new-onset ulcerative colitis. At an average follow-up of 3.7 years, none of the CMV colitis cases experienced recurrence or severe complications (such as colectomy). An independent analysis of 54 consecutive IBD-associated colectomy cases at TCH showed no histologic evidence of CMV. We conclude that routine histology proven CMV-associated colitis in pediatric patients and IBD-colon explants was rare.

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Section: Resultscontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Routine Histology-Based Diagnosis of CMV Colitis Was Rare in Pediatric Patients

Buck

Cho

Walsh

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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“…[ 7 8 9 ] Recently, some studies also found that Clostridium difficile infection and cytomegalovirus (CMV) reactivation are closely correlated with postoperative outcomes in UC patients. [ 10 11 12 ]…”

Section: Introductionmentioning

confidence: 99%

Preoperative Corticosteroid Usage and Hypoalbuminemia Increase Occurrence of Short-term Postoperative Complications in Chinese Patients with Ulcerative Colitis

Lyu

Yang

et al. 2016

Chinese Medical Journal

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Background:Clarifying the risk factors for postoperative complications and taking measures to minimize these complications will improve the outcomes in patients with ulcerative colitis (UC). This study aimed to systemically explore the risk factors for short-term postoperative complications in Chinese UC patients undergoing ileocolorectal surgery.Methods:Forty-nine UC patients undergoing proctocolectomy or ileostomy were retrospectively enrolled. Univariate and multivariate logistic regression analyses were conducted to reveal the risk factors among the clinical, laboratory, and surgical variables as well as preoperative medications.Results:Twenty-two (44.9%) patients who suffered from at least one short-term postoperative event had more severe hypoalbuminemia (P = 0.007) and an increased prevalence of preoperative corticosteroid usage (prednisone more than 20 mg daily or equivalent) for more than 6 weeks (59.1% vs. 25.9%, P = 0.023) compared with patients without short-term postoperative complications. Based on the multivariate logistic regression analysis, the odds ratio (95% confidence interval) values of these two risk factors were 1.756 (0.889–3.470, P = 0.105) and 3.233 (0.916–11.406, P = 0.068), respectively. In 32 severe UC patients, prolonged preoperative hospital stay worsened the short-term postoperative outcomes.Conclusions:Preoperative corticosteroids usage and hypoalbuminemia worsened the short-term outcomes following ileocolorectal surgery in Chinese UC patients.

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