Cytomegalovirus Infection Associated With Pregnancy

Dioşi, P; Babuşceac, Livia; Nevinglovschi, Olimpia; Kun-Stoicu, G.

doi:10.1016/s0140-6736(67)90338-8

Cited by 77 publications

(12 citation statements)

References 15 publications

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“…Our isolation rate for HSV of 5 -9 per cent in a group of patients attending a venereal diseases clinic supports the findings of other surveys (Diosi et al, 1967;Beilby et al, 1968). By the use of both cytological diagnosis and virus isolation we were able to show a relatively high total incidence of 8 6 per cent.…”

Section: Discussionsupporting

confidence: 91%

An Evaluation of Cytology in the Diagnosis of Herpes Simplex Virus Infection and Cytomegalovirus Infection of the Cervix Uteri

Morse

Coleman

Gardner

1974

BJOG

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A cytological and virological study was made to determine the incidence of herpes simplex virus (HSV) infection and cytomegalovirus (CMV) infection of the cervix uteri in 197 women attending a venereal diseases clinic. Cervical cytology was compared with virus isolation as a means of detecting these infections. Herpes simplex virus was isolated from 11 out of 186 women appropriately tested (5 -9 per cent) and an additional 5 patients (2.7 per cent) showed only cytological evidence of the infection, giving a combined diagnostic rate of 8.6 per cent. Cytomegalovirus was isolated from 12 out of 145 patients suitably tested (8.3 per cent) and an inclusion-bearing cell was identified in one of these patients. An association between CMV and multiple genital warts was noticed.

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Section: Discussionsupporting

confidence: 91%

An Evaluation of Cytology in the Diagnosis of Herpes Simplex Virus Infection and Cytomegalovirus Infection of the Cervix Uteri

Morse

Coleman

Gardner

1974

BJOG

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“…Studies carried out in the past 15 years indicate that breast-feeding and child-rearing practices singly or in combination are two of the most powerful factors influencing the rate of acquisition of CMV in the various populations (7,8 (9) were the first to report the isolation of CMV from human milk. The virus was found in 1 of 49 milk specimens collected from parturient women.…”

Section: The Problemmentioning

confidence: 99%

Working parents: the impact of day care and breast-feeding on cytomegalovirus infections in offspring.

Stagno

Cloud

1994

Proc. Natl. Acad. Sci. U.S.A.

103

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The cease in the poularity of breast feeding and of child care t are having a major effect on the epideilogy ofcytomegalov infections. Under special circumstances fomites may also play a role, since CMV has been shown to retain infectivity for hours on plastic surfaces and has been isolated from randomly selected toys and surfaces in day-care centers (4, 5). Restriction enzyme analyses of CMV DNA have been used to demonstrate route oftransmission of the virus in situations in which close contact occurs, such as breast-feeding, sexual activity, day care, and interaction between parents or caretakers and infected toddlers.The prevalence of CMV infection increases with age, but, according to geographic, ethnic, and socioeconomic backgrounds, the patterns of acquisition of this infection vary widely among populations (6). As illustrated in Fig. 1, CMV is acquired earlier in life in developing countries and among the lower socioeconomic strata of developed countries. Differences between populations can be particularly striking during childhood. Presumably, these significant differences are the reflection of factors that account for increased exposure to CMV such as crowding, breast-feeding, sexual practices, and certain rearing practices.Studies carried out in the past 15 years indicate that breast-feeding and child-rearing practices singly or in combination are two of the most powerful factors influencing the rate of acquisition of CMV in the various populations (7,8 shedding CMV in colostrum while 13 of 31 (42%) had positive milk specimens when sampled between 2 and 12 wk postpartum. As illustrated in Table 1, the acquisition of CMV by Abbreviation: CMV, cytomegalovirus. *To whom reprint requests should be addressed. 2384The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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“…HCMV can be shed for months, if not years, upon infection by numerous body fluids (Cannon et al, 2011), arguing that CMV may naturally transmit itself by more than one means of infection. Numerous studies have shown that HCMV shedding by breast milk (Diosi et al, 1967) may be a way of transmission (Stagno et al, 1980;Dworsky et al, 1983), especially in pre-term infants (Vochem et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection

Oduro

Redeker

Lemmermann

et al. 2016

Journal of General Virology

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Cytomegalovirus (CMV) is a ubiquitous virus, causing the most common congenital infection in humans, yet a vaccine against this virus is not available. Experimental studies of immunity against CMV in animal models of infection, such as the infection of mice with mouse CMV (MCMV), have relied mainly on parenteral infection protocols, although the virus naturally transmits by mucosal routes via body fluids. To characterize the biology of infections by mucosal routes, we compared the kinetics of virus replication, latent viral load and CD8 T-cell responses in lymphoid organs upon experimental intranasal (targeting the respiratory tract) and intragastric (targeting the digestive tract) infection with systemic intraperitoneal infection of two unrelated mouse strains. We observed that intranasal infection induced robust and long-term virus replication in the lungs and salivary glands but limited replication in the spleen. CD8 T-cell responses were somewhat weaker than upon intraperitoneal infection but showed similar kinetic profiles and phenotypes of antigen-specific cells. In contrast, intragastric infection resulted in abortive or poor virus replication in all tested organs and poor T-cell responses to the virus, especially at late times after infection. Consistent with the T-cell kinetics, the MCMV latent load was high in the lungs but low in the spleen of intranasally infected mice and lowest in all tested organs upon intragastric infection. In conclusion, we showed that intranasal but not intragastric infection of mice with MCMV represents a robust model to study the short-and long-term biology of CMV infection by a mucosal route.

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Cytomegalovirus Infection Associated With Pregnancy

Cited by 77 publications

References 15 publications

An Evaluation of Cytology in the Diagnosis of Herpes Simplex Virus Infection and Cytomegalovirus Infection of the Cervix Uteri

An Evaluation of Cytology in the Diagnosis of Herpes Simplex Virus Infection and Cytomegalovirus Infection of the Cervix Uteri

Working parents: the impact of day care and breast-feeding on cytomegalovirus infections in offspring.

Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection

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