Cytomegalovirus Infection Following Extracorporeal Circulation in Children

Embil, J. A.; Folkins, D.F; Haldane, E. V.; Rooyen, C. E. van

doi:10.1016/s0140-6736(68)91635-8

Cited by 63 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This retinitis is probably due to cytomegalovirus for, although no histological evidence of typical inclusion bodies in the retinal cells was available in these cases, the diagnosis was suggested by the fourfold rise in the titre of complement-fixing antibodies to cytomegalovirus and the close clinical similarities between these two cases and a reported case (de Venecia et al, 1971) of acute retinitis in which confirmatory histological evidence was found at necropsy. Cytomegalovirus has been shown to be more widespread in the general population than at one time thought (Stern and Elek, 1965;Embil et al, 1969), and renorts of cytomegalovirus infection in patients after renal transplantation are increasing (Hedley-White and Craighead, 1965;Kanich and Craighead, 1966;Craighead et al, 1967;Rifkind et al, 1967). Most of the patients are asymptomatic and the diagnosis is made by serological tests or by the identification of typical inclusion bodies in cells from the urine (Bossen et al, 1969) or peripheral blood (Armstrong et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

Incidence of Ocular Complications in Patients Undergoing Renal Transplantation

Porter¹,

Crombie²,

Gardner³

et al. 1972

BMJ

View full text Add to dashboard Cite

SummaryThe eyes of 39 patients who had received allogenic renal transplants were examined for signs of disease. Nine (23 %) had early posterior subcapsular cataracts, two (5% ) developed acute cytomegalovirus retinitis, and one developed steroid-induced glaucoma. The lesions which were found were all attributable to the immunosuppressive drug therapy. Thirty-five (870%) had detectable complement-fixing antibodies to cytomegalovirus.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence of Ocular Complications in Patients Undergoing Renal Transplantation

Porter¹,

Crombie²,

Gardner³

et al. 1972

BMJ

View full text Add to dashboard Cite

show abstract

“…infectious mononucleosis-like syndrome, hepatitis, postperfusion syndrome, etc. (Hanshaw et al, 1965;Embil et al, 1968;Klemola et al, 1969Klemola et al, , 1972Jordan et al, 1973). Pneumonia occurs not infrequently in patients dying from CMV infection both in congenital disease (Medearis, 1964;McCracken et al, 1969) and in hosts with altered immunity (Hill et al, 1964;Rifkind et al, 1967).…”

mentioning

confidence: 99%

Pulmonary involvement with cytomegalovirus infections in children.

Smith¹,

Cho²,

Brahmacupta³

et al. 1977

Archives of Disease in Childhood

View full text Add to dashboard Cite

SUMMARY Among 40 hospitalized infants and children with cytomegalovirus infection, 14 (35 %) had interstitial pneumonitis, 4 (10%) had wheezing or tachypnoea but without x-ray evidence of classical interstitial pneumonia, the remaining 22 (55 %) were free of pulmonary involvement. Most patients had tachypnoea and nonproductive cough of varying durations: those with underlying pulmonary pathology tended to have persistent and prolonged respiratory symptoms. Mortality and severity of the lung disease were related to the underlying immunodeficiency or concomitant pulmonary process.Clinical presentations of cytomegalovirus (CMV) infection encompass a broad spectrum of symptoms and signs ranging from asymptomatic disease to lethal congenital infection (Hanshaw et al., 1965;Starr and Gold, 1968). The most common features of congenital infection include hepatosplenomegaly, jaundice, petechiae, low birthweight, and microcephaly (Overall and Glasgow, 1970). Acquired CMV infections are often seen in patients with altered host resistance (Hill et al., 1964;Cangir and Sullivan, 1966;Sutton et al., 1967;Neiman et al., 1973), but these infections may also occur in normal hosts (Klemola et al., 1969; Jordan et al., 1973). Various manifestations of acquired CMV infection have been reported, e.g. infectious mononucleosis-like syndrome, hepatitis, postperfusion syndrome, etc. (Hanshaw et al., 1965;Embil et al., 1968;Klemola et al., 1969Klemola et al., , 1972 Jordan et al., 1973).Pneumonia occurs not infrequently in patients dying from CMV infection both in congenital disease (Medearis, 1964;McCracken et al., 1969) and in hosts with altered immunity (Hill et al., 1964;Rifkind et al., 1967

show abstract

“…Although some earlier reports supported this association, the studies after 1979 showed that most of the post-transfusion hepatitis was not associated with CMV infection [Tegtmeier, 1986al. Our results indicated that transfusion-acquired CMV infec- Paloheimo et al, 1968 CSP 66% Fresh HB <24 hr 10/17 (59%)) Henle and Henle, 1970 CSP NA Fresh HB few hr 36/61 (59%) Embil et al, 1968 CSP NA Fresh CB <24 hr 7/16 (44%) Perham et al, 1971 CSP 55% Fresh HB <36 hr 2/5 (40%) Monif et al, 1976 MP 100% NA mean 9 days 13/54 (24%) Prince et al, 1971 MP NA Banked CB variable 17/93 (18%) Yeager et al, 1981 Neonates 45% Fresh CB <72 hr 10/74 (14%) Adler et al, 1983 Neonates 34% Banked CB <5 days 8/76 (11%) Wilhelm et al, 1986 MP NA Fresh CB NA 6/59 (10%) Lamberson et al, 1988 Neonates tions in immunocompetent recipients did not cause significant morbidity. Only a minority of such infections would be accompanied by deranged liver function and this was clinically insignificant in most cases.…”

Section: Discussionmentioning

confidence: 69%

“…This extremely high rate of CMV infection with the use of fresh seropositive blood was again unusual. The infection rate with the use of fresh blood varied from 10% to 59% in previous reports [Embil et al, 1968;Henle and Henle, 1970;Wilhelm et al, 1986;Paloheimo et al, 1968;Perham et al, 1971;Yeager et al, 19811. It is noteworthy that most of the fresh blood used in present study was used within 24 hours.…”

Section: Discussionmentioning

confidence: 93%

Transfusion‐acquired cytomegalovirus infection in children in a hyperendemic area

Lee

Chang

Hwu

et al. 1992

Journal of Medical Virology

View full text Add to dashboard Cite

Thirty-nine children without previous cytomegalovirus (CMV) infection received blood transfusion in the National Taiwan University Hospital. The overall transfusion-acquired CMV infection rate was 36% (14/39). Donor CMV seropositive rate was 70%. None of the nine children who had received seronegative blood became infected, in contrast to 14 of the 21 children (67%) who had received seropositive blood (P = 0.002). Another significant risk factor associated with CMV infection was the use of fresh blood: 13 of 15 (87%) with fresh seropositive blood were infected, in contrast to one of six (17%) with "old" seropositive blood (P = 0.01). Most of the fresh blood was used within 24 hours. This blood processing method was shown to account for the extremely high rate of CMV infection in those who had received fresh seropositive blood. The results indicated that the incidence of CMV infection can be reduced by avoiding the use of fresh blood, especially blood less than 24 hours old. For such a population in Taiwan with high prevalence of positive CMV antibody, this approach was more applicable than screening donor blood for CMV antibody.

show abstract

Cytomegalovirus Infection Following Extracorporeal Circulation in Children

Cited by 63 publications

References 16 publications

Incidence of Ocular Complications in Patients Undergoing Renal Transplantation

Incidence of Ocular Complications in Patients Undergoing Renal Transplantation

Pulmonary involvement with cytomegalovirus infections in children.

Transfusion‐acquired cytomegalovirus infection in children in a hyperendemic area

Contact Info

Product

Resources

About