Cytomegalovirus Infection in two Infants with Congenital or Neonatal Solid Tumors

Nigro, Giovanni; Bartmann, U.; Properzi, Enrico; Torre, Andrea; Schiavetti, Amalia; Castello, Manuel A.

doi:10.3109/08880019309029515

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…This virus is considered as an important opportunistic infection [26]. Presence of CMV in congenital tumours has also previously been reported, suggesting its role in some neonatal sarcomas’ progression [29]. CMV infection was also detected in testicular cancer of neonates in association with EBV, suggesting the role of viral infection in testicular tumourigenesis [30].…”

Section: Discussionmentioning

confidence: 91%

ecancermedicalscience

Monajemzadeh

Sarmadi

Moeini³

et al.

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Congenital tumours are a group of distinct infrequent disorders whose exact aetiologies have not clearly been understood so far. Viral infection seems to be one of the key factors involved in the carcinogenesis of certain tumours. This study was performed to assess whether viral DNAs are present in the congenital tumours or not. Nucleic acid from 31 congenital tumours was extracted. Detection of Epstein–Barr virus, Cytomegalovirus (CMV), adenovirus, Herpes simplex virus 1 (HSV1) and 2, Human herpes virus 6 (HHV6), and BK virus was performed using polymerase chain reaction. Viral nucleic acid was detected in eight subjects (25.8%), mostly adenovirus, CMV, and HHV6. Despite their low frequencies, a possible role could be identified for viral infections in tumour development or progression.

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Section: Discussionmentioning

confidence: 91%

ecancermedicalscience

Monajemzadeh

Sarmadi

Moeini³

et al.

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Cytomegalovirus‐associated stage 4S neuroblastoma relapsed stage 4

Nigro¹,

Schiavetti

Booth

et al. 1995

Med. Pediatr. Oncol.

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Neuroblastoma is one of the most frequent solid tumors in childhood, rarely recurrent after five years from diagnosis. Cytomegalovirus (CMV), a major pathogen causing congenital birth defects and severe opportunistic diseases, has been shown to have teratogenic, immunodepressive and oncogenic properties. The case of a girl with stage 4S neuroblastoma diagnosed at three months and relapsed as stage 4 five years later is reported. In both circumstances, active CMV infection was revealed by positive CMV-specific IgM and IgA antibodies, CMV-DNAemia and CMV culture. At three months, the patient presented with subcutaneous nodules, hepatosplenomegaly and increased aminotransferase levels, and the opsolonus-myoclonus syndrome. Mental retardation developed later on. At 5 years, relapsed neuroblastoma was preceded by a mononucleosis-like syndrome concomitant with active CMV infection and decreased levels of immune cells and natural killer activity. Clinical, virologic, and immunologic findings suggest an immune-mediated pathogenic role for CMV in this tumor.

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Congenital Tumours

Berry¹,

Charles²

2001

Fetal and Neonatal Pathology

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Cytomegalovirus Infection in two Infants with Congenital or Neonatal Solid Tumors

Cited by 5 publications

References 17 publications

ecancermedicalscience

ecancermedicalscience

Cytomegalovirus‐associated stage 4S neuroblastoma relapsed stage 4

Congenital Tumours

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