Cytomegalovirus Keratitis in Acquired Immunodeficiency Syndrome

No detection of parvovirus B19 or herpesvirus DNA in giant cell arteritis

“…In this regard, herpesviruses are known to produce latent infections (e.g., herpes zoster) and can also lead to T cell-mediated inflammation. Furthermore, some herpesviruses, e.g., Epstein-Barr virus (EBV) (Krueger et al, 1987), herpes simplex virus (HSV) (Teitelbaum et al, 1987), and human cytomegalovirus (HCMV) (Wilhelmus et al, 1996) induce the hallmark pathologic finding of GCA: giant cell formation (Lie, 1990). Finally, varicella-zoster virus (VZV) demonstrates a tropism for blood vessels (Fukumoto et al, 1986), and HCMV and human herpesvirus-6 (HHV-6) may induce endothelial damage (Takatsuka et al, 2003).…”

Sectorial keratitis and uveitis: differential diagnosis

“…A case of a patient with AIDS with bilateral CMV keratitis confirmed by cytopathic features and viral culture has been reported [20]. Initially, the patient had epithelial keratitis, which progressed to sectorial stromal keratitis and iritis in both eyes.…”

Transient Anterior Corneal Deposits in a Human Immunodeficiency Virus-Positive Patient

“…A number of reports have documented the presence of corneal deposits in HIV patients with CMV retinitis [1][2][3] or in patients with systemic CMV infection. [3][4][5] The deposits in these cases have been variably-pigmented (ranging from white to yellow and brown), were located predominantly in the peripheral cornea, 4 and have been invariably confined to the level of Descemet's membrane 4 or corneal endothelium, 1 with the exception of peripheral stromal involvement in one case. 2 Rare epithelial and stromal manifestations of CMV infection have been reported, 5,6 with patients presenting a range of symptoms and exhibiting corneal findings of stromal scarring, edema, and enlarged, infected epithelial cells and stromal keratocytes, with a progressive worsening of the condition.…”