Cytomegalovirus oesophagitis in a patient with non-hodgkin's lymphoma

Hingmire, SS; Biswas, Ghanshyam; Bakshi, Ashish; Desai, Sangeeta; Dighe, Swati; Nair, Reena; Gupta, Sudeep; Parikh, PM

doi:10.4103/0255-0857.38866

Cited by 4 publications

(3 citation statements)

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“…CMV pneumonia (CMVp) is to be one of the most common clinical presentations of CMV disease and is associated with considerable morbidity and mortality in patients with hematological malignancies [30,31]; disease-specific mortality rate reaches up to 30% in lymphoma patients [32]. Moreover, CMV retinitis [33] encephalitis and oesophagitis have been observed among patients with HL and NHL diseases [34]. In contrast to Hingmire et al (34), who reported that CMV infections are less common in HL and NHL patients who did not undergo allogeneic BMT, we could detect CMV infection in 34% of our lymphoma patients.…”

Section: Discussionmentioning

confidence: 99%

Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection

Loutfy

Fawzy

El-Wakil

et al. 2010

Virol J

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BackgroundActivation of herpes virus 6 (HHV6) has seen in Hodgkin's and non-Hodgkin's Lymphoma (HL&NHL) as a result of lymphoma associated immunosuppression. Multiple studies have suggested an association between both HHV6 and cytomegalovirus CMV for development of CMV disease affecting the pathogenesis of lymphoma. Therefore, this study investigated the frequency of HHV6, its impact on clinical manifestations of lymphoma and its possible association with risk for development of CMV infection in pediatric lymphoma patients.MethodsPresence of HHV6 DNA and CMV DNA was investigated by PCR assay in both WBC's and plasma samples from 50 patients diagnosed with HL or NHL. CMV antibody titer was also determined in sera obtained from each patient. Twenty apparently healthy siblings were used as a control group.ResultsIn a study group of 50 patients diagnosed with HL or NHL, 23/50 (46%) were found to be positive for herpes virus DNA (HHV6 or CMV) in WBC's or plasma by PCR assay and this was significantly higher than its presence in the pediatric control group 2/20 (10%) (p = 0.005). Ten out of these 23 (43%) were found to have active CMV infection. Fifty six percent of patients with CMV infection were found among NHL cases with B- subtype. The presence of both herpes viruses DNA was significantly associated with more frequent episodes of febrile neutropenia (median 3 episodes), absolute neutrophil count (< 0.8), lymphocytes (< 0.5), and low hemoglobin level (< 9.1), (p < 0.05).ConclusionThe presence of HHV6 can be considered as a predicting indicator of cellular immunosuppression preceding the onset of CMV infection which may result in a severe outcome among pediatric lymphoma patients.

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Section: Discussionmentioning

confidence: 99%

Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection

Loutfy

Fawzy

El-Wakil

et al. 2010

Virol J

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“…Symptomatic CMV infection can occur if cellular immunity is suppressed [ 7 ]. CMV infection is therefore common in patients with AIDS.…”

Section: Discussionmentioning

confidence: 99%

Liver Abscess caused by Cytomegalovirus in a Patient with Acquired Immunodeficiency Syndrome

Lee

Park

2022

Infect Chemother

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Cytomegalovirus (CMV) causes severe infection in immunocompromised patients, especially those with acquired immunodeficiency syndrome (AIDS), those who have undergone organ transplantation, and/or those who are being treated with steroids. In patients with AIDS, CMV is the most common pathogen that causes opportunistic infections. Here, we present a case of liver abscess due to CMV in a 58-year-old man diagnosed with AIDS. At the time of the study, his CD4 T lymphocyte count was 39 cells/mm 3 , and his human immunodeficiency virus (HIV) ribonucleic acid (RNA) level was 411,000 copies/mL. Upon presentation, he complained of upper abdominal pain. Ultrasonography-guided percutaneous drainage of the liver abscess was performed, and polymerase chain reaction analysis of the drained pus was positive for CMV. He was treated with intravenous ganciclovir, after which he recovered fully. In conclusion, our patient represents, to our knowledge, the first described case of liver abscess caused by CMV in an AIDS patient, which was probably facilitated by severe immunodeficiency.

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“…It can present as fever of unknown origin, CMV retinitis, encephalitis and most commonly pneumonitis 2. CMV infection has rarely been associated with Hodgkin's or non-Hodgkin's lymphoma and there have been few reported cases of CMV infection in the gastrointestinal tract 2 3. In some instances this has been believed to have caused small bowel perforation 3–5.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus oesophagitis following treatment with fludarabine for refractory lymphoplasmacytic lymphoma

Pyatt

Mitra²

2012

BMJ Case Reports

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A 64-year-old man with a 2-week history of fatigue and fever presented to the medical admissions unit. He had a background of lymphoplasmacytic lymphoma and had recently completed a course of fludarabine-based chemotherapy. CT of the abdomen demonstrated an increase in spleen size and it was thought that his fevers were most likely due to disease recurrence or high-grade transformation. A bone marrow trephine was organised, which showed no evidence of lymphoma and positron emission tomography-CT demonstrated an area of increased avidity at the gastro-oesophageal junction. An oesophagogastroduodenoscopy was recommended, which revealed ulceration within the oesophagus and stomach. Biopsy of the lesions and immunohistochemistry confirmed a diagnosis of cytomegalovirus oesophagitis. He was treated with intravenous ganciclovir followed by oral valganciclovir for a total of 3 weeks. His fever resolved and he was discharged home approximately 8 weeks after he first presented.

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Cytomegalovirus oesophagitis in a patient with non-hodgkin's lymphoma

Cited by 4 publications

References 4 publications

Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection

Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection

Liver Abscess caused by Cytomegalovirus in a Patient with Acquired Immunodeficiency Syndrome

Cytomegalovirus oesophagitis following treatment with fludarabine for refractory lymphoplasmacytic lymphoma

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