Cytomegalovirus Pneumonia: Community-Acquired Pneumonia in Immunocompetent Hosts

Cunha, Burke A.

doi:10.1016/j.idc.2009.10.008

Cited by 47 publications

(39 citation statements)

References 27 publications

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“…Primary infection is typically asymptomatic, but may present clinically as a mononucleosis-like illness. Very occasionally, CMV seems to cause pneumonia or gastrointestinal disease in immunocompetent hosts (73).…”

Section: Infection and Diseasementioning

confidence: 99%

Cytomegalovirus: pathogen, paradigm, and puzzle

Boeckh

Geballe²

2011

J. Clin. Invest.

315

258

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Section: Infection and Diseasementioning

confidence: 99%

Cytomegalovirus: pathogen, paradigm, and puzzle

Boeckh

Geballe²

2011

J. Clin. Invest.

315

258

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“…Although the 13 H1N1 (+) patients were all lymphopenic and could facilitate CMV infection predisposition some authors claims that the temporary presence of relative lymphopenia that usually the virus H1N1 causes does not significantly alter the quality of the immune status of the patients with H1N1 acute respiratory distress syndrome [15] On the other hand Corona-Nakamura Al et al, reported that lymphopenia showed relative risk of 14.75 times for the appearance of CMV infection [16].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Pandemic Influenza a (H1N1) Virus and Cytomegalovirus Co- Existence at an Early Stage in Evangelismos Hospital-ICU Patients

Ee¹,

Asimakos²,

Grispou³

et al. 2017

J Infect Dis Ther

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Objective: Cytomegalovirus (CMV) infections in immunocompetent ICU patients have been associated with poor outcomes. We determined the distribution of cytomegalovirus coinfection among patients admitted in the ICU1 of Evangelismos Hospital of Athens with or diagnosed with pandemic influenza A (H1N1) respiratory infection. Patients:We examined retrospectively 33 ICU consequently patients with community or hospital-acquired pulmonary infection. Investigation of viral-viral coinfection rate was determined at the first 48 h after ICU admission.Results: A total of 13 patients that received a diagnosis of influenza A (H1N1) had their diagnosis confirmed by influenza A rapid antigen testing and/or by influenza A (H1N1) polymerase chain reaction (PCR). Only three out of the 13 H1N1 positive patients were cytomegalovirus bronchoalveolar lavage (BAL)-PCR positive and 10 were negative. Additionally 2 out of the 20 H1N1 negative patients were CMV-BAL-PCR positive. Conclusion:We did not find significant CMV distribution in our H1N1 positive patients at least at the early 4-5 days period after H1N1 infection. However, the study is interesting because patients with a combination of H1N1 and CMV infections have been described only rarely. The scarce presence of CMV in H1N1 patients may suggest that endogenous reactivation of CMV infection within the lungs does occur and that these patients may profit from antiviral therapy. The interplay between host and viruses is very complex and therefore the triggering for the CMV disease activation following H1N1 pneumonia is possible to require more than the absolute presents of the H1N1 virus especially in the ICU patients.

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“…In cases with immunodeficiency, CMV infection can cause pneumonia, retinitis, hepatitis, encephalitis, demyelinating polyneuropathy, myocarditis, pancreatitis, gastrointestinal diseases and adrenal diseases, and so on [13,14]. On the contrary, severe life-threatening infection induced by CMV, including CMV pneumonia, is handful in immunocompetent individuals [4][5][6]. In this paper we describe a case of CMV pneumonia, associated with BOOP in an immunocompetent host, and effectively treated with ganciclovir.…”

Section: Discussionmentioning

confidence: 99%

“…CMV pneumonia often presents as severe viral pneumonia [6], with diffuse interstitial infiltrates on chest X-ray and respiratory failure [5]. The laboratory diagnosis may be difficult, and are made serologically or pathologically.…”

Section: Discussionmentioning

confidence: 99%

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Serological Negative Cytomegalovirus Pneumonia Complicated with Bronchiolitis Obliterans Organizing Pneumonia in an Immunocompetent Patient: A Case Report

Chen¹,

Chen²,

Liu³

et al. 2016

Ann Clin Lab Res

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A 63 year-old man presented with fever, cough, sputum and tachypnea. The latter deteriorated rapidly. A thoracic computed tomography (CT) scan revealed bilateral reticular shadows appearance and quickly spread around two lungs. Notably, CMV PCR was also negative. However, based on inclusion bodies found in lung tissue transbronchial biopsy (TBLB), the diagnosis of CMV pneumonia was confirmed. Lung biopsy showed bronchiolitis obliterans organizing pneumonia (BOOP). Following ganciclovir and steroid treatment, he made a gradually recovery and was discharged seven days later. This case demonstrated that CMV pneumonia may associate with bronchiolitis obliterans organizing pneumonia in an immunocompetent patient.

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Cytomegalovirus Pneumonia: Community-Acquired Pneumonia in Immunocompetent Hosts

Cited by 47 publications

References 27 publications

Cytomegalovirus: pathogen, paradigm, and puzzle

Cytomegalovirus: pathogen, paradigm, and puzzle

Prevalence of Pandemic Influenza a (H1N1) Virus and Cytomegalovirus Co- Existence at an Early Stage in Evangelismos Hospital-ICU Patients

Serological Negative Cytomegalovirus Pneumonia Complicated with Bronchiolitis Obliterans Organizing Pneumonia in an Immunocompetent Patient: A Case Report

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