Cytomegalovirus pneumonia in immunocompetent host: Case report and literature review

Grilli, Elisabetta; Galati, Vincenzo; Bordi, Licia; Taglietti, Fabrizio; Petrosillo, Nicola

doi:10.1016/j.jcv.2012.08.010

Cited by 51 publications

(43 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ocular complications (retinitis or conjunctivitis) and gastrointestinal complications (esophageal ulcerations or proctitis), although very rare, are characteristic. The pulmonary involvement is rarely described in immunocompetent hosts [2,9,10]. …”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus acute infection with pulmonary involvement in an immunocompetent patient

Gonçalves

Cipriano

Santos

et al. 2018

IDCases

View full text Add to dashboard Cite

IntroductionCytomegalovirus (CMV) infection in healthy adults is usually asymptomatic or causes a mild mononucleosis syndrome, while severe infections are rare in immunocompetent patients and poorly documented. When described, gastrointestinal tract and the central nervous systems are the most frequent sites of severe CMV infection. Lung disease can occur, but it’s rare.Clinical caseA 29 years old man presenting with a 2-weeks history of fever, headache, malaise, dry non-productive cough and thoracic pleuritic pain, without improvement after one-week therapy with levofloxacin. Blood exams showed lymphocytosis of almost 50%, nine percent of atypical lymphocytes and elevated transaminases. Thoracic CT-scan showed bilateral infiltrate with internal air bronchogram. Blood serology showed positivity for CMV IgG and IgM, with low CMV IgG avidity. Serum and bronchoalveolar detection of CMV by polymerase chain reaction (PCR) technique was also positive. Cultures were all negative. The patient became increasingly hypoxemic and the liver transaminases worsening, the reason for which ganciclovir was started. He made a full recovery and was discharged seven days later with oral valganciclovir, completing a 3 weeks antiviral course at home.DiscussionCMV pneumonia is a rare condition, however it’s one of the three most common cause of severe viral community acquired pneumonia (CAP), along with influenza and adenovirus. CMV pneumonia should be considered in patients with atypical lymphocytes and mildly elevated serum transaminases.ConclusionIn immunocompetent hosts, even with severe CMV-CAP, the prognosis is good. However, antiviral treatment should be considered in the rare occasion of severe CMV infection. Nevertheless, more studies are needed to clarify the clinical benefit of antiviral treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus acute infection with pulmonary involvement in an immunocompetent patient

Gonçalves

Cipriano

Santos

et al. 2018

IDCases

View full text Add to dashboard Cite

show abstract

“…Tissue invasive CMV infection is rare in immunocompetent adults. 4 A systematic review of the literature of 12 studies including 409 adult-to-adult donors of a right lobe revealed donor morbidity ranging from 0% to 67%. 2 The most commonly reported postoperative events were bile leak, prolonged ileus, and minor wound problems.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Mossad¹,

Quintini²

2017

Exp Clin Transplant

View full text Add to dashboard Cite

show abstract

“…We reviewed previous reports of severe CMV infection in immunocompetent adults, usually documenting single organ or system dysfunction [2][3][4]. Among these reports, the gastrointestinal [5][6][7] and respiratory tract [8], as well as central nervous system [3], were the most frequent sites of severe CMV infection. Other manifestations included hematological disorders (hemolytic anemia and thrombocytopenia) [9,10], thrombosis of the venous or arterial vasculature [11] and ocular involvement [12].…”

Section: Discussionmentioning

confidence: 99%

Cytomegalic Infection in an Immunocompetent Patient: A Case With Multiple Organ Dysfunction

Urbano¹,

Moreira-Silva²,

Friões

et al. 2015

J Med Cases

View full text Add to dashboard Cite

Cytomegalic infection of the immunocompetent adult is usually asymptomatic or expressed by a mononucleosic syndrome. We present a case of a young adult with rare and severe primary cytomegalic infection and multisystemic involvement, namely hematological, hepatic, gastrointestinal and respiratory, including pneumonia with severe pulmonary hypertension, to the best of our knowledge, not previously described. Also of note is the fact that these dysfunctions were treated successfully with ganciclovir, although a formal indication to antivirals on cytomegalic infection of the immunocompetent patients is not established yet.

show abstract

Cytomegalovirus pneumonia in immunocompetent host: Case report and literature review

Cited by 51 publications

References 20 publications

Cytomegalovirus acute infection with pulmonary involvement in an immunocompetent patient

Cytomegalovirus acute infection with pulmonary involvement in an immunocompetent patient

Untitled

Cytomegalic Infection in an Immunocompetent Patient: A Case With Multiple Organ Dysfunction

Contact Info

Product

Resources

About