Cytomegalovirus pyloric obstruction in a child with acquired immunodeficiency syndrome

Victoria, Minerva S.; Nangia, Bhim S.; Jindrak, K

doi:10.1097/00006454-198509000-00023

Cited by 16 publications

(12 citation statements)

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“…Our review of the literature yielded a total of 25 cases with CMVassociated gastrointestinal pseudotumors, 14 of which were AIDS patients (Table 1) [6][7][8][9][10][11][12][13][14][15] and 11 non-HIV patients (Table 2), including five immunocompetent patients, 21,23,24 four patients after organ transplantation, [25][26][27][28] one patient with common variable immunodeficiency syndrome, 29 and one patient with chronic renal failure. 30 The distribution of pseudotumors in the gastrointestinal tract seems to parallel the predilection of CMV for the esophagus and right colon/ileocecal area.…”

Section: Resultsmentioning

confidence: 99%

“…Among reports of non-duodenal pseudotumor, we found only 14 cases of CMV-induced gastrointestinal pseudotumors in HIV-positive patients reported in the English literature (Table 1). [6][7][8][9][10][11][12][13][14][15] The pseudotumors were found in the esophagus, 8,12 stomach, 6,7,10,12,14 ileum, [9][10][11]15 and colon. [9][10][11]13,16 Since pseudotumors secondary to CMV often respond to medical treatment, it is important that the physicians treating severely immunocompromised patients are aware of this entity.…”

Section: Introductionmentioning

confidence: 99%

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Cytomegalovirus pseudotumor of the duodenum in a patient with AIDS: an unrecognized and potentially treatable clinical entity

Kelesidis

Tozzi

Mitty

et al. 2010

International Journal of Infectious Diseases

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CMV pseudotumor should be included in the differential diagnosis of gastrointestinal mass lesions in AIDS patients and in other immunocompromised patients. The tumor often responds to antiviral therapy, but resolution of a CMV mass as a result of oral antiviral therapy has not been previously described. Since pseudotumors secondary to CMV often respond to medical treatment, it is important that the physicians treating severely immunocompromised patients are aware of this entity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus pseudotumor of the duodenum in a patient with AIDS: an unrecognized and potentially treatable clinical entity

Kelesidis

Tozzi

Mitty

et al. 2010

International Journal of Infectious Diseases

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“…9 The first description of a CMV-associated pseudotumor was an infant with a pyloric obstruction, closely followed by an adult case with gastric antrum obstruction, both in the setting of advanced HIV infection. 10,11 Both cases were found to have an exophytic mass on endoscopy with histology demonstrating CMV inclusions with an absence of additional or alternative pathology. Reports of multifocal CMV-associated gastrointestinal pseudotumors in Macaques infected with simian immunodeficiency virus soon followe.…”

Section: Discussionmentioning

confidence: 98%

Pseudotumor presentation of CMV disease: Diagnostic dilemma and association with immunomodulating therapy

Smibert

Allison

Doerflinger

et al. 2020

Transplant Infectious Dis

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Cytomegalovirus (CMV) infection is a significant cause of morbidity in immunocompromised patients where a predictable spectrum of illness has been well described. Atypical presentations of CMV infection, including those mimicking mass lesions, otherwise known as pseudotumors, have been occasionally reported in the literature. These lesions were first seen in the context of significant immunosuppression associated with human immunodeficiency virus (HIV) but more recently, cases have been described in the non-HIV setting. Here within, the authors present two cases in patients receiving newly developed immunomodulatory therapy in the form of pembrolizumab for the management of cancer and belatacept in a kidney transplant recipient. A review of other non-HIV cases reported in the literature was also undertaken to gain a better understanding of this unusual presentation.

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“…CMV is a major herpes virus that can produce immune suppression in the neonatal period (Pass et al 1981). In addition, CMV is a common cause of opportunistic infection in immune-suppressed hosts (Macher et al 1983;Victoria et al 1985). It has been reported that in vitro lymphocyte blastogenesis responses to CMV antigens were diminished or absent in infants suffering from congenital CMV infection (Reynolds et al 1979;Starr et al 1979).…”

Section: Discussionmentioning

confidence: 99%

Replication of cytomegalovirus in human thymic epithelial cells

Numazaki

Destephano

Wong

et al. 1989

Med Microbiol Immunol

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Cytomegalovirus (CMV) has often been cited as a cause of immune suppression in children, yet little is known of the mechanisms through which this agent might affect immune function. We have succeeded in using CMV to productively infect cultured human fetal and infantile thymic epithelial (TE) cells. Morphological changes were apparent by 2-4 days after viral inoculation. CMV-related early antigen (EA) and late antigen (LA) were detected by immunofluorescence after 8 days, and progeny infectious CMV was recovered from culture media after 12-17 days. TE cells that reacted with monoclonal antibodies specific for keratin and for GQ ganglioside were predominant throughout the culture period. In contrast, infection by CMV resulted in a significant decrease in numbers of cells reactive with monoclonal antibodies specific for mesoderm-derived components. Inoculation of TE cells with CMV also caused a diminution in levels of detectable interleukin-1 (IL-1)-related antigen by 17 days after infection.

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Cytomegalovirus pyloric obstruction in a child with acquired immunodeficiency syndrome

Cited by 16 publications

References 0 publications

Cytomegalovirus pseudotumor of the duodenum in a patient with AIDS: an unrecognized and potentially treatable clinical entity

Cytomegalovirus pseudotumor of the duodenum in a patient with AIDS: an unrecognized and potentially treatable clinical entity

Pseudotumor presentation of CMV disease: Diagnostic dilemma and association with immunomodulating therapy

Replication of cytomegalovirus in human thymic epithelial cells

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