Cytomegalovirus seromismatching increases the risk of acute renal allograft rejection.

McLaughlin, Kevin; Wu, Caren; Fick, Gordon H.; Muirhead, Norman; Hollomby, David J.; Jevnikar, Anthony M.

doi:10.1097/00007890-200209270-00014

Cited by 48 publications

(29 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…and acute rejection of established allografts (1)(2)(3)(4). Experimental animal models have revealed that the exposure of hosts to viral or parasitic agents prior to transplantation can result in the development of memory T cells (5)(6)(7) that are resistant to the effects of anti-CD154 therapy (8,9).…”

Section: Linical Data Support a Correlation Between Viral Infectionsmentioning

confidence: 99%

Prevention of Allograft Tolerance by Bacterial Infection with Listeria monocytogenes

Wang¹,

Chen

Ahmed³

et al. 2008

The Journal of Immunology

101

View full text Add to dashboard Cite

Exposure to certain viruses and parasites has been shown to prevent the induction of transplantation tolerance in mice via the generation of cross-reactive memory T cell responses or the induction of bystander activation. Bacterial infections are common in the perioperative period of solid organ allograft recipients in the clinic, and correlations between bacterial infections and acute allograft rejection have been reported. However, whether bacterial infections at the time of transplantation have any effect on the generation of transplantation tolerance remains to be established. We used the Gram-positive intracellular bacterium Listeria monocytogenes (LM) as a model pathogen because its effects on immune responses are well described. Perioperative LM infection prevented cardiac and skin allograft acceptance induced by anti-CD154 and donor-specific transfusion in mice. LM-mediated rejection was not due to the generation of cross-reactive T cells and was largely independent of signaling via MyD88, an adaptor for most TLRs, IL-1, and IL-18. Instead, transplant rejection following LM infection was dependent on the expression of the phagosome-lysing pore former listeriolysin O and on type I IFN receptor signaling. Our results indicate that bacterial exposure at the time of transplantation can antagonize tolerogenic regimens by enhancing alloantigen-specific immune responses independently of the generation of cross-reactive memory T cells.

show abstract

Section: Linical Data Support a Correlation Between Viral Infectionsmentioning

confidence: 99%

Prevention of Allograft Tolerance by Bacterial Infection with Listeria monocytogenes

Wang¹,

Chen

Ahmed³

et al. 2008

The Journal of Immunology

101

View full text Add to dashboard Cite

show abstract

“…Furthermore, most studies have indicated that successful antiviral prophylaxis has a beneficial effect on long-term graft function (8). This suggests that viral replication is a component of risk, but the precise mechanisms underlying this effect are debated (9,11,(26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Introductionmentioning

confidence: 99%

The Cell Biology of Cytomegalovirus: Implications for Transplantation

Kaminski

Fishman

2016

American Journal of Transplantation

View full text Add to dashboard Cite

Interpretation of clinical data regarding the impact of cytomegalovirus (CMV) infection on allograft function is complicated by the diversity of viral strains and substantial variability of cellular receptors and viral gene expression in different tissues. Variation also exists in nonspecific (monocytes and dendritic cells) and specific (NK cells, antibodies) responses that augment T cell antiviral activities. Innate immune signaling pathways and expanded pools of memory NK cells and cd T cells also serve to amplify host responses to infection. The clinical impact of specific memory T cell anti-CMV responses that cross-react with graft antigens and alloantigens is uncertain but appears to contribute to graft injury and to the abrogation of allograft tolerance. These responses are modified by diverse immunosuppressive regimens and by underlying host immune deficits. The impact of CMV infection on the transplant recipient reflects cellular changes and corresponding host responses, the convergence of which has been termed the "indirect effects" of CMV infection. Future studies will clarify interactions between CMV infection and allograft injury and will guide interventions that may enhance clinical outcomes in transplantation.

show abstract

“…Although CMV prophylaxis can reduce the risk of CMV disease and associated mortality, its effects on allograft loss and acute transplant rejection have not been clearly established [12]. Many reports have demonstrated that CMV serostatus-that is, "seropositive or seronegative," as defined by conventional classifications-influences clinical outcome in renal transplantation [7,8]. For example, the combination of CMV-seronegative transplant recipients (RϪ) with CMVseropositive transplant donors (D+) led to the highest risk of CMV disease.…”

mentioning

confidence: 99%

Association of the Outcome of Renal Transplantation with Antibody Response to Cytomegalovirus Strain--Specific Glycoprotein H Epitopes

Ishibashi

Tokumoto

Tanabe

et al. 2007

Clinical Infectious Diseases

View full text Add to dashboard Cite

Background. Cytomegalovirus (CMV) is the most important pathogen affecting the outcome of renal transplantation. The combination of CMV-seronegative transplant recipients with CMV-seropositive transplant donors places recipients at the highest risk of CMV disease. In cases of congenital CMV infection, existing immunity only partially protected mothers from reinfection with a different genotypic strain. The effect of differences in infected CMV strains between CMV-seropositive transplant donors and CMV seropositive transplant recipients on the outcome of transplantation remains unclear.Methods. In this prospective multicenter study, the presence of antibodies against strain-specific glycoprotein H epitopes in 84 CMV-seropositive transplant donor/CMV-seropositive transplant recipient renal transplantation cases were determined, and their relationships to acute transplant rejection, CMV infection, degree of antigenemia, and CMV disease were evaluated.Results. Among the 84 donor/recipient pairs, 45 and 32 had matched and mismatched strain-specific glycoprotein H antibodies, respectively. Acute transplant rejection in the mismatched group was more frequent than it was in the matched group (63% vs. 22%;). CMV disease was also more frequently observed in the P p .005 mismatched group (28% vs. 9%;). The mismatched group had a higher level of antigenemia ( P p .026 P p ). .019Conclusions. Our results illustrate more adverse events in the cases with a CMV-seropositive transplant donor and a CMV-seropositive transplant recipient in which the glycoprotein H antibodies are mismatched, suggesting that reinfection with a different CMV strain results in more complications.

show abstract

Cytomegalovirus seromismatching increases the risk of acute renal allograft rejection.

Abstract: Patients who are CMV seromismatched are at higher risk of acute renal allograft rejection. This finding suggests that CMV infection or disease is a risk factor for acute rejection.

Cited by 48 publications

References 18 publications

Prevention of Allograft Tolerance by Bacterial Infection with Listeria monocytogenes

Prevention of Allograft Tolerance by Bacterial Infection with Listeria monocytogenes

The Cell Biology of Cytomegalovirus: Implications for Transplantation

Association of the Outcome of Renal Transplantation with Antibody Response to Cytomegalovirus Strain--Specific Glycoprotein H Epitopes

Contact Info

Product

Resources

About