Cytomegalovirus seropositivity is associated with herpes zoster

Ogunjimi, Benson; Hens, Niel; Pebody, Richard; Jansens, Hilde; Seale, Holly; Quinlivan, Mark; Theeten, Heidi; Goossens, Herman; Breuer, Judith; Beutels, Philippe

doi:10.1080/21645515.2015.1037999

Cited by 13 publications

(6 citation statements)

References 29 publications

(33 reference statements)

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“…Together, our observations can be explained by a more activated and responsive immune system in CMV-seropositive adults. However, this does not align with our recent observation that CMV seropositivity is associated with an increased risk of HZ in adults younger than 50 years 24 . One alternative hypothesis could be that a chronic CMV infection, shown to have led to more differentiated and possibly less equipped T-cell immunity against various pathogens including VZV 25 , has weakened the immune barriers against VZV and thereby has led to a more pronounced in vivo spreading of VZV (and subsequent boosting).…”

Section: Discussioncontrasting

confidence: 97%

Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Ogunjimi

Bergh

Meysman

et al. 2017

Sci Rep

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Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in re-exposed grandparents compared to control participants up to 9 months after re-exposure. Using a longitudinal mixture modelling approach, we found that 25% and 17% of re-exposed grandparents showed a boosting of VZV-specific CD4+ IL-2-producing T-cells and VZV-specific antibodies, respectively. The antibody boosting occurred exclusively in cytomegalovirus (CMV) IgG-positive participants. CMV IgG-positive participants also had higher VZV IE62-specific CD4+ IFN-γ-producing T-cell percentages and VZV-specific antibody titres. The protective effect of re-exposure to chickenpox is likely limited, as boosting only occurred in 17–25% of the VZV re-exposed grandparents and for less than one year.

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Section: Discussioncontrasting

confidence: 97%

Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Ogunjimi

Bergh

Meysman

et al. 2017

Sci Rep

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“…CMV latency is recognized increasingly as a significant factor for accelerated T cell ageing , and as such may add to the increased risk for infections as well as cardiovascular disease in healthy elderly people. In elderly ESRD patients, the risk of cardiovascular disease events and death or infections is even more increased.…”

Section: Discussionmentioning

confidence: 99%

Latency for cytomegalovirus impacts T cell ageing significantly in elderly end-stage renal disease patients

Huang¹,

Langerak

Baan³

et al. 2016

Clinical and Experimental Immunology

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The number of elderly patients with end-stage renal disease (ESRD) has increased significantly during the last decade. Elderly ESRD patients are vulnerable to infectious complications because of an aged immune system. Additional immunological ageing effects may be derived from the uraemic environment and cytomegalovirus (CMV) latency. Elderly patients may be affected by these factors in particular, but data in this age group are limited. To assess the degree of immunological ageing and proliferative capacity of T lymphocytes, 49 elderly ESRD patients (defined as aged ≥ 65 years) on the renal transplantation waiting list were recruited and compared to 44 elderly healthy individuals (HI), matched for age and CMV serostatus. CMV latency was associated with more highly differentiated CD4 and CD8 T cells in both elderly HI and patients. Elderly CMV seropositive ESRD patients showed a substantial reduction in the number of naive CD4 and CD8 T cells compared with age- and CMV serostatus-matched HI. Elderly ESRD patients also showed significantly decreased numbers of central memory CD4 and CD8 T cells compared with HI, independently of CMV serostatus. In addition, thymic output and relative telomere length of both CD4 and CD8 T cells were decreased in CMV seropositive ESRD patients compared with HI. The proliferative capacity of T cells was similar for patients and HI. Elderly ESRD patients have an advanced aged T cell compartment when compared to age-matched healthy controls, which is driven mainly by CMV latency.

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“…Based on previous findings, we hypothesized that NK cells might serve as an immunological mediator between psychological stress and HZ pathogenesis. Psychological stress can induce reactivation and shedding of cytomegalovirus (CMV) [ 12 ], and CMV infection might be a trigger for VZV reactivation in young adults [ 13 ]. Because CMV-specific immunity may be an important variable in HZ pathogenesis and a surrogate marker of overall T cell immunity, we also compared CMV-specific CMI between patients with HZ and control subjects.…”

Section: Introductionmentioning

confidence: 99%

Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster

Kim¹,

Choi²,

Bae³

et al. 2018

PLoS ONE

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The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little is known about the interplay between natural killer cells and psychological stress in the pathogenesis of herpes zoster. This study aimed to investigate possible associations among natural killer cells, T cells and psychological stress in herpes zoster. Interferon-gamma secretion from natural killer cell, psychological stress events, stress cognition scale scores and cytomegalovirus-specific cell-mediated immunity were compared between 44 patients with herpes zoster and 44 age- and gender-matched control subjects. A significantly lower median level of interferon-gamma secreted by natural killer cells was observed in patients with a recent diagnosis of herpes zoster than in control subjects (582.7 pg/ml vs. 1783 pg/ml; P = 0.004), whereas cytomegalovirus-specific cell-mediated immunity was not associated with herpes zoster. Psychological stress events and high stress cognition scale scores were significantly associated in patients with herpes zoster (P<0.001 and P = 0.037, respectively). However, reduced interferon-gamma secretion from natural killer cell and psychological stress were not associated. In conclusion, patients with a recent diagnosis of herpes zoster display reduced interferon-gamma secretion from natural killer cells and frequent previous psychological stress events compared with controls. However, reduced natural killer cell activity is not an immunological mediator between psychological stress and herpes zoster.

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Cytomegalovirus seropositivity is associated with herpes zoster

Cited by 13 publications

References 29 publications

Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Latency for cytomegalovirus impacts T cell ageing significantly in elderly end-stage renal disease patients

Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster

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