Cytomegalovirus seroprevalence in pregnant women in the western region of Romania: A large‑scale study

Gorun, Florin; Motoi, Sorin; Malița, Daniel; Navolan, Dan; Nemescu, Dragoş; Olariu, Tudor Rareș; Craina, Marius; Vilibić-Čavlek, Tatjana; Ciohat, Ioana; Boda, Daniel; Dobrescu, Amadeus

doi:10.3892/etm.2020.8945

Cited by 24 publications

(49 citation statements)

References 19 publications

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“…This study is part of a larger project that demonstrated a decrease in the seroprevalence of Toxoplasma gondii , CMV and rubella virus, among women of reproductive age and pregnant women in western Romania over a decade from 2008 to 2018 [ 11 , 12 , 13 ]. Thus, our previous research showed a decrease in seroprevalence among women of reproductive age, between 2008–2010 and 2015–2018, from 43.8% to 38.8% [ 11 ], in the case of Toxoplasma gondii .…”

Section: Discussionmentioning

confidence: 99%

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Simultaneous Seroprevalence to Toxoplasma gondii, Cytomegalovirus and Rubella Virus in Childbearing Women from Western Romania

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Background and Objectives: Toxoplasma gondii, cytomegalovirus (CMV) and rubella virus, besides other agents, belong to a group named the TORCH complex. Research on the epidemiology of these agents in women is of particular interest, as primary infection during pregnancy could cause severe damage to the fetus. Women who had contracted infection before pregnancy develop IgG antibodies, so the fetus is protected in case of contact with the same agent. Our scope was to identify the childbearing women simultaneously protected or susceptible to a primary infection to two or three agents mentioned above. Materials and Methods: A cross-sectional study was performed on 6961 fertile Caucasian women from Western Romania, to analyze the simultaneous seroprevalence to two or three of the pathogens from the TORCH complex: Toxoplasma gondii, CMV, and rubella virus. Sampling was conducted at two time points: 2008–2010 (group 1; 1461 participants) and 2015–2018 (group 2; 5500 participants). Results: The percentage of women simultaneously seropositive to IgG-anti-Toxoplasma gondii/IgG-anti-CMV, IgG-anti-Toxoplasma gondii/IgG-anti-rubella, IgG-anti-CMV/IgG-anti-rubella or IgG-anti-Toxoplasma gondii and IgG-anti-CMV/IgG-anti-rubella antibodies decreased between the two groups (2008–2010 vs. 2015–2018): 41.4% vs. 36.1%, OR = 0.79, p = 0.0002; 41.8% vs. 35.7%, OR = 0.77, p < 0.0001; 88.9% vs. 83.6%, OR = 0.63, p < 0.0001; 39.6% vs. 33.2%, OR = 0.75, p < 0.0001. When comparing women from urban and rural areas, the simultaneous seroprevalence was higher in rural areas. In women tested 2008–2010 (group 1) the simultaneous seroprevalence (urban vs. rural) was: 38.4% vs. 49.1%, OR = 1.54, p = 0.0002; 38.4% vs. 50.6%, OR = 1.64, p < 0.0001; 88.8% vs. 89.2%, OR = 1.04, NS; 36.4% vs. 47.7%, OR = 1.58, p = 0.0001. A similar trend was found in women tested in group 2. Conclusions: The rate of simultaneous seropositivity to Toxoplasma gondii, CMV and rubella virus among Romanian women of reproductive age decreased significantly between 2008–2010 and 2015–2018 and the susceptibility to infections increased. It is necessary to apply increased prevention measures among susceptible pregnant women.

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Section: Discussionmentioning

confidence: 99%

“…[ 11 ]. In the western region of Romania, our previous research showed also a decrease in CMV seroprevalence among women of reproductive age, from 94% to 91.8% [ 12 ]. An increased seroprevalence was found in women from rural compared to urban areas.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Seroprevalence to Toxoplasma gondii, Cytomegalovirus and Rubella Virus in Childbearing Women from Western Romania

et al. 2021

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“…This is the largest study on the seroprevalence of TORCH infections among women of reproductive age in Romania [ 11 , 12 ]. The presented results show that the rubella seronegative rate among women of reproductive age in the western region of Romania increased between 2008–2010 and 2015–2018 from 5.9% to 8.6%, above the European average of 7.6% [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Rubella Antibodies among Fertile Women in the West of Romania, 18 Years after the Implementation of Immunization

Gorun

Malița

Ciohat³

et al. 2021

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Seronegative women are susceptible to primary rubella virus (RV) infection during pregnancy, which can cause fetal damage. Vaccination represents the main strategy in rubella prevention. The aim of this study was to analyze changes in the rubella seroprevalence and identify populations with a high susceptibility to RV. A cross-sectional study was performed on 6914 Caucasian fertile women who had Toxoplasma gondii, other viruses, Rubella, Cytomegalovirus, and the herpes simplex virus (TORCH) screening in two distinct periods—1452 at the Timișoara Municipal Hospital, Romania (Group 1: 2008–2010) and 5462 at the laboratory Bioclinica S.A., Timișoara, Romania (Group 2: 2015–2018). The RV seroprevalence decreased (Group 1 versus Group 2; 94.1% (92.7–95.2) versus 91.4% (90.6–92.1), OR = 0.76 (p = 0.0007)). According to the year of birth and eligibility to vaccination program, RV seroprevalence rates were 82.4% (76.8–86.8)/1997–2004, 85.4% (80.5–89.3)/1995–1996, 90.1% (89.0–91.1)/<1989, and 95.8% (94.7–96.6)/1989–1994. No significant difference in the RV seropositivity according to the place of residence was found. The overall RV susceptibility increased from 2008–2010 to 2015–2018. The highest susceptibility was found in women born between 1997–2004 eligible for measles-mumps-rubella (MMR) vaccine through the family practice system and the lowest in women born between 1989–1994 eligible for monovalent rubella vaccine conducted in schools.

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“…The review by Tanasa et al (1) entitled 'Anosmia and ageusia associated with coronavirus infection (COVID- 19)what is known?' summarizes the existing data regarding the association of anosmia and ageusia with the SARS-CoV-2 infection.…”

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confidence: 99%

“…In their study entitled 'Cytomegalovirus seroprevalence in pregnant women in the western region of Romania: A largescale study', Gorun et al (19) analyzed the CMV seroprevalence according to demographic features of pregnant women in western Romania, as well as the evolution of CMV immunity in two time intervals. The seroprevalence was higher in women from rural areas compared to those from urban areas.…”

mentioning

confidence: 99%

Cytomegalovirus seroprevalence in pregnant women in the western region of Romania: A large‑scale study

Cited by 24 publications

References 19 publications

Simultaneous Seroprevalence to Toxoplasma gondii, Cytomegalovirus and Rubella Virus in Childbearing Women from Western Romania

Simultaneous Seroprevalence to Toxoplasma gondii, Cytomegalovirus and Rubella Virus in Childbearing Women from Western Romania

Prevalence of Rubella Antibodies among Fertile Women in the West of Romania, 18 Years after the Implementation of Immunization

[Editorial] 2nd Special Issue: Tackling key immunological and immuno-dermatological pathways and their link to treatment options

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