Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation

Wang, Huiru; Liu, Huilan; Zhou, Li; Wang, Dongyao; Wang, Shushu; Liu, Qian; Wu, Yun; Tu, Meijuan; Sun, Zimin; Zheng, Xiaohu; Fu, Binqing; Wang, Baolong; Wei, Haiming

doi:10.1016/j.isci.2022.105065

iScience

2022

DOI: 10.1016/j.isci.2022.105065

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Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation

Huiru Wang

Huilan Liu

Li Zhou

et al.

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2024

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Functional Fc receptors are crucial in antibody‐mediated protection against cytomegalovirus

Bootz,

Reuter,

Nimmerjahn

et al. 2024

Eur J Immunol

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Human cytomegalovirus is a medically important pathogen. Previously, using murine CMV (MCMV), we provided evidence that both neutralizing and nonneutralizing antibodies can confer protection from viral infection in vivo. In this study, we report that serum derived from infected animals had a greater protective capacity in MCMV‐infected RAG−/− mice than serum from animals immunized with purified virus. The protective activity of immune serum was strictly dependent on functional Fcγ receptors (FcγR). Deletion of individual FcγRs or combined deletion of FcγRI and FcγRIV had little impact on the protection afforded by serum. Adoptive transfer of CD115‐positive cells from noninfected donors demonstrated that monocytes represent important cellular mediators of the protective activity provided by immune serum. Our studies suggest that Fc–FcγR interactions and monocytic cells are critical for antibody‐mediated protection against MCMV infection in vivo. These findings may provide new avenues for the development of novel strategies for more effective CMV vaccines or antiviral immunotherapies.

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Functional Fc receptors are crucial in antibody‐mediated protection against cytomegalovirus

Bootz,

Reuter,

Nimmerjahn

et al. 2024

Eur J Immunol

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show abstract

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Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation

Cited by 1 publication

References 56 publications

Functional Fc receptors are crucial in antibody‐mediated protection against cytomegalovirus

Functional Fc receptors are crucial in antibody‐mediated protection against cytomegalovirus

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