Cytomorphological Aspects of Hashimoto's Thyroiditis: Our Experience at a Tertiary Center

Rathi, Monika; Ahmad, Faiyaz; Budania, Satish Kumar; Awasthi, Seema; Kumar, Ashutosh; Dutta, Shyamoli

doi:10.4137/cpath.s13580

Cited by 19 publications

(20 citation statements)

References 14 publications

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“…Fire flares were noted in few patients of HT ( n = 3). Similar frequency was noted by Rathi et al [ 29 ]. In contrast, some studies noted slightly more frequency [ 26 , 35 ].…”

Section: Discussionsupporting

confidence: 90%

Cytomorphological Spectrum of Thyroiditis: A Review of 110 Cases

Chandanwale

Nair

Gambhir

et al. 2018

Journal of Thyroid Research

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Introduction Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality. Aim Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Materials and Methods The study included consecutive 110 cases of thyroiditis. Detailed cytomorphological features were studied and correlated with ultrasonography findings, thyroid function test, anti-thyroid peroxidase antibodies (anti-TPO) and histopathological features where thyroidectomy specimens were received for histopathological examination. Results The majority were Hashimoto's thyroiditis (n = 100) and females (n = 103). Other forms of thyroiditis were Hashimoto's thyroiditis with colloid goiter (n = 5), De Quervain's thyroiditis (n = 3), and one case each of postpartum thyroiditis and Hashimoto's thyroiditis with associated malignancy. The majority of patients were in the age group of 21–40 (n = 70) and the majority (n = 73) had diffuse enlargement of thyroid. The majority of patients were hypothyroid (n = 52). The serum anti-TPO antibodies were elevated in 47 patients out of 71 patients. In the 48 patients who underwent ultrasonography, 38 were diagnosed as having thyroiditis. The most consistent cytomorphological features seen in fine-needle aspiration smears of Hashimoto's thyroiditis were increased background lymphocytes, lymphocytic infiltration of thyroid follicular cell clusters, and Hurthle cells. Conclusion The diagnostic cytological features in Hashimoto's thyroiditis are increased background lymphocytes, lymphocytic infiltration of thyroid follicular cell clusters, and Hurthle cells. FNAC remains the “Gold Standard” for diagnosing Hashimoto's thyroiditis. Clinical history, thyroid function, and biochemical parameters are the key for diagnosis of other forms of thyroiditis.

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“…Fire flares were noted in few patients of HT ( n = 3). Similar frequency was noted by Rathi et al [ 29 ]. In contrast, some studies noted slightly more frequency [ 26 , 35 ].…”

Section: Discussionsupporting

confidence: 90%

Cytomorphological Spectrum of Thyroiditis: A Review of 110 Cases

Chandanwale

Nair

Gambhir

et al. 2018

Journal of Thyroid Research

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“…Monika Rathi et al and Friedman M et al also reported markedly high percentage of cases showing Hurthle cell change. 14,15 Data in this study on follicular atypia 26.66% and follicular cell infilteration by lymphocytes 82.66% were comparable with the study of Jayaram et al 16 CONCLUSION: FNAC is a safe, reliable, cost effective and time saving method in the diagnosis of thyroiditis. Being a benign condition also reduce the rate of unnecessary operation, which can be treated conservatively.…”

Section: Introductionsupporting

confidence: 76%

Cytomorphological and Biochemical Correlation in Thyroiditis

Krishna¹,

Manju²

2015

jemds

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Hashimoto's thyroiditis is an autoimmune chronic inflammatory disease of the thyroid gland. It is the second most common thyroid lesion diagnosed by cytology, after goiter. MATERIAL AND METHOD: The Study was conducted in the department of pathology. All aspiration were done by cytopathologists to ensure representative sampling.Using sterile precautions FNAC was performed using nonaspiration or aspiration techniques by 23 G needle with 10 ml syringe. The smears were either air dried or alcohol fixed (95%). Air dried smears were stained by the Gimsa stain and alcohol fixed by Hematoxiline and eosin. RESULT: We included 75 cases of thyroiditis. 4 cases were male and 71 were female with female to male ratio of 17.75:1. The age ranged from 8 to 65years with a median age of 36.5 years. 75 csaes of thyroiditis have been evaluated on the basis of cytomorphological criteria, Biochemical and clinical findings of patients. CONCLUSION: FNAC is a safe, reliable, cost effective and time saving method in the diagnosis of thyroiditis.

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“…About little more than 12% of the subjects were found to be euthyroid (Rathi M et al). 23 The cytological compensatory changes that was suggestive of hypothyroid state. Fluoride that is absorbed in to the blood is found in higher concentration in the plasma than the cells around.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphological alterations of thyroid gland consequent upon fluorosis

et al. 2019

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Background: Study aimed at assessing the impact of elevated fluoride from drinking water on thyroid gland structure and function in fluorosis prone areas. Iodine is incorporated in the thyroid synthesis by thyroid gland but in the presence of low Iodine levels fluoride is likely to interfere with the concentrating capacity of thyroid of iodine in thyroid production, consequently reflecting changes in thyroid parameters and also cytomorphological features manifesting hypothyroidism in association with different pathological entities.Methods: Prakasam district in Andhra Pradesh is fluorosis prone zone and subjects are picked up from highly vulnerable zone in this district and their specimens are collected to study cytomorphological changes of the thyroid gland and biochemical parameters of blood samples for thyroid function test were considered. Cytological study by way of Fine Needle Aspiration Cytology (FNAC) of thyroid gland, biochemical parameters pertaining to function of thyroid gland namely Free triiodothyronine (FT3), Free Thyroxine (FT4) and Thyroid stimulating hormone (TSH) were assessed in the subjects from fluorosis prone zone.Results: The results were statistically significant with concurrent association of different cytological alterations of thyroid gland in these subjects like Hashimoto’s thyroiditis of hypothyroidism, adenomatous goitre, colloid goitre and few of follicular adenoma/neoplasm. FNAC makes cytological changes evident showing different morphological features that comprise different pathological entities largely with an evidence of hypothyroidism in most of the cases in the given study.Conclusions: The results of the study strongly suggest assessing the magnitude of the problem of fluorosis and also magnitude of its influence on thyroid structure and function that warrants assessment of the thyroid function by biochemical and cytological studies.

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Cytomorphological Aspects of Hashimoto's Thyroiditis: Our Experience at a Tertiary Center

Cited by 19 publications

References 14 publications

Cytomorphological Spectrum of Thyroiditis: A Review of 110 Cases

Cytomorphological Spectrum of Thyroiditis: A Review of 110 Cases

Cytomorphological and Biochemical Correlation in Thyroiditis

Cytomorphological alterations of thyroid gland consequent upon fluorosis

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