Cytomorphological Study of Thyroid Lesions Using the Bethesda System for Reporting Thyroid Cytology and Its Correlation with Thyroid Function Test

Thakor, Trusha; Daveshwar, Meena; Shah, H. S.

doi:10.14260/jemds/2020/204

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…Patel et al [18], which reported a male-to-female ratio of 1:4.8. Observed ratios in the present study are in concordance with those reported by T. Thakor et al [15] and V. Jain et al [9], highlighting the recurrent theme of thyroid lesions exhibiting a higher prevalence among females.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, female dominance remained a consistent pattern, with 88% females and 12% males, illustrating a striking female-to-male ratio of 7.3:1. This gender disproportionality resonates with the findings of earlier studies by V. Jain et al [9] and T. Thakor et al [15], as well as the study conducted by C.B. Patel et al [18], which reported a male-to-female ratio of 1:4.8.…”

Section: Discussionsupporting

confidence: 92%

“…Comparative insights from V. Jain et al [9] emphasised a similar trend, with a focal point in the 31-40 age bracket, where the average age of the population was 41.3 ± 12.4 years. In contrast, T. Thakor et al [15] determined the predominance in the 41-50 age group, with an average age of 39.64 years.…”

Section: Discussionmentioning

confidence: 93%

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Cytological study of different thyroid lesions and its correlation with thyroid function test

Yadav,

Mitra,

Rai

2023

ijmmr

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The research relevance of the combined use of fine needle aspiration cytology, sonography, and thyroid function tests is determined by accurate diagnostics of thyroid enlargement in both adults and children. The study aimed to analyse thyroid lesions through cytological analysis and their correlation with thyroid function test results. This cross-sectional study enrolled 100 patients with suspected thyroid disorders and nodules. Comprehensive assessments included clinic demographics, fine needle aspiration cytology procedures, and thyroid hormone profiles. Based on the Bethesda system, cytological diagnoses were correlated with thyroid function test results using the chemiluminescent microparticle immunoassay method. Non-tumour thyroid lesions were found to be the most common (95%), with colloidal goitre being the most common. Neoplastic cases mainly included papillary and follicular carcinoma. Most thyroid lesions occurred among the 21-30 age group, non-neoplastic cases were more frequent among the 10-20 age group, and neoplastic cases were more common in those aged 21-40. All patients had neck swelling. Most cases were euthyroid (76%), predominantly classified as Category 2. A strong correlation between cytological diagnoses and thyroid hormone levels (p=0.04) was observed. Fine needle aspiration cytology demonstrated good sensitivity (80%) and high specificity (98.46%), with an 80% positive predictive value and 98.46% negative predictive value, resulting in a diagnostic accuracy of 97.14%. The study highlights the valuable role of fine needle aspiration cytology, when coupled with thyroid function tests, in effectively guiding the management of patients with thyroid lesions, owing to its impressive accuracy, sensitivity, and specificity

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

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Cytological study of different thyroid lesions and its correlation with thyroid function test

Yadav,

Mitra,

Rai

2023

ijmmr

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“…Majority of patients in the present study were euthyroid (54, 90%) and most of those with altered thyroid profile belonged to benign category, similar to the observations of Thakor et al 13 Majority of the cases (36) showed hypo-echogenicity on ultrasonography and a significant proportion (20) belonged to Bethesda criteria V and VI (malignant cases), a finding similar to the study by Maia F et al 14 With respect to the distribution of cases in cytology according to Bethesda classification, maximum cases (21) were noted from category IV which is follicular neoplasm or suspicious for follicular neoplasm. Previous similar studies by Mondal et al, Alshaikh et al and Dhamecha M.P et al have had maximum number of cases belonging to category II followed by category IV.…”

Section: Discussionsupporting

confidence: 91%

Study of nuclear morphometry in the cytologic evaluation of thyroid neoplasms

Thomas,

Chhadi,

Chhadi

2023

J Pathol Nep

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Background: Nuclear morphometry is purported to allow better differentiation between various thyroid lesions beyond what is offered by conventional cytology. The present study was conducted to evaluate the nuclear morphometric parameters in fine needle aspirates of thyroid neoplasms and to study their role in differentiating benign and malignant thyroid neoplasms. Materials and Methods: Nuclear morphometric parameters of all the patients presenting with thyroid swelling and undergoing fine needle aspiration cytology (FNAC) and belonging to Category III, IV, V, and VI of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) were studied. Results: Out of a total of 60 cases, a maximum was noted from category IV which is follicular neoplasm or suspicious for follicular neoplasm. The sensitivity of FNAC for the diagnosis of thyroid lesions in the present study was observed at 87.71%. The nuclear morphometry parameters – short axis diameter, long axis diameter, nuclear area, and perimeter showed significant differences between benign and malignant lesions (p-value <0.001). The mentioned nuclear morphometric parameters were observed to be the highest in anaplastic carcinoma followed by papillary carcinoma and medullary carcinoma, and lowest in follicular neoplasms. A significant difference was observed in the nuclear parameters of follicular adenoma and follicular carcinoma. Conclusions: Nuclear morphometry can help in distinguishing between benign and malignant thyroid lesions, particularly in the diagnosis of indeterminate smears where there is a disparity in diagnosis on conventional cytology, especially in differentiating follicular neoplasms.

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“…An important observation in our study is that relatively higher frequency of the autoimmune thyroiditis (33.66%; 102/303) in comparison to other studies [16][17][18]. A similar trend of a higher proportion of autoimmune thyroiditis was described by a recent study carried out in a neighbouring state [19].…”

Section: Discussionsupporting

confidence: 87%

Evaluation of Cyto-Morphological Profile of Thyroid Swellings Using Bethesda System for Reporting and its Correlation with Biochemical Parameters in Cases of Autoimmune Thyroiditis: A Sub-Himalayan Tertiary Care Experience

Bodh¹,

Thakur²,

Kumar³

et al. 2023

Act Scie Canbio

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Background: Thyroid disorders are among the commonest endocrine disorders worldwide, including India. FNAC (fine needle aspiration cytology) is used for thyroid swelling as the initial diagnostic test due to its superior diagnostic reliability and costeffectiveness. Thyroid antibody levels and thyroid function test are among the many other initial tests available for thyroid lesions.Objective: To study the cytomorphological profile of thyroid swelling using the Bethesda system for reporting thyroid cytopathology in a sub-Himalayan tertiary care centre, and assess correlation of biochemical parameters in cytologically diagnosed cases of autoimmune thryoiditis. Materials and Methods:In this retrospective study, departmental records of FNAC performed for thyroid swelling between March 2018 and February 2021 were retrieved and analysed. The Bethesda system was used for reporting of cytology. Biochemical parameters such as antithyroid peroxidase antibody (Anti-TPO) and thyroid stimulating hormone (TSH) of autoimmune thyroiditis were assessed to find out their association with the cytopathology.Results: A total of 303 FNAC of palpable thyroid swelling were included in the present study. 9 (2.97%) cases were nondiagnostic-Bethesda category I, 256 (84.49%) were diagnosed as benign-category II, 4 (1.32%) atypia of undetermined significance or follicular lesion of undetermined significance (AUS/AFLUS)-category III, 10 (3.30%) as follicular neoplasm or suspicious for follicular neoplasm (FN/SFN)-category IV, 2 (0.66%) suspicious for malignancy (SM)-category V and 22 were malignant-category VI. Among the benign cases (category II), the final diagnosis was colloid goitre in 143 (47.19%) and autoimmune thyroiditis in 102 (33.66%). Out of 102 autoimmune thyroiditis cases, biochemical reports (Anti-TPO and TSH) were available in 85 patients. Anti-TPO was raised in 74 out of 85 cases (87.06%). Sixty three of 85 (74.11%) cases were euthyroid, 18 (21.18%) hypothyroid and 04 (4.71%) hyperthyroid. In category VI, papillary carcinoma and anaplastic carcinoma was seen in 20 (6.60%) and 2 (0.66%) cases respectively. Conclusion:Colloid goitre followed by autoimmune thyroiditis, were the most common lesions on evaluating thyroid swelling.Relatively autoimmune thyroiditis was more prevalent in our region.

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Cytomorphological Study of Thyroid Lesions Using the Bethesda System for Reporting Thyroid Cytology and Its Correlation with Thyroid Function Test

Cited by 4 publications

References 8 publications

Cytological study of different thyroid lesions and its correlation with thyroid function test

Cytological study of different thyroid lesions and its correlation with thyroid function test

Study of nuclear morphometry in the cytologic evaluation of thyroid neoplasms

Evaluation of Cyto-Morphological Profile of Thyroid Swellings Using Bethesda System for Reporting and its Correlation with Biochemical Parameters in Cases of Autoimmune Thyroiditis: A Sub-Himalayan Tertiary Care Experience

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