Cytopathie mitochondriale : une cause inhabituelle d’atrophie villositaire totale chez le nourrisson

Bonnemains, C.; Berthelot, Jacques; Camaret, Bénédicte Mousson de; Chomienne, F.; Duveau, Estelle; Giniès, J.-L.

doi:10.1016/j.arcped.2003.10.012

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Perturbed enterocyte mitochondrial function is believed to initiate inflammation and relapses in inflammatory bowel disease, potentially through disrupting the balance between the enterocyte and the endogenous enteric microbiome ( 92 ) or by disrupting the active transport of luminal substrates or ion flux across the cell membrane. Disruption of mitochondrial function may be responsible for a wide range of disorders involved in enterocyte dysfunction, including (a) enterocyte dysfunction following traumatic brain injury ( 93 , 94 ); (b) small bowel injury related to non-steroidal anti-inflammatory drug exposure ( 95 – 97 ), surgical manipulation ( 98 , 99 ), intestinal allergic reaction ( 100 ), and carnitine deficiency ( 101 ); (c) cyclooxygenase inhibitor-induced enteropathy ( 102 ); (d) small bowel dysfunction in chronic alcoholics with liver disease ( 103 ), and rodent models of cirrhosis ( 104 ) and obstructive jaundice ( 105 ); (e) Clostridium perfringens enterotoxin-mediated enterocyte cell death ( 106 , 107 ); (f) Clostridium difficile toxin A ( 108 ); (g) methotrexate-induced enteritis ( 109 ); and finally, (h) cases of villous atrophy ( 110 , 111 ).…”

Section: Mitochondrial Disease Is Associated With Gi Disordersmentioning

confidence: 99%

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome

Frye

Rose

Slattery

et al. 2015

Microbial Ecology in Health & Disease

113

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Autism spectrum disorder (ASD) affects a significant number of individuals worldwide with the prevalence continuing to grow. It is becoming clear that a large subgroup of individuals with ASD demonstrate abnormalities in mitochondrial function as well as gastrointestinal (GI) symptoms. Interestingly, GI disturbances are common in individuals with mitochondrial disorders and have been reported to be highly prevalent in individuals with co-occurring ASD and mitochondrial disease. The majority of individuals with ASD and mitochondrial disorders do not manifest a primary genetic mutation, raising the possibility that their mitochondrial disorder is acquired or, at least, results from a combination of genetic susceptibility interacting with a wide range of environmental triggers. Mitochondria are very sensitive to both endogenous and exogenous environmental stressors such as toxicants, iatrogenic medications, immune activation, and metabolic disturbances. Many of these same environmental stressors have been associated with ASD, suggesting that the mitochondria could be the biological link between environmental stressors and neurometabolic abnormalities associated with ASD. This paper reviews the possible links between GI abnormalities, mitochondria, and ASD. First, we review the link between GI symptoms and abnormalities in mitochondrial function. Second, we review the evidence supporting the notion that environmental stressors linked to ASD can also adversely affect both mitochondria and GI function. Third, we review the evidence that enteric bacteria that are overrepresented in children with ASD, particularly Clostridia spp., produce short-chain fatty acid metabolites that are potentially toxic to the mitochondria. We provide an example of this gut–brain connection by highlighting the propionic acid rodent model of ASD and the clinical evidence that supports this animal model. Lastly, we discuss the potential therapeutic approaches that could be helpful for GI symptoms in ASD and mitochondrial disorders. To this end, this review aims to help better understand the underlying pathophysiology associated with ASD that may be related to concurrent mitochondrial and GI dysfunction.

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Section: Mitochondrial Disease Is Associated With Gi Disordersmentioning

confidence: 99%

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome

Frye

Rose

Slattery

et al. 2015

Microbial Ecology in Health & Disease

113

View full text Add to dashboard Cite

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Genetic and metabolic liver disease

Rj¹,

Portmann²,

Roberts³

2012

MacSween's Pathology of the Liver

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Developmental and Inherited Liver Disease

Quaglia¹,

Roberts²,

Torbenson³

2018

Macsween's Pathology of the Liver

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Diagnostic approach to histology 113 Neonatal and early infantile liver disease 113 Postneonatal, childhood and adulthood presentation 118 Neonatal hepatitis 119 Histopathological features 120 Biliary atresia 121 Classification and aetiopathogenesis 121 Pathological features at surgical intervention 124 Pathology of intrahepatic changes 126 Paucity of intrahepatic bile ducts 129 Alagille syndrome (arteriohepatic dysplasia) 129 Nonsyndromic duct paucity disorders 131 Bile duct anomalies, congenital dilations and ductal plate malformation disorders 131 Choledochal cyst 132 Hereditary fibropolycystic disease (ductal plate malformation) 133 Cystic fibrosis 141 Hereditary disorders of bile acid synthesis and bilirubin metabolism 143 Primary disorders of bile acid synthesis 143 Disorders of bile canalicular transporters 146 Other diseases causing intrahepatic cholestasis 150 Hereditary defects of bilirubin metabolism 151 Disorders of porphyrin metabolism 153 Porphyria cutanea tarda 154 Erythropoietic protoporphyria 155 Disorders of carbohydrate metabolism and related conditions 156 Glycogen storage diseases (glycogenoses) 156 Myoclonus epilepsy, Lafora type (Lafora disease) 161 Galactosaemia Hereditary fructose intolerance Disorders of glycoprotein and glycolipid metabolism Mucopolysaccharidoses Aspartylglucosaminuria α-Mannosidosis Fucosidosis Mucolipidoses Congenital disorders of glycosylation (carbohydrate-deficient glycoprotein syndrome) Endoplasmic reticulum storage diseases α1-Antitrypsin deficiency α1-Antichymotrypsin deficiency Afibrinogenaemia and hypofibrinogenaemia Antithrombin III deficiency Disorders of amino acid metabolism Hereditary tyrosinaemia type 1 Congenital hyperammonaemia syndromes and urea cycle disorders Cystinosis Homocystinuria (cystathionine β-synthase deficiency) Disorders of lipoprotein and lipid metabolism Abetalipoproteinaemia Familial hypobetalipoproteinaemia Familial high-density lipoprotein deficiency (Tangier disease) Familial hypercholesterolaemia Wolman disease and cholesteryl ester storage disease Gangliosidoses α-Galactosidase A deficiency (Fabry disease) Sulphatide lipidosis (metachromatic leucodystrophy) Chapter 3 Developmental and Inherited Liver Disease

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Cytopathie mitochondriale : une cause inhabituelle d’atrophie villositaire totale chez le nourrisson

Cited by 4 publications

References 7 publications

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome

Genetic and metabolic liver disease

Developmental and Inherited Liver Disease

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