Cytopathologic evaluation of patients submitted to radiotherapy for uterine cervix cancer

Padilha, Cátia Martins Leite; Araujo, Mário Lúcio Cordeiro; Souza, Sérgio Augusto Lopes de

doi:10.1590/1806-9282.63.04.379

Cited by 8 publications

(19 citation statements)

References 32 publications

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“…The CCRT-induced molecular and cellular changes include denaturation and coagulation of proteins, nuclear DNA damage, destruction, and inhibition of protein synthesis. Moreover, the normal cells are also affected with subsequent death or they might persist for several years with nuclear and cytoplasmic changes [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Cytological Study Enlightening the Unseen Effects of Concomitant Chemoradiotherapy in Contralateral Normal Buccal Mucosa of Oral Squamous Cell Carcinoma Patients

Minhas¹,

Sajjad²,

Noor³

et al. 2021

Cureus

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Background/objectivesIn patients receiving concomitant chemoradiotherapy (CCRT) as a treatment for oral squamous cell carcinoma (OSCC), cytological changes were seen not only in neoplastic epithelial cells but the nonneoplastic epithelial cells are also affected, resulting in cytopathological atypical changes. The present study was designed to observe oral epithelial atypical cytopathologic changes induced in contralateral normal buccal mucosa in OSCC patients receiving CCRT. MethodsThe study included 150 patients with OSCC treated by CCRT whose details were collected from the Institute of Nuclear Medicine and Oncology Lahore (INMOL) Hospital Lahore. Cytological smears were obtained from the contralateral normal buccal mucosa of OSCC patients. The serial scrape smears were taken before, immediately after, on the 17th day (mid of treatment), and at the end of CCRT, whereas 20 patients were taken as normal healthy controls and were not exposed to CCRT. The smears were stained with hematoxylin and eosin and Papanicolaou stain. SPSS version 20 (Armonk, NY: IBM Corp.) was used for statistical analysis and p > 0.05 was considered to be significant. ResultsCCRT-induced oral epithelial atypical cytological changes were predominantly noted at end of therapy (19.7%) in the contralateral normal buccal mucosa. Nuclear atypia features were higher on the 17th day and end of treatment; whereas, epithelial atypia was mainly observed on the 17th day of CCRT (40%). A highly significant association was observed between epithelial atypia and radio-chemotherapy dose (p = 0.045), between CCRT-induced epithelial atypical cytological changes and days of treatment (p = 0.001), and between days of CCRT and nuclear atypia (0.000) accordingly. Atypia was not observed in any control group. ConclusionVarying degrees of oral epithelial atypical cytological changes may occur in otherwise normal contralateral mucosa of the patients receiving CCRT.

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Section: Discussionmentioning

confidence: 99%

A Cytological Study Enlightening the Unseen Effects of Concomitant Chemoradiotherapy in Contralateral Normal Buccal Mucosa of Oral Squamous Cell Carcinoma Patients

Minhas¹,

Sajjad²,

Noor³

et al. 2021

Cureus

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“…The delay in diagnosis leads to more aggressive and less effective treatments, increases hospitalization costs and mortality (13) and the survival rate is slightly higher in women diagnosed with CPB (14) .…”

Section: Discussionmentioning

confidence: 99%

Associação entre variáveis demográficas e estadiamento de câncer cervical em idosas: estudo retrospectivo

et al. 2021

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Objetivo: Associar as variáveis sociodemográficas de idosas com câncer cervical e estadiamento de um hospital de referência oncológica. Método: Estudo observacional, retrospectivo e analítico de 559 idosas. Resultados: As variáveis que apresentaram correlação estatística significativa com o estadiamento do câncer do colo do útero foram: idosas casadas, o tipo histopatológico carcinoma de células escamosas, radioterapia + quimioterapia como primeiro tratamento recebido no hospital, remissão completa da doença ao final do primeiro tratamento, sem óbitos por câncer e nunca haver fumado. Discussão: Embora algumas características estarem relacionadas a maior prevalência elas não estavam associadas ao estadiamento. Conclusão: Os dados do estudo reafirmam a necessidade de prevenção e busca ativa dos casos. Conhecer as características epidemiológicas dessas idosas, torna-se significativo, pois fornece subsidio para o planejamento avaliação de programas efetivos no controle do câncer do colo do útero.

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“…DNA of the cell gets damaged by lysis and gene mutation due to both direct effect (ionizing) and indirect (free radical formation) of radiation. [ 4 ]…”

Section: How Does Rt Work?mentioning

confidence: 99%

Cervical cytology: Radiation and other therapy effects

Poflee

Bhatia

2022

Cytojournal

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The different treatment options for carcinoma cervix include radiation, chemotherapy, and surgical treatments. Cytological analysis of smears is crucial for patient follow-up to determine response to therapy and to diagnose the persistence or recurrence of malignancy. Anatomical alterations and changes in cell morphology following radiation or chemotherapy make collecting and interpreting cervical cytology samples difficult. These issues can be mitigated by liquid-based cytology. Ionizing radiation is used in radiotherapy (RT) to kill cells. It is important that cytologists are aware of alterations in morphology of the cells. Radiation can cause cytoplasmic and nuclear changes. Cellular enlargement, vacuolation, granularity loss, and other changes linked with cell death are examples of cytoplasmic alterations. Nuclear enlargement and multinucleation are the most frequent nuclear alterations. These changes are determined by the amount of time that has passed since radiation. It should be emphasized that no one characteristic is pathognomonic. Post-irradiation dysplasia is a condition described as abnormal cellular changes in non-neoplastic epithelial cells after RT. Chemotherapy causes comparable alterations as radiation but impacts fewer cells. Busulfan and other chemotherapeutic treatments may produce morphological alterations, which cytologists must be aware of and able to identify. Immunosuppressive treatments, hormonal therapy, and tamoxifen are some of the other drugs that might cause changes in cervical morphology. Surgical methods used in the detection and treatment of cervical cancer may potentially cause alterations as a result of thermal damage and healing. For the treatment of cervical lesions, electrocautery and the loop electrosurgical excisional procedure are available. These procedures employ electric current ablation leading to ischemic changes in the cervical smear. Cytological analysis of smears following treatment with these modalities necessitates a comprehensive history, kind of therapy, and duration of treatment.

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Cytopathologic evaluation of patients submitted to radiotherapy for uterine cervix cancer

Cited by 8 publications

References 32 publications

A Cytological Study Enlightening the Unseen Effects of Concomitant Chemoradiotherapy in Contralateral Normal Buccal Mucosa of Oral Squamous Cell Carcinoma Patients

A Cytological Study Enlightening the Unseen Effects of Concomitant Chemoradiotherapy in Contralateral Normal Buccal Mucosa of Oral Squamous Cell Carcinoma Patients

Associação entre variáveis demográficas e estadiamento de câncer cervical em idosas: estudo retrospectivo

Cervical cytology: Radiation and other therapy effects

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