Cytopathological diagnosis of hyalinising trabecular tumour, a rare thyroid neoplasm

Agarwal, Shikha; Mathur, S. B.; R, Ray; Sharma, Shilpa; Sinha, Poonam

doi:10.1111/j.1365-2303.2010.00744.x

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The challenges to solving the problem of presurgical diagnostics are 3‐fold: First, some of the key cytologic features of PTC and medullary thyroid carcinoma, such as enlarged oval nuclei, nuclear grooves, and intranuclear pseudoinclusions, are typically seen in HTT (Fig. ) . Tabulation of the cytology diagnoses standardized into the Bethesda System for Reporting Thyroid Cytopathology showed that 42.1% and 26.4% of HTT cases were diagnosed on FNA as suspicious for malignancy (Bethesda V) and malignant (Bethesda VI), respectively (Table ), which often triggered total thyroidectomy.…”

Section: Cytologic Challenges Resulting From Httmentioning

confidence: 99%

“…Third, the relative rarity of HTT has limited the opportunity for general cytopathologists to become proficient in recognizing the key cytologic features this entity. Although the exact incidence is not known, the finding that 11 of 26 reports (42%) documenting the cytology of HTT are individual case reports is likely a reflection of its rarity . Therefore, heightened awareness of the subtle cytologic features of HTT and the availability of novel, specific molecular markers are important in the presurgical identification of this neoplasm.…”

Section: Cytologic Challenges Resulting From Httmentioning

confidence: 99%

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GLIS rearrangements in thyroid nodules: A key to preoperative diagnosis of hyalinizing trabecular tumor

Nikiforova

Nikiforov

Ohori

2019

Cancer Cytopathology

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Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm with peculiar morphologic features that overlap with those of papillary thyroid carcinoma (PTC). Specifically, the presence of enlarged oval nuclei, nuclear grooves, and intranuclear pseudoinclusions makes precise cytopathologic diagnosis challenging. If the cytopathologic diagnosis is suspicious for malignancy (Bethesda V) or is malignant (Bethesda VI), a total thyroidectomy, which would be considered an overtreatment, may follow. The recent discovery of the strong association between GLIS fusions and HTT sheds light on its pathogenesis and offers a pathway for its presurgical identification. Although the number of cases analyzed is limited, the recent landmark study shows that GLIS fusions are highly specific for HTT and that lobectomy is the likely appropriate surgical treatment, because these neoplasms, which lack invasion, are benign. For overall success, cytopathologic recognition of the subtle features is important to avoid false-positive diagnoses and directing potential HTT cases toward indeterminate cytopathologic diagnoses, which would trigger further molecular testing. Additional studies are needed to determine whether a malignant counterpart of GLIS fusion-positive HTT exists and if more conservative approaches may be taken.Hyalinizing trabecular tumor (HTT) is a rare type of thyroid neoplasm with peculiar morphology, and there is long-standing controversy with respect to its relationship to papillary carcinoma and clinical behavior. A recent study has described a unique molecular profile of these tumors, ending this controversy and paving the way for efficient preoperative detection of these tumors and guiding patients toward optimal management. 1

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Section: Cytologic Challenges Resulting From Httmentioning

confidence: 99%

Section: Cytologic Challenges Resulting From Httmentioning

confidence: 99%

GLIS rearrangements in thyroid nodules: A key to preoperative diagnosis of hyalinizing trabecular tumor

Nikiforova

Nikiforov

Ohori

2019

Cancer Cytopathology

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Authors attain comparable or slightly higher rates of citation publishing in an open access journal (CytoJournal) compared to traditional cytopathology journals - A five year (2007-2011) experience

et al. 2014

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Background:The era of Open Access (OA) publication, a platform which serves to better disseminate scientific knowledge, is upon us, as more OA journals are in existence than ever before. The idea that peer-reviewed OA publication leads to higher rates of citation has been put forth and shown to be true in several publications. This is a significant benefit to authors and is in addition to another relatively less obvious but highly critical component of the OA charter, i.e. retention of the copyright by the authors in the public domain. In this study, we analyzed the citation rates of OA and traditional non-OA publications specifically for authors in the field of cytopathology.Design:We compared the citation patterns for authors who had published in both OA and traditional non-OA peer-reviewed, scientific, cytopathology journals. Citations in an OA publication (CytoJournal) were analyzed comparatively with traditional non-OA cytopathology journals (Acta Cytologica, Cancer Cytopathology, Cytopathology, and Diagnostic Cytopathology) using the data from web of science citation analysis site (based on which the impact factors (IF) are calculated). After comparing citations per publication, as well as a time adjusted citation quotient (which takes into account the time since publication), we also analyzed the statistics after excluding the data for meeting abstracts.Results:Total 28 authors published 314 publications as articles and meeting abstracts (25 authors after excluding the abstracts). The rate of citation and time adjusted citation quotient were higher for OA in the group where abstracts were included (P < 0.05 for both). The rates were also slightly higher for OA than non-OA when the meeting abstracts were excluded, but the difference was statistically insignificant (P = 0.57 and P = 0.45).ConclusionWe observed that for the same author, the publications in the OA journal attained a higher rate of citation than the publications in the traditional non-OA journals in the field of cytopathology over a 5 year period (2007-2011). However, this increase was statistically insignificant if the meeting abstracts were excluded from the analysis. Overall, the rates of citation for OA and non-OA were slightly higher to comparable.

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Cytopathological diagnosis of hyalinising trabecular tumour, a rare thyroid neoplasm

Cited by 2 publications

References 6 publications

GLIS rearrangements in thyroid nodules: A key to preoperative diagnosis of hyalinizing trabecular tumor

GLIS rearrangements in thyroid nodules: A key to preoperative diagnosis of hyalinizing trabecular tumor

Authors attain comparable or slightly higher rates of citation publishing in an open access journal (CytoJournal) compared to traditional cytopathology journals - A five year (2007-2011) experience

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