Cytopathological features of villous adenoma of the urinary bladder in urine: A rare case report

Ishikawa, Ryou; Kadota, Kyuichi; Hayashi, Toshitetsu; Motoyama, C T Mutsumi; Matsunaga, C T Toru; Miyai, Yumi; Katsuki, Naomi; Kushida, Yoshio; Haba, Reiji

doi:10.1002/dc.23488

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…28 In these cases, bland-appearing glandular epithelial cells can be interpreted as benign glandular elements as seen in cystitis glandularis (Figs. 5A, B) or, as reported by Ishikawa et al, 29…”

Section: Adenocarcinomasupporting

confidence: 59%

An Approach to Nonurothelial Malignancies of the Urinary Bladder in Urine Cytology

Lew

2022

Advances in Anatomic Pathology

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Urine cytology is an economical and convenient method of triaging patients who present with urinary symptoms as well as surveying those who have previously been diagnosed with urothelial carcinoma for recurrent or persistent disease. While the vast majority of malignancies diagnosed in urine cytology are urothelial carcinomas, it is important to recognize nonurothelial elements to inform patient prognosis and raise the possibility of involvement by a urothelial carcinoma variant, nonurothelial malignancy of the bladder, or a nonbladder primary, which may alter patient management pathways. As such, becoming familiar with morphologic features of nonurothelial malignancies in urine cytology as well as their related clinical risk factors, radiologic and cystoscopic features, differential diagnostic considerations, and the utility and pitfalls of ancillary tests can facilitate optimal patient care.

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Section: Adenocarcinomasupporting

confidence: 59%

An Approach to Nonurothelial Malignancies of the Urinary Bladder in Urine Cytology

Lew

2022

Advances in Anatomic Pathology

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“…However, cytologic descriptions of cytomorphologic features of these variants remain less defined for daily practice. Several studies have evaluated cytology findings of histologic variants of UC, 5,8,9,11,12,14,18,19 but most studies focused on micropapillary subtype. Only a few cases mentioned other subtypes, such as sarcomatoid variant, squamous differentiation, and glandular differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…Although histologic variants are relatively well‐recognized among pathologists in biopsy and resection specimens, the cytologic features of these variants in urinary specimens have received limited attention in the literature. Few case reports and studies detail the urinary cytomorphologic findings of histologic variants of UC 5‐14 . Given that urine cytology is the current gold standard for bladder cancer screening, early suspicion of aggressive UC variants on urine cytology can give guidance for clinicians to make better treatment decision for UC patients.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of urine cytology in detecting histologic variants of urothelial carcinomas in the urinary bladder: Cytopathologic correlation of 72 cases

Yoo

Choi

Lee

et al. 2020

Diagnostic Cytopathology

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Background Precise identification of histologic variants in urothelial carcinoma (UC) is important because some histologic types have a poor prognosis and clinical management varies. Urine cytology is used for bladder cancer screening, but the cytomorphologic features of histologic variants have not been well described. In the current study, we evaluate the effectiveness of urine cytology in detecting histologic variants of UC in the urinary bladder. Methods Seventy‐two urine cytology specimens from patients diagnosed with high‐grade UCs by radical cystectomy were retrospectively reviewed and correlated with histopathologic findings of subsequent radical cystectomy specimens. Results Of 72 total cases, 24 (33%) cases showed six histologic variants in corresponding surgical specimens, including squamous differentiation (13 cases), plasmacytoid variant (3 cases), micropapillary variant (3 cases), sarcomatoid variant (3 cases), giant cell variant (1 case), and glandular differentiation (1 case). Histopathology and cytomorphology were well correlated in 13 cases (54%), with squamous differentiation in 11 of 13 cases (85%), micropapillary features in 1 out of 3 cases (33%), and spindle cell/sarcomatoid features in 1 of 3 cases (33%). Furthermore, mucosal involvement by histologic variants, not amount of histologic variant, was related to high concordance rates between cytology and histology diagnosis. Conclusions The morphologic features of some histologic variants of high‐grade UCs, such as squamous differentiation, micropapillary variant, and sarcomatoid variant, are partially reflected on urine cytology. In addition, mucosal involvement by histologic variants was associated with a higher detection rate of histologic variants in urine cytology.

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“…The identification of glandular morphology in urine sample is difficult and only a few anecdotal case reports are present exemplifying and documenting this issue. [31][32][33] Urine cytology of VA shows clusters of mucin-filled columnar cells. 33 The identification of both transitional epithelium with atypia and glandular epithelium should arouse suspicion of a UCVGD in urine cytology.…”

Section: Role Of Urine Cytologymentioning

confidence: 99%

“…[31][32][33] Urine cytology of VA shows clusters of mucin-filled columnar cells. 33 The identification of both transitional epithelium with atypia and glandular epithelium should arouse suspicion of a UCVGD in urine cytology. However, the glandular lesions of urinary bladder are relatively uncommon and a suspicion/diagnosis in urine cytology is challenging.…”

Section: Role Of Urine Cytologymentioning

confidence: 99%

Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis

2019

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Villous morphology in urinary bladder biopsy is a relatively uncommon finding. Villi are slender, finger-like structures that are commonly seen in the small intestine or in neoplastic lesions of gastrointestinal lineage/differentiation. Importantly, placenta also exhibits villi that are morphologically and functionally different from the intestinal one. Majority of the neoplastic lesions of urinary bladder are urothelial in origin with a minor subset showing glandular differentiation. While the presence of benign villi in urinary bladder biopsy necessitates a search for an occult perforation, provided a sample mismatch is ruled out, cytoarchitecturally abnormal/dysplastic villi indicate a neoplastic lesion of the urinary bladder encompassing villous adenoma and adenocarcinoma and urothelial carcinoma with villoglandular differentiation. The dysplastic villi in urinary bladder also imply a lower gastrointestinal endoscopy to rule out a colorectal primary. The development of the villous lesions in the urinary bladder and the colorectum are embryologically related and pose a major diagnostic challenge to the clinicians and surgical pathologists due to identical histomorphology and immunohistochemistry. We tend to discuss the morphological differentials and diagnostic approach to the villous lesions in the urinary bladder biopsy.

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Cytopathological features of villous adenoma of the urinary bladder in urine: A rare case report

Cited by 7 publications

References 7 publications

An Approach to Nonurothelial Malignancies of the Urinary Bladder in Urine Cytology

An Approach to Nonurothelial Malignancies of the Urinary Bladder in Urine Cytology

Diagnostic value of urine cytology in detecting histologic variants of urothelial carcinomas in the urinary bladder: Cytopathologic correlation of 72 cases

Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis

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