Cytopathology of solitary fibrous tumor: a series of 34 cases

Wakely, Paul E.; Rekhi, Bharat

doi:10.1016/j.jasc.2021.03.005

Cited by 14 publications

(22 citation statements)

References 51 publications

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“…Only 1 of our SFT cases had any IHC staining, and without a STAT6 stain, the IHC panel was phenotypically nonspecific. In a large collection of 34 SFT cases from various body sites, only 9% were diagnosed exactly as SFT 20 . Bauer et al 40 describe the cytologic diagnosis of SFT as very challenging in their single case report and a literature review of 7 patients having preoperative PG FNA.…”

Section: Discussionmentioning

confidence: 99%

“…In a large collection of 34 SFT cases from various body sites, only 9% were diagnosed exactly as SFT. 20 Bauer et al 40 describe the cytologic diagnosis of SFT as very challenging in their single case report and a literature review of 7 patients having preoperative PG FNA. They state that the majority were interpreted as either PA or cementifying fibroma.…”

Section: Discussionmentioning

confidence: 99%

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Mesenchymal neoplasms of the parotid gland and parapharyngeal space: an FNA cytologic study of 22 nonlipomatous tumors

Wakely

2022

Cancer Cytopathology

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BACKGROUND Mesenchymal neoplasms of the parotid gland (PG) and para‐pharyngeal (PP) space are distinctly uncommon. Fine‐needle aspiration (FNA) biopsy experience with nonlipomatous neoplasms from this site is reviewed. METHODS Cytopathology and surgical pathology files were examined for mesenchymal PG and PP space neoplasms. FNA biopsy was performed using standard technique. RESULTS Twenty‐two PG and/or PP aspirates from 20 adults (male:female = 1.1:1; age range, 19‐84 years, mean age, 50 years) and a 10‐week‐old infant met inclusion criteria. Biopsy sites included PG (17, 77%) or PP space (5, 23%). Five of 6 malignant neoplasms (83%) were called malignant cytologically. Only 7 of 11 (63%) benign neoplasms were recognized as a benign neoplasm. None of 5 solitary fibrous tumor (SFT) cases were correctly recognized. Conversion to the Milan classification showed 8 (36%) FNA cases diagnosed as benign neoplasm, 6 (27%) malignant neoplasm, 4 (18%) neoplasm of uncertain malignant potential, 2 (9%) nondiagnostic, and single cases of suspicious for malignancy and nonneoplastic. There was 1 false‐positive and no false‐negative FNA diagnoses. Ancillary testing in 10 (45%) aspirates helped substantiate a correct specific diagnosis in 3 malignant and 3 benign cases. CONCLUSIONS FNA biopsy of nonlipomatous mesenchymal SG neoplasms is particularly challenging. Less than half (9 of 11, 41%) had specific FNA diagnoses that correctly matched the tissue diagnoses or clinical outcome. Accurate Milan categorization was superior for malignant neoplasms (5 of 6, 83%) in contrast to benign neoplasms (7 of 11, 63%), or neoplasms of uncertain malignant potential (SFT) (2 of 5, 40%).;

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mesenchymal neoplasms of the parotid gland and parapharyngeal space: an FNA cytologic study of 22 nonlipomatous tumors

Wakely

2022

Cancer Cytopathology

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“…These findings are similar to those described in prior series with cytologic evaluation of SFTs from a variety of anatomic sites. 7,8 Of note, the cytologic diagnosis of SFT can be a challenge, as highlighted in a recent series of 34 tumors where a specific diagnosis of SFT was rendered in only 9% of cases. 8 This finding emphasizes the morphologic ambiguity of SFT and the necessity of material for IHC.…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the pancreas clinically mimicking a pancreatic neuroendocrine tumor: Cytologic pitfalls when a transgastric approach is utilized

Marotti

Jamot

et al. 2021

Diagnostic Cytopathology

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Solitary fibrous tumor (SFT) involving the pancreas is a rare entity often diagnosed on surgical specimens rather than cytology samples. Pancreatic SFT frequently mimics pancreatic neuroendocrine tumor radiographically, which presents unique challenges to the cytologist during rapid on-site assessment. We describe a case of pancreatic SFT with a focus on the cytologic pitfalls that might be encountered during transgastric procedures. We also review the available cytologic findings of prior pancreatic SFT cases.

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“…The cytomorphological diagnosis includes spindle cell neoplasm, sarcoma, "suspect sarcoma", round cell tumour and mesenchymal tumour. [34][35][36] In one of the largest series on the cytomorphological spectrum of 34 specimens from 30 patients with SFT, Wakely and…”

Section: Solitary Fibrous Tumourmentioning

confidence: 99%

Pitfalls in soft tissue cytopathology

Rekhi,

Qian,

Domanski

et al. 2023

Cytopathology

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Fine needle aspiration biopsy (FNAB) is a diagnostic modality for the evaluation of suspicious soft tissue masses. Despite its reasonable sensitivity, specificity and positive predictive value in differentiating benign from malignant neoplasms, the exact subtyping of the primary soft tissue tumours can be challenging. Certain tumours constitute “pitfalls” and add to the diagnostic challenge. This review provides a detailed account of the diagnostic challenges in soft tissue cytopathology, including pitfalls and, more importantly, the ways to overcome these challenges by integrating clinical details, key cytomorphological features and judicious application of ancillary techniques.

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Cytopathology of solitary fibrous tumor: a series of 34 cases

Cited by 14 publications

References 51 publications

Mesenchymal neoplasms of the parotid gland and parapharyngeal space: an FNA cytologic study of 22 nonlipomatous tumors

Mesenchymal neoplasms of the parotid gland and parapharyngeal space: an FNA cytologic study of 22 nonlipomatous tumors

Solitary fibrous tumor of the pancreas clinically mimicking a pancreatic neuroendocrine tumor: Cytologic pitfalls when a transgastric approach is utilized

Pitfalls in soft tissue cytopathology

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