Cytophagic Histiocytic Panniculitis (Chp)

Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore

“…These compounds develop their pharmacological action via the specific inhibition of the subunit-A of the bacterial topoisomerase DNA girase, which controls the shape of DNA [2]. Particular attention was devoted to the light induced degradation of FLQs, as proven by several reports dealing with adverse cutaneous reactions and in vitro phototoxicity through photosensitization under UVA irradiation [3][4][5][6][7][8][9][10][11]. In addition, even photocarcinogenic consequences were reported [12][13][14].…”