Cytoplasmic Genetic Effects and Growth of Hybrid Mice

Dr, Brown; Sk, DeNise; Rg, McDaniel

doi:10.2527/jas1989.674887x

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…oxygen consumption, ADP:O 2 ratio and ATP synthesis) but found very little association between mitochondrial metabolism and growth traits in beef cattle although in dairy cattle there tended to be a positive correlation between mitochondrial-related variables and performance, principally in respect to milk yield. In a similar experiment with mice, Brown et al (1989) found no differences in growth traits related to cytoplasmic genetic effects between inbred lines, even though there were differences in mitochondrial metabolic activity. Lindberg et al (1989) were able to detect a higher production efficiency of ATP in mammary gland mitochondria derived from a mouse line selected for high milk production as compared to a line selected for low milk production.…”

Section: Discussionmentioning

confidence: 85%

Effects of cytoplasmic inheritance on preweaning traits of Hereford cattle

et al. 2005

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The influence of cytoplasmic inheritance on birth and weaning weight was evaluated in an experimental Hereford herd. Data on 1,720 records for birth and weaning weights from calves born between 1963 and 2002 were studied. Variance components were estimated using MTDFREML procedures and an animal model was fitted for each trait. Direct and maternal additive effects and permanent environment and maternal lineage effects were treated as random, while year and month of birth, age of dam and sex of the calf were treated as fixed. Identification of maternal lineages was based on pedigree information. The contribution to phenotypic variance of cytoplasmic lineages defined by pedigree information was negligible for both traits. Mitochondrial genotypes of cows present in the herd in 2002 were analyzed by single strand conformation polymorphism (SSCP) analysis. Only five different genotypes were identified among 23 maternal lineages. All the animals with records were assigned to maternal genotypes based on pedigree information. The statistical analysis was repeated, removing maternal lineage from the model and including mitochondrial genotype as a fixed effect. No evidence of genotype effects was detected. These results suggest a negligible effect of the mitochondrial genome on the preweaning traits of this Hereford herd.

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Section: Discussionmentioning

confidence: 85%

Effects of cytoplasmic inheritance on preweaning traits of Hereford cattle

et al. 2005

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Decreased physical performance of congenic mice with mismatch between the nuclear and the mitochondrial genome.

et al. 1998

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Maternal transmission of mitochondrial DNA (mtDNA) allows us to generate mtDNA congenic strain by repeating backcrosses of female mice to male mice of an inbred strain, which carries different mtDNA haplotype from that of the female progenitor. Since genetic backgrounds of inbred strains commonly used (e.g., C57BL/ 6J [B6] and BALB/c) are mainly derived from an European subspecies of Mus musculus domesticus, congenic strains, in which mtDNA originated from an Asian subspecies M. musculus musculus or an European species M. spretus, give in vivo condition that mismatch occurs between the mitochondrial and the nuclear genome. So far, little has been known how the mismatch condition affects the physiological phenotype of the mice. To address this question, we established two mtDNA congenic strains, C57BL/6J(B6)-mt SPR and BALB/c-mt SHH , which carry M. spretus-and M. m. musculus-derived mtDNAs, representing the conditions of interspecific and intersubspecific mitochondrial-nuclear genome mismatch, respectively. Using these congenic strains, we examined their physical performance by measuring their running time on a treadmill belt until exhaustion. The result clearly showed that the mtDNA congenic strains manifested a significant decrease in the level of physical performance, when compared with their progenitor strains. It also appeared that the congenic mice manifested growth rate. Thus, all results indicated that mismatch between the mitochondrial and the nuclear genome causes phenotypic changes in individuals of mice.

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Cytoplasmic Genetic Effects and Growth of Hybrid Mice

Cited by 2 publications

References 12 publications

Effects of cytoplasmic inheritance on preweaning traits of Hereford cattle

Effects of cytoplasmic inheritance on preweaning traits of Hereford cattle

Decreased physical performance of congenic mice with mismatch between the nuclear and the mitochondrial genome.

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