Cytoprotective and antioxidant effects of the methanol extract of &lt;i&gt;Eremomastax Speciosa&lt;/i&gt; in rats

Amang, Perfusion A.; Tan, Paul V.; Patamaken, Simon A.; Mefe, Martial N.

doi:10.4314/ajtcam.v11i1.26

Cited by 16 publications

(19 citation statements)

References 21 publications

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“…Overproduction of ROS/RNS activates lipid peroxidation, evidenced by increased MDA levels in gastric mucosa at 24 hours after burn trauma. It has been reported that the increased lipid peroxidation levels in plasma (19,28) and gastric mucosa (29), and the decreased antioxidant defense cause oxidative damage of gastric mucosa, induced by burns (29), NSAID, ethanol, cold/restraint stress treatment (30).…”

Section: Discussionmentioning

confidence: 99%

Heme oxygenase-1 expression and oxidative stress - related markers in gastric mucosa in skin burns and protection with melatonin

Hristova¹,

Bekyarova²,

Tzaneva³

2016

TJS

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Melatonin, a major hormone of pineal gland, was recently show to attenuate acute gastric lesions induced by strong irritants because of the scavenging of free radicals. The effect of melatonin on burninduced gastric mucosal injury due to the skin burn is unclear. PURPOSE: This study investigated heme oxygenase-1 and markers linked with oxidative stress in gastric mucosa and the effect of melatonin in burn rat model. METHODS: Melatonin was applied immediately and 12 hours after 30% of total body surface area burns. Using light immunohistochemistry the expression of gastric mucosal inducible nitric oxide synthase (iNOS) and heme oxygenase (HO-1) was found out. Malondialdehyde (MDA) as a marker of oxidative injury was determined in gastric mucosa by the thiobarbituric acid method. RESULTS: Gastric MDA and iNOS levels were increased significantly after severe burn (p<0.05, p<0.0001, respectively). The increased HO-1 expression in the burned group was found out (p<0.05). Melatonin restricted the increased MDA (p<0.05) and iNOS (p<0.05) levels, and augmented the increase in HO-1 expression in gastric mucosa (p<0.05). In conclusion, melatonin ameliorates gastric mucosal injury via induction of antioxidant enzyme HO-1 and inhibition of oxidative stress beyond local burn skin injury.

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Section: Discussionmentioning

confidence: 99%

Heme oxygenase-1 expression and oxidative stress - related markers in gastric mucosa in skin burns and protection with melatonin

Hristova¹,

Bekyarova²,

Tzaneva³

2016

TJS

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“…Diabetes mellitus is a risk factor for erectile dysfunction [ 36 ], and long-term use of histamine H 2 receptor antagonists (e.g., Cimetidine) in gastroduodenal ulcer treatment leads to reduced libido. E. speciosa has been cited for its ethnopharmacological application in diabetes management [ 14 ] and other workers [ 10 , 37 ] have reported the cytoprotective and antisecretory effects of E. speciosa extract in peptic ulcer management. Therefore E. speciosa extract may have possible long-term benefits in sustaining increased levels of libido especially when used to treat conditions that represent risk factors for erectile dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the display of pelvic thrusting during intromission and ejaculation by the extract-treated animals in this study further indicated that the male copulatory organ was in contact with the vaginal orifice which might have activated or strengthened lordosis in the female rats. A postejaculatory interval (PEI) of more than 5400 seconds indicates that the male is sexually exhausted and the intensity of sexual behavior will be reduced in subsequent mating [ 37 ]. In addition, reduction of the postejaculatory interval (PEI) is also an indication of sustained increase in sexual activity [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Aqueous Extract ofEremomastax speciosa(Acanthaceae) on Sexual Behavior in Normal Male Rats

Nchegang

Mezui

Longo

et al. 2016

BioMed Research International

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Objective. We studied prosexual effects of Eremomastax speciosa aqueous extract in male adult rats. Materials and Methods. 100 and 500 mg/kg of extract were administered orally (days 0, 1, 4, 7, 14, and 28 (posttreatment)). The sexual behavior of rats receiving a single dose (500 mg/kg) was also evaluated after pretreatment with Lω-NAME (10 mg/kg), haloperidol (1 mg/kg), or atropine (5 mg/kg). Controls received distilled water or testosterone enanthate (20 mg/kg/day/3 days (s.c.) before the test). Results. The extract (days 1–14) had no significant effect on mount, intromission, and ejaculation frequencies but on day 28 (14 days after treatment), it increased frequency of mounts and intromissions at 500 mg/kg. Mount, intromission, and ejaculation latencies reduced and postejaculatory intervals decreased but the effect did not persist 2 weeks after treatment. Extract prosex effects were greatly reduced by atropine and completely abolished by haloperidol, while Lω-NAME increased mount latency and potentiated extract effect on intromission and ejaculation latencies. Conclusion. In summary, E. speciosa extract can have positive effects on male sexual motivation and performance when administered for two weeks at the dose of 500 mg/kg. The effects (dopaminergic and/or cholinergic dependent) tend to appear during the posttreatment period.

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“…Thus, in a preliminary study, the water extract of E. speciosa significantly inhibited the formation of gastric lesions induced by HCl/ethanol and pylorus ligation [ 16 ]. Subsequent studies demonstrated the cytoprotective and antioxidant activities of the methanolic extract against various experimental ulcer models [ 17 ]. Other works demonstrated that the antisecretory action of the aqueous extract occurs through a mechanism common to both antihistaminic and anticholinergic pathways [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Healing and Antisecretory Effects of Aqueous Extract ofEremomastax speciosa(Acanthaceae) on Unhealed Gastric Ulcers

Amang

Mezui

Siwe

et al. 2017

BioMed Research International

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Objective This work investigated the healing and antisecretory effects of the aqueous extract of Eremomastax speciosa on “unhealed gastric ulcers” associated with gastric acid hypersecretion. Materials and Methods “Unhealed gastric ulcers” were induced using indomethacin following the establishment of acetic-acid-induced chronic gastric ulcers. The extract (200 and 400 mg/kg, per os) was administered concomitantly with indomethacin (1 mg/kg, subcutaneously). The effects of the extract on both basal and histamine-stimulated gastric acid secretion were determined. Mucus secretion and oxidative stress parameters were measured, and histological assessment of ulcer healing was carried out. Results The extract significantly promoted the healing process in rats subjected to “unhealed gastric ulcers” (82.4–88.5% healing rates). Treatment with the extract significantly reduced the basal (25.95–49.51% reduction rates) and histamine-stimulated (24.25–47.41%) acid secretions. The healing effect of the extract was associated with a significant (p < 0.05) increase of mucus secretion and concentrations of antioxidant enzymes compared with the controls. The extract at the highest dose showed normalization of the mucosa, without glandular destruction and with the disappearance of fibrosis and lymphocyte infiltration. Conclusion The abilities of the extract to increase mucus secretion, to reinforce antioxidant status, and to inhibit acid secretion would be some of the mechanisms by which this extract would accelerate the healing process in “unhealed gastric ulcers.”

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Cytoprotective and antioxidant effects of the methanol extract of <i>Eremomastax Speciosa</i> in rats

Cited by 16 publications

References 21 publications

Heme oxygenase-1 expression and oxidative stress - related markers in gastric mucosa in skin burns and protection with melatonin

Heme oxygenase-1 expression and oxidative stress - related markers in gastric mucosa in skin burns and protection with melatonin

Effects of the Aqueous Extract ofEremomastax speciosa(Acanthaceae) on Sexual Behavior in Normal Male Rats

Healing and Antisecretory Effects of Aqueous Extract ofEremomastax speciosa(Acanthaceae) on Unhealed Gastric Ulcers

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