Abstract:Carcinogenesis induced chemically produces mutations affecting standard cells' behavior. An electrophilic attack on DNA result as the primary characteristic. Once xenobiotics are administrated to mammals they suffer a metabolic activation in the liver through cytochrome P450 (CYP450) enzymes, converting them to toxic compounds, generating oxidative stress (OS), and bursting electrophiles near the site of oxidation. CYP450 are electron carrier proteins that generate spin-correlated radical pair (RP) intermediar… Show more
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