2024
DOI: 10.7759/cureus.65566
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Cytoprotective Effect of Growth Factors Derived From Platelets on Corticosteroid-Treated Primary Anterior Cruciate Ligament-Derived Stromal Cells and Chondrocytes

Vijay Sharma,
Ulka Sakhalkar,
Pratiksha Nadkarni
et al.

Abstract: BackgroundThe use of corticosteroids, such as methylprednisolone, for pain management is a common clinical practice. However, it is well known that corticosteroids induce toxicity in anterior cruciate ligament (ACL)-derived stromal cells and chondrocytes. Growth factors from platelets have anti-inflammatory effects that can potentially limit the cytotoxic effects of corticosteroids. In this study, we explored the role of growth factors obtained from the Ossinext TM kit (commercially available Wockhardt growth … Show more

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