Cytoprotective effect of taurine against sodium chlorate-induced oxidative damage in human red blood cells: an ex vivo study

Ali, Shaikh Nisar; Arif, Amin; Ansari, Firoz Ahmad; Mahmood, Riaz

doi:10.1007/s00726-021-03121-5

Cited by 10 publications

(9 citation statements)

References 80 publications

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“…These data demonstrate that GCs strongly promote Tau secretion and spreading in vivo. To assess whether this spreading occurs via type 1 UPS, we initiated a second hTau spreading experiment with epigallocatechin gallate (EGCG), a potent inhibitor of Tau aggregation that attenuates its secretion via type 1 UPS 37,47 and can be used in vivo, unlike other inhibitors of type 1 UPS 48,49 . We rst veri ed the ability of EGCG to reduce GC-induced Tau secretion in brain slices (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…However, EGCG also alters lipid membrane properties 51,52 and could alter Tau secretion/uptake via this mechanism. Other drugs that block type 1 UPS, such as NaClO 3 and methyl-b-cyclodextrin, have similarly pleiotropic effects (and further cannot be used in vivo due to their blood brain barrier impermeability and toxicity, respectively 48,49 ), making it di cult to de nitively demonstrate that secretion via type 1 UPS is the primary driver of GC-induced Tau propagation in vivo. However, given the relative amount of Tau reported to undergo secretion in vesicle-free form (~ 90%) 22 , we think it is reasonable to assume that type 1 UPS contributes substantially to GC-induced Tau spreading in vivo.…”

Section: Discussionmentioning

confidence: 99%

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Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain

Waites

Qian

et al. 2023

Preprint

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Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer’s disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic Tau protein between brain regions, precipitated by neuronal Tau secretion. While stress and high GC levels are known to induce intraneuronal Tau pathology (i.e. hyperphosphorylation, oligomerization) in animal models, their role in trans-neuronal Tau spreading is unexplored. Here, we find that GCs promote secretion of full-length, vesicle-free, phosphorylated Tau from murine hippocampal neurons and ex vivo brain slices. This process occurs via type 1 unconventional protein secretion (UPS) and requires neuronal activity and the kinase GSK3b. GCs also dramatically enhance trans-neuronal Tau spreading in vivo, and this effect is blocked by an inhibitor of Tau oligomerization and type 1 UPS. These findings uncover a potential mechanism by which stress/GCs stimulate Tau propagation in AD.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain

Waites

Qian

et al. 2023

Preprint

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“…7). On the other hand, several studies have revealed the exciting effects of TAU on erythrocytes [38][39][40][41][42][43]. TAU is not considered a classic radical scavenger or a regulator of cellular antioxidant defense mechanisms [145][146][147].…”

Section: •-mentioning

confidence: 99%

“…Several studies have also mentioned the positive effects of TAU on erythrocytes [38][39][40][41][42][43]. In this regard, TAU significantly suppressed oxidative stress and its associated complications, such as lipid peroxidation and protein carbonylation in erythrocytes exposed to toxic insults [39][40][41][42][43]. TAU also significantly enhanced the level of antioxidant enzymes such as catalase, superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase in erythrocytes [39,40,42,43].…”

Section: Introductionmentioning

confidence: 99%

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Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

Niknahad¹,

Mehrabani²,

Arjmand³

et al. 2023

ceh

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Aim of the study: Cholestasis/cirrhosis could induce erythrocyte lysis. The incidence of various types of anemia in cirrhosis is approx. 75%. Several studies have mentioned the pivotal role of oxidative stress in this complication. Taurine (TAU) is the human body's most abundant free amino acid. TAU is known as a robust cell membrane stabilizer. Many studies have mentioned that TAU could counteract oxidative stress in various experimental models. The current study was intended to evaluate the effect of TAU on erythrocytes in cirrhotic rats. Material and methods: Bile duct ligation (BDL) surgery was carried out on rats. Then, complete blood count (CBC), hemoglobin (Hgb), hematocrit (HTC), and erythrocytes' G6PD, catalase (CAT), and superoxide dismutase (SOD) activity were measured. Moreover, biomarkers of oxidative stress were assessed, and the erythrocytes' morphological changes were monitored in the cirrhotic mice exposed to TAU (0.25%, 0.5%, and 1% w : v in drinking water). Results: Significant changes in the assessed erythrocyte parameters (G6PD activity, Hgb, HTC, and erythrocyte count) and red blood cells (RBC) morphological alterations were detected on day 42 after BDL surgery. Biomarkers of oxidative stress also did not change at the time points, except on post-BDL days 28 and 42. A significant decrease in blood parameters was evident at post-BDL day 42. All doses of TAU (0.25%, 0.5%, and 1% w : v in drinking water) significantly improved erythrocyte parameters and encountered oxidative stress in the erythrocytes of cirrhotic animals. Conclusions: These data indicate that TAU could be a safe agent to mitigate cirrhosis-induced erythrocyte damage and anemia. Further investigations are necessary to prove this in clinical settings.

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Taurine amino acid supplementation impacts performance, blood hematology, oxidative stress, and jejunum morphology in broiler chickens

Sandoghdar,

Irani,

Gharahveysi

2024

Trop Anim Health Prod

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Cytoprotective effect of taurine against sodium chlorate-induced oxidative damage in human red blood cells: an ex vivo study

Cited by 10 publications

References 80 publications

Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain

Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain

Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

Taurine amino acid supplementation impacts performance, blood hematology, oxidative stress, and jejunum morphology in broiler chickens

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