Cytoprotective effects of cinnamaldehyde and adipoRon against cyclophosphamide‐induced cardio-renal toxicity in rats: Insights into oxidative stress, inflammation, and apoptosis

Abd El Salam, Al Shaima G.; Samaha, Mahmoud M.; Abd Elrazik, Nesma A.

doi:10.1016/j.intimp.2023.111044

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…CA is widely acknowledged for its exceptional safety profile, and research advancements indicate that CA possesses the ability to mitigate the toxic side effects of chemotherapy drugs ( 99 , 100 ). Specifically, CA has demonstrated a capacity to alleviate cardiotoxicity induced by DOX ( 99 ), and exhibits cytoprotective effects, safeguarding against cardiorenal toxicity triggered by cyclophosphamide ( 100 ).…”

Section: Safety Of Camentioning

confidence: 99%

Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)

Han,

Li,

Gao

et al. 2024

Mol Med Rep

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Cancer incidence is increasing globally, presenting a growing public health challenge. While anticancer drugs are crucial in treatment, their limitations, including poor targeting ability and high toxicity, hinder effectiveness and patient safety, requiring relentless scientific research and technological advancements to develop safer and more effective therapeutics. Cinnamaldehyde (CA), an active compound derived from the natural plant cinnamon, has garnered attention in pharmacological research due to its diverse therapeutic applications. CA has potential in treating a wide array of conditions, including cardiovascular diseases, diabetes, inflammatory disorders and various forms of cancer. The present review comprehensively summarizes the physicochemical and pharmacokinetic profiles of CA, and delves into the latest advancements in elucidating its potential mechanisms and targets across various cancer types. CA and its derivatives have antitumor effects, which encompass inhibiting cell proliferation, arresting the cell cycle, inducing apoptosis, limiting cell migration and invasion, and suppressing angiogenesis. Additionally, the present review explores targeted formulations of CA, laying a scientific foundation for further exploration of its implications in cancer prevention and treatment strategies.

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