Cytoprotective Effects of Natural Highly Bio-Available Vegetable Derivatives on Human-Derived Retinal Cells

Munia, I; Gafray, L; Bringer, Marie-Agnès; Goldschmidt, Paul; Proukhnitzky, L; Jacquemot, Nathalie; Cercy, C.; K, Ramchani Ben Otman; Errera, Marie‐Hélène; Ranchon-Cole, Isabelle

doi:10.3390/nu12030879

Cited by 14 publications

(20 citation statements)

References 71 publications

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“…Instead, only a few studies focused on the effects of lutein/ zeaxanthin on cell-clearing systems. Indeed, lutein, through autophagy induction, protects human RPE cells from cell death induced by either chronic oxidative stress, staurosporine, or LED light exposure [ 57 ]. This is also correlated with a reduction in basal-VEGF release [ 57 ].…”

Section: Lutein Resveratrol and Vaccinium Myrtillus mentioning

confidence: 99%

“…Indeed, lutein, through autophagy induction, protects human RPE cells from cell death induced by either chronic oxidative stress, staurosporine, or LED light exposure [ 57 ]. This is also correlated with a reduction in basal-VEGF release [ 57 ]. Again, lutein, through induction of autophagy, mitigates the cytotoxic effects of vital dyes indocyanine green (ICG) and brilliant blue G in human RPE cells [ 196 ].…”

Section: Lutein Resveratrol and Vaccinium Myrtillus mentioning

confidence: 99%

“…In general, these compounds have been claimed to interfere with the biology of disease by mitigating oxidative stress and inflammation, which play a critical role in the initiation and progression of AMD [ 47 , 53 , 54 , 55 , 56 ]. However, some pieces of evidence suggest that, besides oxidative stress and inflammation, the beneficial effects of these phytochemicals may be explained by a potential involvement in cell-clearing system alterations within RPE, which were briefly summarized so far as candidate pathogenic events to produce retinal damage in AMD [ 56 , 57 , 58 , 59 , 60 ]. Thus, a synergism between these compounds may extend to cell clearing pathways, which play a fundamental role in tuning the orchestration at the retinal-choroid border, where RPE cells may be the pivot.…”

Section: Introductionmentioning

confidence: 99%

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A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals

Pinelli

Biagioni

Limanaqi

et al. 2020

IJMS

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Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for dry and wet variants, or do they stem from common metabolic alterations? Where shall we look for altered metabolism? Is it the inner choroid, or is it rather the choroid–retinal border? Again, since cell-clearing pathways are crucial to degrade altered proteins, which metabolic system is likely to be the most implicated, and in which cell type? Here we describe the unique clearing activity of the retinal pigment epithelium (RPE) and the relevant role of its autophagy machinery in removing altered debris, thus centering the RPE in the pathogenesis of AMD. The cell-clearing systems within the RPE may act as a kernel to regulate the redox homeostasis and the traffic of multiple proteins and organelles toward either the choroid border or the outer segments of photoreceptors. This is expected to cope with the polarity of various domains within RPE cells, with each one owning a specific metabolic activity. A defective clearance machinery may trigger unconventional solutions to avoid intracellular substrates’ accumulation through unconventional secretions. These components may be deposited between the RPE and Bruch’s membrane, thus generating the drusen, which remains the classic hallmark of AMD. These deposits may rather represent a witness of an abnormal RPE metabolism than a real pathogenic component. The empowerment of cell clearance, antioxidant, anti-inflammatory, and anti-angiogenic activity of the RPE by specific phytochemicals is here discussed.

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Section: Lutein Resveratrol and Vaccinium Myrtillus mentioning

confidence: 99%

Section: Lutein Resveratrol and Vaccinium Myrtillus mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals

Pinelli

Biagioni

Limanaqi

et al. 2020

IJMS

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“…Along this line, LUT exhibited a protective role in human retinal pigment epithelial cells (ARPE-19 cells) exposed to different stimuli implicated in agerelated macular degeneration pathogenesis (AMD), a severe disease that causes vision loss. The mechanisms underlying these actions were associated with an inhibition of apoptosis, VEGF levels, and oxidative stress markers, as well as prevention of autophagy flux alteration [151]. Similarly, a LUT nanoemulsion improved penetration into ARPE-19 cells and protected cells from H 2 O 2 -induced damage [152].…”

Section: Lutein 421 In Vitro Studiesmentioning

confidence: 99%

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

et al. 2021

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as α- and β-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, α- and β-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

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“…Munia et al evaluated the effects of resveratrol, lutein and curcumin on human retinal epithelial cells, demonstrating that these cells, after an oxidative stress insult, were protected from death by a pre-treatment with these nutraceutical compounds. 47 …”

Section: Curcumin and Retinal Diseasesmentioning

confidence: 99%

Recent Advances and Disputes About Curcumin in Retinal Diseases

Nebbioso¹,

Franzone²,

Greco³

et al. 2021

OPTH

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Curcumin belongs to the group of so-called phytocompounds, biologically active molecules produced by plants exerting a beneficial effect on health. Curcumin shows a wide spectrum of different properties, being an anti-inflammatory, antioxidant, antimicrobial and antimutagenic molecule. The purpose of the review is to examine what literature reported on the characteristics of curcumin, particularly, on the beneficial and controversial aspects of this molecule, aiming for a better therapeutic management of retinal diseases. The retina is a constant target of oxidative stress, this tissue being characterized by cells rich in mitochondria and by vessels and being, obviously, continuously reached from photons affecting its layers. Particularly, the retinal ganglion cells and the photoreceptors are extremely sensitive to oxidative stress damage and it is well known that an imbalance in reactive oxygen species is often involved in several retinal diseases, such as uveitis, age-related macular degeneration, diabetic retinopathy, central serous chorioretinopathy, macular edema, retinal ischemia-reperfusion injury, proliferative vitreoretinopathy, hereditary tapeto-retinal degenerations, and retinal and choroidal tumors. To date, several studies suggest that oral treatment with curcumin is generally well tolerated in humans and, in addition, it seems to have no negative effects: therefore, curcumin is a promising candidate as a retinal disease therapy. Unfortunately, the primary limitation of curcumin is represented by its poor bioavailability, in fact only a minimal fraction of this substance can reach the blood stream in the form of a biologically active compound. However, many steps have been made in several fields. In the future, it is expected that the strategies developed until now to allow curcumin to reach the target tissues in adequate concentrations could be ameliorated and, above all, large in vivo studies on humans are needed to demonstrate the total safety of these compounds and their effectiveness in different eye diseases.

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Cytoprotective Effects of Natural Highly Bio-Available Vegetable Derivatives on Human-Derived Retinal Cells

Cited by 14 publications

References 71 publications

A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals

A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

Recent Advances and Disputes About Curcumin in Retinal Diseases

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