Cytoreductive surgery plus intraperitoneal hyperthermic perfusion is an effective treatment for metastasized malignant mixed mesodermal tumours (MMMT)—report of six cases

Müller, H; Nakchbandi, V

doi:10.1016/j.ejso.2004.02.002

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…Various chemotherapeutic agents have been tried in the past. Platinum-based chemotherapy and ifosfamide were found to be superior to doxorubin for treatment of uterine carcinosarcomas [45, 46]. The combination was also found to be superior to ifosfamide alone for advanced, persistent, or recurrent disease [47, 48].…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

Kapur

Levin

2014

Case Reports in Oncological Medicine

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We report a case of a 53-year-old female who presented with chronic constipation and abdominal discomfort for six months. Her past surgical history was significant for a total abdominal hysterectomy with bilateral salpingooophorectomy, performed eight years ago, for uterine fibroids and endometriosis. Workup revealed a mass measuring 5 × 4.5 × 2 cm in the rectosigmoid colon. Patient underwent a low anterior resection and a fungating, centrally ulcerated rectosigmoid mass with a positive mesorectal margin was removed. Histopathology revealed a heterologous mixed mesodermal tumor (chondroid and osteoid elements). The epithelial component was compatible with a grade 2 endometrioid adenocarcinoma. Immunohistochemical stains were supportive, with positive expression for CK7 and ER, negative for CK20, and only very focally and weakly positive for both CDX2 and p63. Chromogranin, synaptophysin, and TTF-1 were negative. Following surgery, she was treated with five cycles of carboplatin (AUC 6) and paclitaxel (175 mg/m2), followed by irradiation. Twenty-six months later, patient continues to be asymptomatic and disease-free. Mixed müllerian mesodermal tumors mimicking colorectal cancer have been reported in the past. Our case highlights the rarity and the challenges encountered in diagnosing and treating these rare tumors.

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Section: Discussionmentioning

confidence: 99%

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

Kapur

Levin

2014

Case Reports in Oncological Medicine

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“…Conversely, other authors consider that extragenital MMMT is one kind of PPC and is similar to ovarian epithelial tumor. Muller et al reported six cases of metastasized MMMTs receiving cytoreductive surgery plus intraperitoneal hyperthermic perfusion and adjuvant treatment of CDDP (cis-diamminedichloroplatinum), mitomycin and ifosfamide applied via intraaortic catheter [10]. Four patients were found with no evidence of disease after two, four, 14, and 19 months, respectively.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant mixed Müllerian tumor arising from the mesorectum with a synchronous ovarian cancer: a case report and review of the literature

Huang

et al. 2011

J Med Case Reports

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IntroductionExtragenital malignant mixed Müllerian tumor is an extremely rare presentation of malignant mixed Müllerian tumor, especially when combined with a synchronous ovarian cancer.Case presentationWe report the clinical course and pathologic findings of a case of mesorectal malignant mixed Müllerian tumor with synchronous ovarian cancer, in a 50-year-old, gravida 0, para 0, Han Chinese woman with regular menstruation. This is the sixteenth case in the English literature of extragenital malignant mixed Müllerian tumor combined with synchronous or metachronous malignancy reported.ConclusionAlthough extragenital malignant mixed Müllerian tumor is very rare and has a poor prognososis, a longer survival time might be achieved with treatment by cytoreductive surgery, radiotherapy and chemotherapy.

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“…The prognosis of ovarian carcinosarcoma is dependent on the residual tumor [1] . Complete cytoreduction with no macroscopically visible residual tumor is the fi rst step of the treatment.…”

Section: Discussionmentioning

confidence: 99%

“…They are usually associated with peritoneal spread and ascites at the time of initial diagnosis [1] . A few patients with advanced disease have been reported as longterm survivors.…”

Section: Introductionmentioning

confidence: 99%

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Complete Cytoreduction Combined with Early Postoperative Intraperitoneal Chemotherapy for Ovarian Carcinosarcoma

Xanthoulis¹,

Mirelis²,

Markakidis³

et al. 2006

Gynecol Obstet Invest

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Background/Aims: The purpose of the study is to report two long-term survivors with ovarian carcinosarcomas, which are rare intrapelvic malignancies with unfavorable prognosis. Methods: Two middle-aged women with palpable abdominal tumors underwent complete cytoreductive surgery and no macroscopic tumor was left behind. Early postoperative intraperitoneal chemotherapy with doxorubicin was used as an adjuvant treatment. Results: The patients are disease-free 2 and 3 years, respectively after the initial therapy. Conclusion: Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy seems to be an effective treatment for ovarian carcinosarcoma with peritoneal spread. Further studies are required to define the value of intraperitoneal chemotherapy in ovarian carcinosarcoma.

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Cytoreductive surgery plus intraperitoneal hyperthermic perfusion is an effective treatment for metastasized malignant mixed mesodermal tumours (MMMT)—report of six cases

Cited by 8 publications

References 21 publications

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

Primary malignant mixed Müllerian tumor arising from the mesorectum with a synchronous ovarian cancer: a case report and review of the literature

Complete Cytoreduction Combined with Early Postoperative Intraperitoneal Chemotherapy for Ovarian Carcinosarcoma

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