Cytoskeletal crosstalk: when three different personalities team up

Huber, Florian; Boire, Adeline; López, Magdalena Preciado; Koenderink, Gijsje H.

doi:10.1016/j.ceb.2014.10.005

Cited by 247 publications

(276 citation statements)

References 75 publications

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“…These events suggest a compromised astroglial defense system that is probably playing a role in the physiopathology of the neurological dysfunction of hypothyroidism (Figure 3). Despite the focus on the misregulation of IF dynamics in response to signaling mechanisms downstream of metabolites and neurotoxicants, we should consider that cytoskeleton is a complex meshwork of interconnecting filaments [1]. In this regard, the morphological alterations demonstrated in primary cells in culture mainly reflect the reorganization of the meshwork of filaments.…”

Section: Hypothyroidism and The Cytoskeleton Of Neural Cellmentioning

confidence: 99%

Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity

Zamoner¹,

Pessoa-Pureur²

2017

Cytoskeleton - Structure, Dynamics, Function and Disease

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In this chapter, we deal with the current knowledge and important results on the cytoskeletal proteins and their differential regulation by kinases/phosphatases and Ca 2+mediated mechanisms in developmental rat brain. We focus on the misregulation of the phosphorylating system associated with intermediate filament proteins of neural cells and its relevance to cell and tissue dysfunction. Taking into account our findings, we propose that intermediate-filament proteins are dynamic structures whose regulation is crucial for proper neural cell function. Given their relevance, they must be regulated in response to extracellular and intracellular signals. The complexity and connection between signaling pathways regulating intermediate-filament dynamics remain obscure. In this chapter, we get light into some kinase/phosphatase cascades downstream of membrane receptors disrupting the dynamics of intermediate filaments and its association with neural dysfunction. However, intermediate filaments do not act individually into the neural cells. Our results evidence the importance of misregulated cytoskeletal crosstalk in disrupting cytoskeletal dynamics and cell morphology underlying neural dysfunction in experimental conditions mimicking metabolic diseases and nongenomic actions of thyroid hormones and as an end point in the neurotoxicity of organic tellurium.

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Section: Hypothyroidism and The Cytoskeleton Of Neural Cellmentioning

confidence: 99%

Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity

Zamoner¹,

Pessoa-Pureur²

2017

Cytoskeleton - Structure, Dynamics, Function and Disease

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“…1.3, and interact directly with molecular motors (e.g. myosin or kinesin) [97]. IFs are non-polar, due to the anti-parallel assembly step of dimers into tetramers (see section 1.4.1 for more details) and are negatively charged.…”

Section: The Cytoskeletonmentioning

confidence: 99%

“…The cytoskeleton of eukaryotic cells is composed of three main structures [97]: i) the microfilaments made out of actin, having a diameter of 7 to 8 nm [60], ii) the microtubules made out of tubulin, which are hollow tubes with a diameter of 25 nm [98], and iii) the intermediate filaments (IFs) made out of various proteins, having a diameter of 10 nm [99,100]. Each of these three distinct structures have different roles in the cells.…”

Section: The Cytoskeletonmentioning

confidence: 99%

Investigating Cellular Nanoscale with X-rays

Hémonnot¹

2016

Göttingen Series in X-Ray Physics

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“…Given the crosstalk existing between each constituent of the cytoskeleton which yields its dynamic properties, 73 it is necessary to isolate and reconstitute individual components in order to determine their properties and role in global cell behavior. The cytoskeletal protein actin has many functions including in cell mechanical stability, motility, division and shape.…”

Section: Investigation Of In-vitro Cytoskeletal Constituentsmentioning

confidence: 99%

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

Denning

Roos

2016

Cell Adhesion & Migration

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The use of synthetic surfaces and materials to influence and study cell behavior has vastly progressed our understanding of the underlying molecular mechanisms involved in cellular response to physicochemical and biophysical cues. Reconstituting cytoskeletal proteins and interfacing them with a defined microenvironment has also garnered deep insight into the engineering mechanisms existing within the cell. This review presents recent experimental findings on the influence of several parameters of the extracellular environment on cell behavior and fate, such as substrate topography, stiffness, chemistry and charge. In addition, the use of synthetic environments to measure physical properties of the reconstituted cytoskeleton and their interaction with intracellular proteins such as molecular motors is discussed, which is relevant for understanding cell migration, division and structural integrity, as well as intracellular transport. Insight is provided regarding the next steps to be taken in this interdisciplinary field, in order to achieve the global aim of artificially directing cellular response.

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Cytoskeletal crosstalk: when three different personalities team up

Cited by 247 publications

References 75 publications

Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity

Intermediate Filaments as a Target of Signaling Mechanisms in Neurotoxicity

Investigating Cellular Nanoscale with X-rays

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

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