2024
DOI: 10.3390/cells13100865
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Cytosolic and Acrosomal pH Regulation in Mammalian Sperm

Julio C. Chávez,
Gabriela Carrasquel-Martínez,
Sandra Hernández-Garduño
et al.

Abstract: As in most cells, intracellular pH regulation is fundamental for sperm physiology. Key sperm functions like swimming, maturation, and a unique exocytotic process, the acrosome reaction, necessary for gamete fusion, are deeply influenced by pH. Sperm pH regulation, both intracellularly and within organelles such as the acrosome, requires a coordinated interplay of various transporters and channels, ensuring that this cell is primed for fertilization. Consistent with the pivotal importance of pH regulation in ma… Show more

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