Cytosporones and Related Compounds, A Review: Isolation, Biosynthesis, Synthesis and Biological Activity of Promising Fungal Resorcinolic Lipids

Synthesis and Biological Activity of Octaketides from the Cytosporone Family

“…All the compounds exhibit cytotoxicity against A549 and 786‐O cancer cell‐lines as well as mitochondrial toxicity with IC 50 >10 μM (Figure ), indicating that they exhibit an acceptable profile with regards to these assays . These observations are also in accord with those previously reported ,,,…”

“…The authors reported potent antibiotic activity for triols cytosporone D and E, while diols cytosporone A, B and C showed no significant antibacterial activity. Since then, a range of structurally related natural products (cytosporones, dothiorelones and phomopsins) was isolated and an increasing number of syntheses have been reported…”

Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB

“…Octaketide resorcinolic lipids named cytosporones have attracted a great deal of interest from many researchers. They exhibit notable biological potential, comprising fungicidal, allelopathic, bactericidal, and cytotoxic activities (Meza et al 2015). Recently, novel, structurally similar octaketides have been isolated and a few approaches for the synthesis of these molecules were reported (Meza et al 2015, Cochrane et al 2016, Zamberlam et al 2012, Dos Santos et al 2009, Zhenga et al 2019, Dos Santos et al 2020.…”

“…They exhibit notable biological potential, comprising fungicidal, allelopathic, bactericidal, and cytotoxic activities (Meza et al 2015). Recently, novel, structurally similar octaketides have been isolated and a few approaches for the synthesis of these molecules were reported (Meza et al 2015, Cochrane et al 2016, Zamberlam et al 2012, Dos Santos et al 2009, Zhenga et al 2019, Dos Santos et al 2020. These findings also revealed that cytosporones are potentially pharmaceutical and agrochemical agents (Meza et al 2015, von Delius et al 2017.…”

“…Recently, novel, structurally similar octaketides have been isolated and a few approaches for the synthesis of these molecules were reported (Meza et al 2015, Cochrane et al 2016, Zamberlam et al 2012, Dos Santos et al 2009, Zhenga et al 2019, Dos Santos et al 2020. These findings also revealed that cytosporones are potentially pharmaceutical and agrochemical agents (Meza et al 2015, von Delius et al 2017. The most representative compounds in this class of resorcinolic lipids are cytosporones A-E (1-5, Figure 1), isolated from the endophytic fungi Cytospora sp.…”