Cytotoxic Action of Acetyl-11-keto-β-Boswellic Acid (AKBA) on Meningioma Cells

Park, Yong Seok; Lee, Joung H.; Bondar, Judy; Harwalkar, Jyoti A.; Safayhi, H.; Golubić, Mladen

doi:10.1055/s-2002-32090

Cited by 73 publications

(48 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Along these lines, AKBA antagonized TNFα-induced phosphorylation of PKB/Akt and p38 MAPK in human myeloid KBM-7 cells [76]. On the other hand, AKBA (IC 50 = 15 µM) even prevented ERK1/2 phosphorylation and cell motility in PDGF-primed meningioma cells [77]. Since the Ras-ERK route transmits survival signals in tumorigenic cells [78], ERK inhibition could at least partly explain the anti-proliferative effects of AKBA observed in this study [79].…”

Section: Intracellular Signaling Networkmentioning

confidence: 93%

Boswellic Acids: Biological Actions and Molecular Targets

Poeckel¹,

Werz

2006

CMC

206

153

View full text Add to dashboard Cite

Gum resin extracts of Boswellia species have been traditionally applied in folk medicine for centuries to treat various chronic inflammatory diseases, and experimental data from animal models and studies with human subjects confirmed the potential of B. spec extracts for the treatment of not only inflammation but also of cancer. Analysis of the ingredients of these extracts revealed that the pentacyclic triterpenes boswellic acids (BAs) possess biological activities and appear to be responsible for the respective pharmacological actions. Approaches in order to elucidate the molecular mechanisms underlying the biological effects of BAs identified 5-lipoxygenase, human leukocyte elastase, toposiomerase I and II, as well as IkappaB kinases as molecular targets of BAs. Moreover, it was shown that depending on the cell type and the structure of the BAs, the compounds differentially interfere with signal transduction pathways including Ca(2+/-) and MAPK signaling in various blood cells, related to functional cellular processes important for inflammatory reactions and tumor growth. This review summarizes the biological actions of BAs on the cellular and molecular level and attempts to put the data into perspective of the beneficial effects manifested in animal studies and trials with human subjects related to inflammation and cancer.

show abstract

Section: Intracellular Signaling Networkmentioning

confidence: 93%

Boswellic Acids: Biological Actions and Molecular Targets

Poeckel¹,

Werz

2006

CMC

206

153

View full text Add to dashboard Cite

show abstract

“…1-6) These acids have also been shown to possess potential chemopreventive effects, e.g., these inhibited growth of brain tumor 7) and meningioma cells, 8) and induced apoptosis in human leukemia 9) and hepatoma cells. 10) In view of the pharmacological importance of the natural compounds derived from Boswellia resin, 1,6) we were especially interested to undertake investigation on the constituents of Boswellia resin in order to evaluate their further pharmacological potentials.…”

Section: )mentioning

confidence: 99%

Cancer Chemopreventive Effects and Cytotoxic Activities of the Triterpene Acids from the Resin of Boswellia carteri

Akihisa

Tabata

Banno

et al. 2006

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The Boswellia species (Burseraceae), which are trees native to Ethiopia, Somalia, India, and the Arabic peninsula, produce a gum resin that is known as olibanum (frankincense). The resin of B. carteri and B. serrata has been used for the treatment of rheumatoid arthritis and other inflammatory diseases in the traditional medicine in many countries. 1)The search for the active principles of the resin resulted in the isolation of boswellic acids that belong to ursane-and oleanane-type pentacyclic triterpenes.1-6) These acids have also been shown to possess potential chemopreventive effects, e.g., these inhibited growth of brain tumor 7) and meningioma cells, 8) and induced apoptosis in human leukemia 9) and hepatoma cells. 10) In view of the pharmacological importance of the natural compounds derived from Boswellia resin, 1,6) we were especially interested to undertake investigation on the constituents of Boswellia resin in order to evaluate their further pharmacological potentials. In our recent paper, 11) we have reported the isolation and identification of fifteen triterpene acids (1-14, 16) and two diterpenes (17, 18) from the MeOH extract of the resin of B. carteri along with the evaluation of the inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice of compounds 1-14, 16-18, and 15 (the acetyl derivative of 14). This paper describes the inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by TPA in Raji cells and on activation of (Ϯ)-(E)-methyl-2[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitrogen oxide (NO) donor, and cytotoxic activities against three human neuroblastoma cell lines, IMR-32, NB-39, and SK-N-SH in vitro for compounds 1-18. MATERIALS AND METHODS Materials and ChemicalsThe olibanum resin with certified botanical origin, Boswellia carteri Birdwood (Somalia), was purchased from Scents of Earth (Sun City, CA, U.S.A.; http://www.scents-of-earth.com).11) Chemicals were purchased as follows: TPA from ChemSyn Laboratories (Lenexa, KS, U.S.A.), b-carotene, glyzyrrhizin, and cisplatin (CDDP) from Sigma Chemical Co. (St. Louis, MO, U.S.A.), the EBV cell culture reagents and n-butanoic acid from Nacalai Tesque, Inc. (Kyoto, Japan), and NOR 1 and carboxy-PTIO from Dojindo Laboratories (Kumamoto, Japan). Three human neuroblastoma cell lines, IMR-32, NB-39, and SK-N-SH, were maintained in RPMI-1640 medium (Invitrogen) supplemented with 100 U/ml penicillin, 100 mg/ml streptomycin, and 10% fetal bovine serum (FBS) (Invitrogen). All of them were maintained at 37°C/5% CO 2 in a humid environment.Extraction and Isolation Extraction of the resin of B. carteri and isolation of compounds 1-18 from the extract was described in our recent paper.11) In brief, the pulverized resin of B. carteri (10 g) was extracted with MeOH to yield extract (8.95 g). The extract was suspended in n-hexaneMeOH-H 2 O (19 : 19 : 2), giving n-hexane (5.05 g) and MeOH-H 2 O fractions. The latter fraction was partitioned in EtOAc-H 2 O (1 : 1, v/v), yielding E...

show abstract

“…In addition to these antiinflammatory indications, BAs have been reported to negatively influence the growth and differentiation of tumor cells, causing chemo-preventive effects [6]. Thus, BAs induce apoptosis of brain tumor cell lines [7], meningioma cells [8], rat gliomas [9], liver and colon cancer cell lines [10], and leukemia cells [11]. Caspase-8 [10], topoisomerases [11], and the p42/44 mitogen activated protein kinase (MAPK) pathway [8] have been suggested as intermediate molecules for the apoptotic effects of BAs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats

et al. 2011

View full text Add to dashboard Cite

Time-dependent effects of ethanolic extract of Boswellia papyrifera, administered systemically, on spatial memory retention in the Morris water maze were investigated in male rats. A total extract of Boswellia papyrifera (300 mg/kg) was administered every eight hours to three groups of rats by gavage for 1, 2 and 4 weeks. In a separate set of experiments, three doses of a fraction of the extract, called the boswellic acids (100, 200 and 300 mg/kg) were administered by gavage to three groups of rats three times a day for 2 weeks. Following these applications, animals were trained for 4 days. Behavioral testing for evaluation of spatial memory retention was performed 48 h after completion of training. Boswellia papyrifera extracts and boswellic acids caused a significant reduction in escape latency and distance traveled but had no influence on swimming speed. These findings provide evidence that Boswellia papyrifera extracts affect spatial memory retention irrespective of the treatment period. In addition our data show that systemic administration of the boswellic acids fraction enhanced spatial memory retention in a dose-dependent manner. These improving effects may be due to some extent to the interactions of these products with inflammatory mediators, neurotransmitter signaling cascades or protein kinase pathways in the brain.

show abstract

Cytotoxic Action of Acetyl-11-keto-β-Boswellic Acid (AKBA) on Meningioma Cells

Cited by 73 publications

References 13 publications

Boswellic Acids: Biological Actions and Molecular Targets

Boswellic Acids: Biological Actions and Molecular Targets

Cancer Chemopreventive Effects and Cytotoxic Activities of the Triterpene Acids from the Resin of Boswellia carteri

Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats

Contact Info

Product

Resources

About