Cytotoxic action of bisabololoxide A of German chamomile on human leukemia K562 cells in combination with 5-fluorouracil

Ogata-Ikeda, Ikuko; Seo, Hakaru; Kawanai, Takuya; Hashimoto, Erika; Oyama, Yasuo

doi:10.1016/j.phymed.2010.08.007

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…The incubation of rat thymocytes with 30–100 μM BSBO for 24 h was shown to increase the population of shrunken cells and phosphatidylserine‐exposed cells (Ogata et al ., ). No cytotoxic action was observed with 3 μM BSBO in rat thymocytes and human leukemia K562 cells after 24 h of incubation (Ogata et al ., , Ogata‐Ikeda et al ., ). However, 3 μM BSBO attenuated the A23187‐induced cell shrinkage and externalization of phosphatidylserine when cells were incubated with A23187, BSBO, or both for 3 h (Figs.…”

Section: Discussionmentioning

confidence: 97%

“…(Ogata et al, 2010). No cytotoxic action was observed with 3 μM BSBO in rat thymocytes and human leukemia K562 cells after 24 h of incubation (Ogata et al, 2010, Ogata-Ikeda et al, 2011. However, 3 μM BSBO attenuated the A23187-induced cell shrinkage and externalization of phosphatidylserine when cells were incubated with A23187, BSBO, or both for 3 h (Figs.…”

Section: Reciprocal Effects Of Bsbomentioning

confidence: 90%

“…The incubation time with A23187 was set to be 3 h. BSBO was added to cell suspension just before the application of A23187. The effect of BSBO at 10 μM or lower was mainly examined in this study because BSBO at 30-100 μM exerted cytotoxic actions on rat thymocytes when the incubation time was 24 h (Ogata-Ikeda et al, 2011). In the experiment using Z-VAD-FMK, the agent was added into cell suspension just before the application of A23187, BSBO, or their combination.…”

Section: Methodsmentioning

confidence: 99%

“…The cytoprotective effect of 30 μM BSBO was similar to that of 10 μM BSBO (not shown). BSBO at high micromolar concentrations may exert both cytoprotective action against calcium overload and cytotoxic action (Ogata-Ikeda et al, 2011).…”

Section: Effect Of Bsbo On A23187-induced Increase In Cell Lethalitymentioning

confidence: 99%

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Bisabololoxide A, One of the Constituents in German Chamomile Extract, Attenuates Cell Death Induced by Calcium Overload

et al. 2013

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Bisabololoxide A (BSBO), main constituents in German chamomile extract, is responsible for antipruritic effect. In previous study, the incubation with 30-100 μM BSBO for 24 h exerted cytotoxic and proapoptotic effects on rat thymocytes. To further characterize BSBO cytotoxicity, the effect on the cells suffering from calcium overload by calcium ionophore A23187 was examined. A23187 induced Ca(2+) -dependent cell death. Contrary to our expectation, 1-10 μM BSBO inhibited A23187-induced increase in cell lethality of rat thymocytes. BSBO attenuated A23187-induced increases in populations of shrunken living cells, phosphatidylserine-exposed living cells, and dead cells, without affecting the increase in intracellular Ca(2+) concentration and the Ca(2+) -dependent hyperpolarization. The effect of BSBO on A23187-treated cells may be unique because the activation of Ca(2+) -dependent K(+) channels is required for cell shrinkage, externalization of phosphatidylserine, and cell death in some cells. The cell death induced by A23187 was not inhibited by Z-VAD-FMK, a pan-inhibitor of caspases. Thus, the cell death may be a necrosis with some features observed during an early stage of apoptosis. These results suggest that BSBO at low micromolar concentrations is cytoprotective against calcium overload.

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Section: Discussionmentioning

confidence: 97%

Section: Reciprocal Effects Of Bsbomentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Effect Of Bsbo On A23187-induced Increase In Cell Lethalitymentioning

confidence: 99%

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Bisabololoxide A, One of the Constituents in German Chamomile Extract, Attenuates Cell Death Induced by Calcium Overload

et al. 2013

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“…The antioxidant characteristics of chamomile are associated with reducing lipid oxidation (Guimarães et al, 2013;Rekka, Kourounakis, & Kourounakis, 1996) and may influence consequences of peroxidation such as atherosclerosis. Additionally, apigenin glucosides and alpha-bisbolol found in chamomile have shown potential in inducing apoptosis in cancer cells (Cavalieri et al, 2004;Kassi et al, 2004;Ogata-Ikeda, Seo, Kawanai, Hashimoto, & Oyama, 2011;Srivastava & Gupta, 2007). Few human studies (especially prospective studies and clinical trials) exist on longterm effects of chamomile on health outcomes.…”

Section: Health Benefits Of Chamomilementioning

confidence: 99%

Chamomile Consumption and Mortality: A Prospective Study of Mexican Origin Older Adults

Howrey

Peek

McKee

et al. 2015

GERONT

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Purpose: Approximately 20% of adults use some kind of herbal; however, little data exists from population-based study or clinical trials to support effectiveness of most herbal products. Chamomile is a commonly used herb among older adults of Mexican origin. We examined the effects of herbal chamomile consumption on mortality among older adults of Mexican origin. Methods and Design: A sample from the Hispanic Established Populations for Epidemiologic Study of the Elderly, a population-based study of noninstitutionalized Mexican Americans aged 65 and older from five Southwestern states (Texas, California, New Mexico, Colorado, and Arizona). We included all men and women from 2000 to 2007 (n = 1,677). Results: Chamomile was used by 14% of the sample. Cox proportional hazards regression analyses showed that chamomile was associated with a decreased risk of mortality in the total sample (hazard ratio [HR] 0.71, 95% confidence interval [CI] 0.55-0.92) and for women (HR 0.67, 95% CI 0.49-0.92) but not for men. In models adjusted for sociodemographic variables, health behaviors, and chronic conditions, chamomile remained significantly associated with reduced mortality in women (HR 0.72,. Implications: The use of chamomile shows protective effects against mortality in this sample of older adults of Mexican origin for women. Further research is warranted in other populations to determine if these effects are consistent.

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Matricaria chamomilla

Lim¹

2013

Edible Medicinal and Non-Medicinal Plants

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Cytotoxic action of bisabololoxide A of German chamomile on human leukemia K562 cells in combination with 5-fluorouracil

Cited by 11 publications

References 18 publications

Bisabololoxide A, One of the Constituents in German Chamomile Extract, Attenuates Cell Death Induced by Calcium Overload

Bisabololoxide A, One of the Constituents in German Chamomile Extract, Attenuates Cell Death Induced by Calcium Overload

Chamomile Consumption and Mortality: A Prospective Study of Mexican Origin Older Adults

Matricaria chamomilla

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