Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines

Andania, Meiridha Mutiara; Ismed, Friardi; Taher, Muhammad; Ichwan, Solachuddin Jauhari Arief; Bakhtiar, Amri; Аrbаin, Dаyаr

doi:10.5614/j.math.fund.sci.2019.51.3.2

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…To the increasing quality of the active fraction, then the total extract compound was separated and purified by both chromatography and recrystallization techniques to obtain a pure active compound which has cytotoxicity activity. 14 In order that we also carried out identification compounds using UV-Vis.…”

Section: The Fraction Of Extract Compoundmentioning

confidence: 99%

POTENTIAL TRACKING OF CYTOTOXIC ACTIVITIES OF MANGROVE PEREPATE (Sonneratia alba) ROOT EXTRACT AS AN ANTICANCER CANDIDATE

Latief

Nelson

Amanda

et al. 2020

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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Mangrove plants are one of the most extensive biodiversity in Jambi. Besides functioning as a coastal ecosystem protector, it also has any potential of its chemical content. The study of mangrove’s bioactive compound is important to generate a new therapeutic agent. This study aims to obtain chemical compounds that have cytotoxic activity, reveal the chemical formula and molecular structure of that active compound, and determine the cytotoxic activity level of active compound from perepat (Sonneratia alba) root extract. The extract was isolated and purified using Liquid Vacuum Chromatography, Graphitation Column Chromatography, and Thin Layer Chromatography. The isolate was characterized using FT-IR spectrophotometry. Our result found that it corresponds to the β-sitosterol compound group with a high similarly chromophore. Furthermore, both of the extract and isolate was tested for toxicity activity using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina shrimp larvae. Herein, we reported that acetone isolated extract possesses lower cell death average 100% (start 200 μg/ml) than isolate extract 80% (50μg/ml). Furthermore the toxicity of total extract has LC50 23,98 (μg/ml), while Isolate 10,04 (μg/ml). From the LC50 value, it can be concluded that the toxicity of the extract lower than the isolate, and both were classified as very toxic compounds, and very potential to be developed into anti-cancer drug compounds.

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Section: The Fraction Of Extract Compoundmentioning

confidence: 99%

POTENTIAL TRACKING OF CYTOTOXIC ACTIVITIES OF MANGROVE PEREPATE (Sonneratia alba) ROOT EXTRACT AS AN ANTICANCER CANDIDATE

Latief

Nelson

Amanda

et al. 2020

Pharmacology and Clinical Pharmacy Research (PCPR) is an intern

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“…In line with ongoing research on Sumatran medicinal plants and the search for alternative medicines [18][19][20], corn cobs are reported to have the potential for anti-tyrosinase and antiaging (through inhibition of elastase and hyaluronidase enzymes). The evaluation method is based on in vitro inhibiting enzyme action (tyrosinase, elastase, and hyaluronidase).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Anti-Tyrosinase-Anti-Aging Potential and Metabolite Profiling From the Bioactive Fraction of Corn Cob (Zea Mays L.)

HARAHAP,

TRIAMARTA,

KHARISMA

et al. 2024

Int J App Pharm

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Objective: Maize (Zea mays L.) is a crop that has been widely cultivated in Indonesia. Using corn kernels on a large scale will produce much corn cob waste, usually unused. According to the literature search, corn cobs’ phytochemical studies and pharmacological activities still need to be improved. This study aims to determine the content of secondary metabolites (metabolite profiling) and their antityrosinase and anti-aging potential. Methods: Corn cobs were macerated with methanol and fractionated with n-hexane, ethyl acetate, and butanol. The phytochemical profiling approach of the methanol extract was performed by liquid chromatography-mass spectra (LC-MS/MS). Anti-tyrosinase and anti-aging bioactivity were evaluated by thin layer chromatography (TLC)-bioautography and IC50 spectrophotometrically. Results: The evaluation results show that the butanol fraction leads to a potential value (IC50 99.92 µg/ml). Several compounds, especially flavonoid compounds (including catechin; kaempferol 3-arabinofuranoside 7-rhamnoside; 6,8-Di-C-beta-D-arabino pyranosyl apigenin; 5,7-Dihydroxy-8,4’-dimethoxyisoflavone) were identified by LC-MS/MS by comparing the molecular mass of MS/MS data with literature data. Conclusion: Based on this study, it can be concluded that butanol is the fraction that most actively inhibits tyrosinase, elastase, and collagenase enzymes, which means it potentially becomes a new anti-aging candidate.

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“…Breast cancer rates are known to grow faster in Asia than in the West. It was reported by WHO that nearly 1.38 million cases of breast cancer were diagnosed in 2008 [1] , with a prevalence rate of 23% of all cancer cases in the world. In addition, it is known that 209,000 new cases were found, especially in Southeast Asia [2] .…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies

Fikriansyah,

Nelson,

Latief

et al. 2023

chempublish

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Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.

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Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines

Cited by 7 publications

References 20 publications

POTENTIAL TRACKING OF CYTOTOXIC ACTIVITIES OF MANGROVE PEREPATE (Sonneratia alba) ROOT EXTRACT AS AN ANTICANCER CANDIDATE

POTENTIAL TRACKING OF CYTOTOXIC ACTIVITIES OF MANGROVE PEREPATE (Sonneratia alba) ROOT EXTRACT AS AN ANTICANCER CANDIDATE

Evaluation of the Anti-Tyrosinase-Anti-Aging Potential and Metabolite Profiling From the Bioactive Fraction of Corn Cob (Zea Mays L.)

Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies

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