Cytotoxic activity and structural aspects of iridoids isolated from Veronica thymoides subsp. pseudocinerea

Saraçoğlu, İclal; Harput-Hudaverdi, U. S.; Nagatsu, Akito; Varel, Mehtap

doi:10.1055/s-0028-1084409

Cited by 5 publications

(4 citation statements)

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“…While cytotoxic activity of amphicoside (5) and veronicoside (3) found lower than that of verminoside, 6-O-veratroylcatalposide and verproside were found to have cytostatic activity. Catalpol and aucubin did not show any cytotoxic activity against three of the tested cell lines (Saracoglu et al, 2008;Saracoglu & Harput-Hudaverdi, 2009). Our previous results are in good agreement with present results and could be good explanation of the cytototoxic activity of V. cuneifolia subsp.…”

Section: Discussionmentioning

confidence: 87%

“…cuneifolia showed stronger radical scavenging and cytotoxic activities than V. cymbalaria for all tested concentrations. Cytotoxic activities of aucubin, catalpol, and catalpol derivatives isolated from Veronica species were also determined against Hep-2, RD, and L-20B cell lines, previously (Saracoglu et al, 2008;Saracoglu & Harput-Hudaverdi, 2009). Verminoside (6), the transcaffeic acid ester of catalpol, showed very strong cytotoxicity against tested cell lines.…”

Section: Discussionmentioning

confidence: 99%

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Iridoid content and biological activities ofVeronica cuneifoliasubsp.cuneifoliaandV. cymbalaria

Saraçoğlu

Oztunca

Nagatsu

et al. 2011

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Iridoid content and biological activities ofVeronica cuneifoliasubsp.cuneifoliaandV. cymbalaria

Saraçoğlu

Oztunca

Nagatsu

et al. 2011

Pharmaceutical Biology

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“…Although various Veronica extracts have been used in folk medicine for the treatment of cancer, very few species have been studied for their cytotoxic and anticancer activity [7]. Previous research on various Veronica species has mainly led to the isolation of biologically active compounds such as iridoid glucosides, which have been found to be excellent natural anticancer agents [52][53][54][55][56][57]. Moreover, methanolic and aqueous extracts of several Veronica species have been tested on different cancer cell lines.…”

Section: Antiproliferative Activitymentioning

confidence: 99%

Wild Species Veronica officinalis L. and Veronica saturejoides Vis. ssp. saturejoides—Biological Potential of Free Volatiles

et al. 2021

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Extracts from plants of the genus Veronica have been and continue to be used in traditional medicine to treat various diseases throughout the world. Although often considered a weed, many scientific reports demonstrate that these plants are a source of valuable biologically active compounds and their potential for horticulture should be investigated and considered. In this study, free volatile compounds of essential oils (EO) and hydrosols were extracted from two species: Veronica officinalis, which is most commonly used in traditional medicine, and Veronica saturejoides, an endemic plant that could be obtained by cultivation in horticulture. Volatiles were analyzed by gas chromatography coupled with mass spectrometry (GC, GC-MS). The most abundant compounds identified in the EOs were hexadecanoic acid in V. officinalis EO and caryophyllene oxide in V. saturejoides EO. The hydrosols were characterized by a high abundance of caryophyllene oxide in V. saturejoides hydrosol and of p-vinyl guaiacol for V. officinalis hydrosol. The sites where the volatile compounds are synthesized and stored were analyzed using SEM (Scanning Electron Microscopy); glandular and non-glandular trichomes were detected on stems, leaves and the calyx. Further, to investigate the activity of the free volatile compounds against pathogens, isolated volatile compounds were tested on the antiphytoviral activity against tobacco mosaic virus (TMV) infection. The hydrosols of both investigated species and EO of V. officinalis showed significant antiphytoviral activity. To further investigate the biological potential of these extracts they were also tested for their antiproliferative and antioxidant activities. The results indicate that these compounds are a valuable source of potential anticancerogenic agents that should be investigated in future studies. The presented results are the first report of hydrosol and EO activity against TMV infection, suggesting that these extracts from Veronica species may be useful as natural-based antiphytoviral agents.

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“…For the species V. persica and V. polita , cytotoxic activity was studied for their methanolic and water extracts and they demonstrated potent activity against mouse melanoma cells [ 7 ]. Previous studies of secondary metabolites isolated from many species of the genus Veronica have included free volatile compounds in the form of essential oils and hydrosols [ 8 , 9 , 10 , 11 , 12 , 13 ] and bound volatile compounds such as iridoids, saponins, and phenolic components [ 2 , 4 , 6 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. For the species V. persica , different iridoid glycosides were isolated and identified, such as aucubine, catalposide, amphicoside, veronicoside, and others.…”

Section: Introductionmentioning

confidence: 99%

Identification of Phenolic Compounds Present in Three Speedwell (Veronica L.) Species and Their Antioxidant Potential

Vrca,

Orhanović,

Pezelj

et al. 2024

Antioxidants

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Extracts from Veronica species (speedwells) are known for the various biological activities they show, such as cytotoxic, antimicrobial, anti-inflammatory, and antioxidant activities. Also, the plants from this genus are known as medicinal plants used in traditional medicine worldwide. Phenolic compounds are specialized metabolites that contribute to biological activity the most. Therefore, the aim of this research is identification and quantification of phenolic compounds present in three Veronica species (Veronica anagallis-aquatica L., Veronica persica Poir., and Veronica polita Fr.) using the liquid chromatography-mass spectrometry (LC-MS/MS) technique. All extracts were tested for antioxidant activity with two methods: DPPH (2,2-diphenyl-1-picrylhydrazyl) and ORAC (oxygen radical absorbance capacity). Also, standards for compounds that were detected in the highest amount in all species were also tested for antioxidant activity. Three different solvents (pure methanol, 80% ethanol, and water) were used for the extraction of phenolic components and their comparison in order to test their antioxidant activity as a final goal. The main compounds present in the tested Veronica extracts were: p-hydroxybenzoic acid, vanillic acid, caffeic acid, gentisic acid, and apigenin. V. anagallis-aquatica contained the highest amount of phenolic components in comparison with the two other tested species, V. persica and V. polita. Caffeic acid showed the highest antioxidant activity in both studied methods with an IC50 value for DPPH activity of 1.99 µg/mL. For the plant extracts, in general, methanolic/ethanolic extracts showed higher activity than water extracts in both methods which was expected, as organic solutions extract more phenolic compounds. This research points to the potential application of extracts of different Veronica species for antioxidant activity.

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Cytotoxic activity and structural aspects of iridoids isolated from Veronica thymoides subsp. pseudocinerea

Cited by 5 publications

References 0 publications

Iridoid content and biological activities ofVeronica cuneifoliasubsp.cuneifoliaandV. cymbalaria

Iridoid content and biological activities ofVeronica cuneifoliasubsp.cuneifoliaandV. cymbalaria

Wild Species Veronica officinalis L. and Veronica saturejoides Vis. ssp. saturejoides—Biological Potential of Free Volatiles

Identification of Phenolic Compounds Present in Three Speedwell (Veronica L.) Species and Their Antioxidant Potential

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