Cytotoxic activity evaluation and molecular docking study of phenolic derivatives from Achillea fragrantissima (Forssk.) growing in Egypt

Awad, Basma M.; Habib, Eman S.; Ibrahim, Amany K.; Wanas, Amira S.; Radwan, Mohamed M.; Helal, Mohamed A.; ElSohly, Mahmoud A.; Ahmed, Safwat A.

doi:10.1007/s00044-017-1918-6

Cited by 25 publications

(17 citation statements)

References 23 publications

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“…Piceol, veratric acid, eupatilin 7-methyl ether, chrysosplenol D, cirsiliol, and cirsimaritin isolated from A. fragrantissima methanol extract displayed a promising cytotoxic activity against MCF7 (IC 50 = of 18.2, 15.7, 9.5, 8.33, 3.23, and 3.83 µg/ ml, respectively), and against HepG2 with IC 50 values of 19.4, 41.2, 28.3, 20.8, 23.8, and 23.8 µg/ml, respectively. In addition, they demonstrated a cytotoxic activity against A549 cell lines (IC 50 = 17.8, 13.6, 3.98, and 10.3 µg/ml respectively) (200). Phytochemical investigation of A. cretica resulted in the isolation of two new sesquiterpene lactones, achicretin 1 and achicretin 2.…”

Section: Anticancer Activitiesmentioning

confidence: 99%

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Salehi

Selamoğlu

Sevindik

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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The genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary metabolites, including terpenes, polyphenols, flavonoids and others. Multiple studies have assessed the biological effects and other aspects of Achillea spp. In a number of preclinical studies, Achillea plants and their essential oils have demonstrated promising antibacterial properties against a number of human and plant pathogens. Besides, the plants have displayed strong antioxidative and potent anti-proliferative and anticancer properties in various cellular and animal models. Achillea plants have widely been used as food preservative in food industry. Clinical studies have indicated its potential against multiple sclerosis (MS), irritable bowel syndrome (IBS), ulcerative colitis, episiotomy wound, primary dysmenorrhea, oral mucositis etc. The present work focuses to provide a brief overview on folk knowledge, phytochemistry, biological activity and applications of Achillea plants. There is a close relationship between the traditional ethnobotanical usage and pharmacological and clinical data from different Achillea spp. The application of Achillea plants and their extracts seems to be a promising alternative for antimicrobial and antioxidant purposes in food, pharmaceutical and cosmetic industries.

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Section: Anticancer Activitiesmentioning

confidence: 99%

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Salehi

Selamoğlu

Sevindik

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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“…The 1 H NMR spectra of F5 and F6 revealed that teuflavoside was the main secondary metabolite of these fractions and, as consequence, they were not purified. The structures of the isolated compounds were deduced from the 1 D and 2 D NMR spectra and confirmed by comparison of 1 H-and 13 C NMR data with those reported in the literature 27,[38][39][40] .…”

Section: Isolation and Characterisationmentioning

confidence: 59%

Flavonoids and Acid-Hydrolysis derivatives ofNeo-Clerodane diterpenes fromTeucrium flavumsubsp.glaucumas inhibitors of the HIV-1 reverse transcriptase–associated RNase H function

Fois

Corona

Tramontano

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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Bioassay-guided fractionation of the ethyl acetate extract from Teucrium flavum subsp. glaucum, endowed with inhibitory activity towards the HIV-1 reverse transcriptase-associated RNase H function, led to the isolation of salvigenin (1), cirsimaritin (2) and cirsiliol (3) along with the neo-clerodanes teuflavin (4) and teuflavoside (5). Acid hydrolysis of the inactive teuflavoside provided three undescribed neo-clerodanes, flavuglaucins A-C (7-9) and one known neo-clerodane (10). Among all neo-clerodanes, flavuglaucin B showed the highest inhibitory activity towards RNase H function with a IC 50 value of 9.1 lM. Molecular modelling and site-directed mutagenesis analysis suggested that flavuglaucin B binds into an allosteric pocket close to RNase H catalytic site. This is the first report of clerodane diterpenoids endowed with anti-reverse transcriptase activity. Neo-clerodanes represent a valid scaffold for the development of a new class of HIV-1 RNase H inhibitors.

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“…Apigenin derivatives were reported in the form of 8-C glucoside (vitexin) (10) by Taskin et al [45] from A. nobilis and from A. magnifica [37], respectively. Isovitexin (11), a 6-C-glucoside, was identified from A. alpina, A. fragrantissima, A. millefolium and A. wilhelmsii [18,20,30,50]. In addition, its 4 -methyl ether (23) was reported only in A. fragrantissima [30].…”

Section: Flavonoidsmentioning

confidence: 99%

“…Isovitexin (11), a 6-C-glucoside, was identified from A. alpina, A. fragrantissima, A. millefolium and A. wilhelmsii [18,20,30,50]. In addition, its 4 -methyl ether (23) was reported only in A. fragrantissima [30]. Moreover, a 7-methyl ether derivative, namely swertisin (13), was reported from A. wilhelmsii [50].…”

Section: Flavonoidsmentioning

confidence: 99%

Phytochemistry and Evidence-Based Traditional Uses of the Genus Achillea L.: An Update (2011–2021)

et al. 2021

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Knowledge within the field of phytochemistry research has accelerated at a tremendous speed. The excess of literature reports featuring plants of high ethnopharmacological importance, in combination with our interest in the Asteraceae family and traditional medicine, led us to acknowledge the value of the Achillea L. genus. In a broad context, the various Achillea species are used around the globe for the prevention and treatment of different diseases, including gastrointestinal problems, haemorrhages, pneumonia, rheumatic pains, diuresis, inflammation, infections, and wounds, as well as menstrual and gynaecologic abnormalities. The present review aims to provide and summarize the recent literature (2011–2021) on the phytochemistry of the Achillea genus. In parallel, this study attempts to bridge the reports on the traditional uses with modern pharmacological data. Research articles that focused on secondary metabolites, traditional uses and pharmacological activities were collected from various scientific databases such as Pubmed, ScienceDirect, Reaxys and Google Scholar. This study revealed the presence of 141 phytochemicals, while 24 traditionally used Achillea spp. were discussed in comparison to current data with an experimental basis.

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Cytotoxic activity evaluation and molecular docking study of phenolic derivatives from Achillea fragrantissima (Forssk.) growing in Egypt

Cited by 25 publications

References 23 publications

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Flavonoids and Acid-Hydrolysis derivatives ofNeo-Clerodane diterpenes fromTeucrium flavumsubsp.glaucumas inhibitors of the HIV-1 reverse transcriptase–associated RNase H function

Phytochemistry and Evidence-Based Traditional Uses of the Genus Achillea L.: An Update (2011–2021)

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