Cytotoxic activity of Acalypha indica L. hexane extract on breast cancer cell lines (MCF-7)

Abstract

Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues. Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Research advances over the past two decades have changed the landscape of breast cancer care. Genetic testing, targeted treatments and more precise surgical techniques have helped boost survival rates in some cases while helping to support breast cancer patients’ quality of life. The herb Acalypha indica which belongs to Euphorbiaceae family has multiple medicinal properties which include anti-fungal, anti-bacterial, anti-oxidant, anti-inflammatory, anti-helmintic, anti-ulcer, anti-venom, anticancerous, and neuro-protective activity. The present study emphasises cytotoxic activity of hexane leaf crude extract of Acalypha indica Linn. On mcf-7cell lines by MTT (3-(4, 5-Dimethylthiazol-2)-2,5- Diphenyltetrazolium Bromide) assay method using Cisplatin as a positive control. Hexane Crude extract of different concentrations (10µg/ml, 25µg/ml, 50µg/ml and 100µg/ml) were treated with cell lines, Out of these concentrations 50µg/ml showed maximum inhibitory effect (IC50 value). Hence the present study is taken up to systematically evaluate the anti-cancer properties of the extracts and also to isolate and characterize the active principles of Acalypha indica.

Cytotoxic Effect In Vitro of Acalypha monostachya Extracts over Human Tumor Cell Lines

“…It has been previously reported that MTT does not cause injury or induce cell death [33]. The results of our study correlate with previous studies describing that the crude HE of A. indica has an IC50 of 50 µg/mL, and cytotoxic effects were observed from the concentration of 10 µg/mL to 100 µg/mL, where a slight increase in viability was observed [34].…”